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| Status |
Public on Nov 01, 2009 |
| Title |
Gene expression profiling in differential cognitive outcomes in aging: Dentate Gyrus |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Functional alterations in medial temporal lobe structures, particularly the hippocampus, are central to age-related deficits in episodic memory. Research in aging laboratory animals has characterized physiological and cellular alterations in the hippocampus that occur in association with the presence and severity of such cognitive impairment. The current study compares alterations across hippocampal subregions by gene expression profiling in a rat model that closely mirrors individual differences in neurocognitive features of aging humans across a spectrum of outcomes, including both impaired memory and preserved function. Using mRNA profiling of the CA1, CA3 and dentate gyrus subregions, we have distinguished between gene groups and pathways related to chronological age and those specifically associated with impaired or preserved cognitive ability in aged rats. We confirmed earlier reported changes in gene groups related to inflammation and oxidative stress in multiple subregions and found these to be more associated with chronological age than cognitive function per se. The CA3 profile was best able to segregate aged impaired, aged unimpaired and young subject groups from each other. Characterization of gene changes that distinguished preserved from impaired function among the aged animals found altered expression of synaptic plasticity and neurodegenerative disease-related genes. Together these gene changes suggest recruitment of adaptive mechanisms that mediate synaptic plasticity to maintain function and structural integrity in aged unimpaired rats that does not occur in aged impaired animals.
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| Overall design |
RNA samples from DG region of the hippocampi of young animals, aged animals with unimpaired spatial learning, and aged animals with impaired spatial learning were compared to one another using Affymetrix GeneChip Rat Genome 230 2.0 arrays.
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| Contributor(s) |
Haberman RP, Colantuoni C, Lunt A, Pedersen JT, Gallagher M |
| Citation(s) |
19913943 |
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| Submission date |
Feb 05, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Carlo Colantuoni |
| E-mail(s) |
[email protected]
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| Phone |
4104931439
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| Organization name |
Johns Hopkins Univ. School of Medicine
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| Department |
Neurology
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| Street address |
733 N Broadway
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (24)
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| GSM367878 |
Aged Impaired DG, biological rep4 |
| GSM367879 |
Aged Impaired DG, biological rep5 |
| GSM367880 |
Aged Impaired DG, biological rep6 |
| GSM367881 |
Aged Impaired DG, biological rep7 |
| GSM367882 |
Aged Impaired DG, biological rep8 |
| GSM367883 |
Aged Unimpaired DG, biological rep1 |
| GSM367884 |
Aged Unimpaired DG, biological rep2 |
| GSM367885 |
Aged Unimpaired DG, biological rep3 |
| GSM367886 |
Aged Unimpaired DG, biological rep4 |
| GSM367887 |
Young DG, biological rep9 |
| GSM367888 |
Aged Unimpaired DG, biological rep6 |
| GSM367889 |
Aged Unimpaired DG, biological rep7 |
| GSM367890 |
Aged Unimpaired DG, biological rep8 |
| GSM367891 |
Young DG, biological rep1 |
| GSM367892 |
Young DG, biological rep2 |
| GSM367893 |
Young DG, biological rep3 |
| GSM367894 |
Young DG, biological rep4 |
| GSM367895 |
Young DG, biological rep5 |
| GSM367896 |
Young DG, biological rep6 |
| GSM367897 |
Young DG, biological rep7 |
| GSM367898 |
Young DG, biological rep8 |
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| This SubSeries is part of SuperSeries: |
| GSE14726 |
Gene expression profiling in hippocampal subregions in differential cognitive outcomes in aging |
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| Relations |
| BioProject |
PRJNA114345 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE14725_RAW.tar |
65.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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