GEO DataSets

(Submitter supplied) Antigenic variation in Plasmodium falciparum is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of chromatin. Histone-modifying ‘sirtuin’ enzymes PfSir2a and PfSir2b have been implicated in this process. We examined the effect of genetic disruption of sirtuins on var gene expression. Comparative Genomic Hybridization profile indicate that loss of PfSir2a in 3D7 resulted in strikingly rearranged chromosomes.

Organism:

Plasmodium falciparum NF54; Plasmodium falciparum; Plasmodium falciparum 3D7

Type:

Genome variation profiling by genome tiling array

Platform:

GPL19254

2 Samples

Download data: PAIR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL27859 GPL27825

6 Samples

Download data: TXT

(Submitter supplied) We performed Agilent chip analysis with synchronized 0-6h ring stage parasites of three P.falciparum lines within their third life cycle, to study the change of expression profiling when knocking down PfSWIB .

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL27859

3 Samples

Download data: TXT

(Submitter supplied) We performed RNA-Seq analysis with synchronized 0-6h ring stage parasites of three P.falciparum lines within their third life cycle, to study the change of expression profiling when knocking down PfSWIB. The comparison analysis on screening of differentially expressed genes was done in parasite lines including 3D7(wild type: blank control), PfSWIB (wild type: self-control) and PfSWIB∆ (PfSWIB knockdown). more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27825

3 Samples

Download data: TXT

(Submitter supplied) This experiment studies the effect of knocking out the transcriptional regulator SIR2 in 3D7 parasites. RNA was harvested from ring-stage parasites at 8 hours post-infection. Keywords = SIR2 Keywords = epigenetic regulation Keywords = antigenic variation Keywords = var Keywords = Plasmodium falciparum Keywords: other

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Dataset:

GDS1350

Platform:

GPL1892

4 Samples

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Expression profiling of 3D7 silent information regulator 2 homolog (Sir2) knockout at ring stage, 8 hours post-invasion. Results identify Sir2-mediated, reversible heterochromatin silencing as one tier of epigenetic regulation of the antigenic variation var gene family.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1892

Series:

GSE2369

4 Samples

Download data

(Submitter supplied) P. falciparum H4K8ac ChIP-seq

Organism:

Plasmodium falciparum

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19269 GPL16607

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL11250 GPL11248

135 Samples

Download data: GPR

(Submitter supplied) Study of chromatin changes of P. falciparum in response to changes in the levels of histone H4 acetylations especially H4K8ac using chromatin immunoprecipitation coupled to microarray chip (ChIP-on-chip)

Organism:

Plasmodium falciparum

Type:

Genome variation profiling by array

Platform:

GPL11250

39 Samples

Download data: GPR, TXT

(Submitter supplied) Transcriptional analaysis of P. falciparum in response to changes in the levels of histone H4 acetylations especially H4K8ac

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL11248

96 Samples

Download data: GPR, TXT

(Submitter supplied) P. falciparum undergoes antigenic variation during its life cycle in the human host. To accomplish this, the malaria parasite has developed mechanisms that ensure the expression of a single member of the var gene family to produce one of the PfEMP1 variant proteins. Here we carry out RNA-seq and ChIP-seq analyses of histone modifications to explore transcriptional and epigenomic changes taking place between the transmissible stages of the parasite i.e. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16607

21 Samples

Download data: TXT, WIG