|
| Status |
Public on Oct 02, 2014 |
| Title |
Comparative Genomic Hybridizaions of 3D7∆PfSir2a and NF54 compared to reference strain 3D7 |
| Platform organism |
Plasmodium falciparum 3D7 |
| Sample organisms |
Plasmodium falciparum; Plasmodium falciparum NF54; Plasmodium falciparum 3D7 |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Antigenic variation in Plasmodium falciparum is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of chromatin. Histone-modifying ‘sirtuin’ enzymes PfSir2a and PfSir2b have been implicated in this process. We examined the effect of genetic disruption of sirtuins on var gene expression.
Comparative Genomic Hybridization profile indicate that loss of PfSir2a in 3D7 resulted in strikingly rearranged chromosomes.
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| |
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| Overall design |
3D7 common reference; Samples: PfSir2a and NF54
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| |
|
| Contributor(s) |
Ferdig MT |
| Citation(s) |
25780929 |
| |
| Submission date |
Oct 01, 2014 |
| Last update date |
Jan 16, 2020 |
| Contact name |
Michael Ferdig |
| E-mail(s) |
[email protected]
|
| Phone |
(574)631-9973
|
| Organization name |
University of Notre Dame
|
| Department |
Biological Sciences
|
| Lab |
Ferdig Lab
|
| Street address |
280 Galvin Life Science
|
| City |
Notre Dame |
| State/province |
IN |
| ZIP/Postal code |
46556 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19254 |
NimbleGen Pfalciparum 385k array v1.0 [2005-05-10_Plasmodium_3D7_WG_CGH] |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA262722 |
