Similar studies for GEO DataSets (Select 200070667) - GEO DataSets

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Items: 20

Select item 2000706671.

Mechano-sensitive Gene Expression with RNA-Seq: Revisiting the Osteocytic Cell Response to Fluid Flow

(Submitter supplied) Bone adaptation to mechanical loading is regulated via signal transduction by mechano-sensing osteocytes. Mineral-embedded osteocytes experience strain-induced interstitial fluid flow and fluid shear stress, and broad shifts in gene expression are key components in the signaling pathways that regulate bone turnover. RNA sequencing analysis, or RNA-Seq, enables more complete characterization of mechano-sensitive transcriptome regulation than previously possible. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE70667

ID:: 200070667

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Select item 2000428742.

Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways

(Submitter supplied) Osteocytes, positioned within bone’s interstitial space, are subject to fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone metabolism. The objective of this study was to utilize high-throughput approaches to examine the time course of flow-induced changes in osteocyte gene transcript and protein levels. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
24 Samples

Download data: CEL

Series

Accession:: GSE42874

ID:: 200042874

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Select item 2000022343.

Osteoblast and Osteocyte Profiles at Different Cell-cummunication Status

(Submitter supplied) Type of Experiment: 1) Profiles of Osteoblast vs. osteocyte in vitro; 2) Profiles of osteoblast low density vs. confluency in vitro; 3) Profiles of osteocyte with gap junction vs. without gap junction. Experimental factors: 1) 2T3 osteoblast cells at low density expressed extensive filopodia, reminiscent of early osteoblast precursors and similar to MLO-Y4 dendritic processes. 2) MLO-Y4 osteocytes at low vs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL151
12 Samples

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Series

Accession:: GSE2234

ID:: 200002234

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Select item 2000629814.

The Parathyroid Hormone-Regulated Transcriptome in Osteocytes: Parallel Actions with 1,25-Dihydroxyvitamin D3 to Oppose Gene Expression Changes During Differentiation and to Promote Mature Cell Function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
7 Samples

Download data: BED, BEDGRAPH, TXT

Series

Accession:: GSE62981

ID:: 200062981

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Select item 2000629795.

(Submitter supplied) Although localized to the mineralized matrix of bone, osteocytes are able to respond to systemic factors such as the calciotropic hormones 1,25(OH)2D3 and PTH. In the present studies, we examine the transcriptomic response to PTH in an osteocyte cell model and found that this hormone regulated an extensive panel of genes. Surprisingly, PTH uniquely modulated two cohorts of genes, one that was expressed and associated with the osteoblast to osteocyte transition and the other a cohort that was expressed only in the mature osteocyte. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: TXT

Series

Accession:: GSE62979

ID:: 200062979

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Select item 2000629786.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE62978

ID:: 200062978

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Select item 2000621287.

Whole gene expression data from osteocyte-like cell line MLO-Y4 under large gradient high magnetic field (LG-HMF)

(Submitter supplied) osteocyte is the mechanosensor in bone, taking up pivotal position in mediating the mechano-induced bone remodeling. Dimagnetic levitation has been used to stimulating a reduced gravity environment for studing the effects of changed gravity to different organisms.we constructed a superconducting magnet based platform with a large gradient high magnetic field(LG-HMF),which can provide three apparent gravity levels (μ-g,1-g and 2-g). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE62128

ID:: 200062128

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Select item 2000458928.

Temporal Concordance between Apical and Transcriptional Points-of-Departure for Chemical Risk Assessment

(Submitter supplied) The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development are overwhelming the capacity of the traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate chemical risks. In this study, rats were dosed orally with multiple doses of six chemicals for 5 days, 2, 4, and 13 weeks. Target organs were analyzed for traditional histological and organ weight changes and transcriptional changes using microarrays. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL16985
720 Samples

Download data: CEL

Series

Accession:: GSE45892

ID:: 200045892

Select item 2000810979.

RNA-seq Based Transcriptomic Map Reveals New Insights Into Mouse Salivary Gland Development and Maturation

(Submitter supplied) Analysis of gene expression changes during mouse salivary gland development using RNA-Seq

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
13 Samples

Download data: CSV

Series

Accession:: GSE81097

ID:: 200081097

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Select item 20006583210.

RNA-Seq atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications

(Submitter supplied) Purpose: provide evidence that RNA-seq can add information to transcriptome profiling already discovered by other technologies for atopic dermatitis Methods: mRNA profiles of 20 atopic dermatitis were analyzed to compare lesional and non-lesional skin, then transcriptomes found by reads were compared to Microarray and RT-PCR Results:RNA-seq provided complementary genes to AD transcriptome IL-36 and TREM-1 Conclusions: Our study represents the first analysis of lesional AD tissue by RNA-seq and comparison to microarray and RT-PCR

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10999
40 Samples

Download data: TXT

Series

Accession:: GSE65832

ID:: 200065832

Select item 20003624411.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL9052 GPL13695
16 Samples

Download data: CEL, TXT

Series

Accession:: GSE36244

ID:: 200036244

Select item 20003624312.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix)

(Submitter supplied) Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing technologies have been developed that hold the promise of measuring the transcriptome with RNA-seq in a more accurate and unbiased manner than microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13695
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE36243

ID:: 200036243

Select item 20003624213.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: TXT

Series

Accession:: GSE36242

ID:: 200036242

Select item 20008133614.

Next generation sequencing analysis of soy glyceollins and 17-β estradiol: Effects on transcript abundance in the female mouse brain

(Submitter supplied) Purpose: The goal of this study was to compare and contrast the next generation sequencing data to data obtained from a whole brain microarray study

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Download data: TXT

Series

Accession:: GSE81336

ID:: 200081336

PubMed Similar studies SRA Run Selector

Select item 20006630315.

Transcriptional responses to i.v. administered I-131 in various mouse normal tissues underlie diurnal variation

(Submitter supplied) Circadian rhythm study on transcriptional responses to i.v. administered 90 kBq iodine-131 after 24h in mouse kidney cortex and medulla, liver, lungs, spleen, and thyroid. Female BALB/c nude mice (n=4/group) were i.v. injected with 90 kBq 131I at three different times of day, i.e. at 9.00 am, at 12.00 pm, or at 3.00 pm, and killed under anesthesia after 24h following treatment for excision of organs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
136 Samples

Download data: TXT

Series

Accession:: GSE66303

ID:: 200066303

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Select item 20004989316.

RNA-Seq and expression microarray highlight different aspects of the fetal amniotic fluid transcriptome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL570 GPL11154
10 Samples

Download data: CEL, FPKM_TRACKING

Series

Accession:: GSE49893

ID:: 200049893

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Select item 20004989117.

RNA-Seq and expression microarray highlight different aspects of the fetal amniotic fluid transcriptome [microarray]

(Submitter supplied) The second trimester fetal transcriptome can be assessed based on cell-free RNA found within the amniotic fluid supernatant. The objective of this study was to compare the suitability of two technologies for profiling the human fetal transcriptome: RNA-Seq and expression microarray. Comparisons were based on total numbers of gene detected, rank-order gene expression, and functional genomic analysis. more...