Similar studies for GEO DataSets (Select 200070831) - GEO DataSets

Select item 2000708311.

MiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA

(Submitter supplied) We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: TXT

Series

Accession:: GSE70831

ID:: 200070831

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000704342.

Gene expression data from HEK-293T cells transfected with miR-194 mimics

(Submitter supplied) Nuclear factor κB (NF-κB) pathway plays an important role in hepatocellular carcinoma (HCC) progression. miR-194 was previously shown to reduce the induction of NF-κB activity upon addition of tumor necrosis factor α (TNFα). To clarify the molecular mechanism responsible for the effect of miR-194 on NF-κB pathway, mRNA microarray assays were performed to identify the genes that were suppressed by miR-194.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL

Series

Accession:: GSE70434

ID:: 200070434

Select item 2000440893.

MicroRNA expression changes associated with specific STAT3 activation

(Submitter supplied) Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor in cancer. However, while the protein-coding target genes of STAT3 have been extensively studied, the microRNA target genes of STAT3 are less understood. MicroRNAs are short, non-coding RNAs that regulate messenger RNAs through translational inhibition and transcript degradation. They have been found to be involved in all aspects of cancer biology. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL11316 GPL14851
12 Samples

Download data: TXT

Series

Accession:: GSE44089

ID:: 200044089

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000411004.

Genome-wide TNFα-induced p65 binding before and after telomerase inhibition in HeLa cells

(Submitter supplied) Chromatin immunoprecipitation sequencing (ChIP-seq) was performed to analyze the effect of telomerase inhibition on TNFα-induced genome-wide p65 binding in HeLa cells. By obtaining over 40 million uniquely mappable reads per sample from ChIP-seq, maps for TNFα-induced p65 binding in absence and presence of an hTERT inhibitor, MST-312, were generated. As expected, TNFα treatment significantly increased genome-wide p65 occupancy. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13393
4 Samples

Download data: BED

Series

Accession:: GSE41100

ID:: 200041100

PubMed Similar studies SRA Run Selector

Select item 2000423355.

Expression data for MALT1-responsive genes

(Submitter supplied) In lymphocyte lineages, mucosa-associated lymphoid tissue 1 (MALT1) mediates the nuclear factor-κB activation signal that stimulates progression of malignant tumors. However, its expression is inactivated in oral carcinoma patients with worse prognosis. Unveiling genes under the control of MALT1 will provide valuable information for understanding of the mechanism of carcinoma progression. We profiled gene datasets altered in response to MALT1 in oral carcinoma cells by the microarray analysis. more...