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Items: 14

1.

General response of Salmonella enterica serovar Typhimurium to desiccation: A new role for the virulence factors sopD and sseD in survival.

(Submitter supplied) Salmonella can survive for long periods under extreme desiccation conditions. This stress response poses a risk for food safety, but relatively little is known about the molecular and cellular regulation of this adaptation mechanism. To determine the genetic components involved in Salmonella’s cellular response to desiccation, we performed a global transcriptomic analysis comparing Salmonella Typhimurium cells equilibrated to low water activity (aw 0.11) and cells equilibrated to high water activity (aw 1.0). more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. ATCC 14028
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20792
2 Samples
Download data: TXT
Series
Accession:
GSE86580
ID:
200086580
2.

FNR- vs WT in anoxic conditions

(Submitter supplied) Salmonella enterica var. Typhimurium (S. Typhimurium) is a Gram-negative, facultative intracellular pathogen that infects the intestinal tracts of humans and animals. In the host, S. Typhimurium encounters a wide range of oxygen concentrations going from oxic conditions in the stomach to near anoxic conditions in the distal sigmoid colon-rectal junction. In Escherichia coli, FNR (Fumarate Nitrate Reductase) is one of the main regulatory proteins involved in oxygen sensing and in controlling the transcription of the genes required for the aerobic/anaerobic transition.. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium; Salmonella
Type:
Expression profiling by array
Platform:
GPL1835
6 Samples
Download data
Series
Accession:
GSE3657
ID:
200003657
3.

Transcriptomic profiling of Salmonella Typhimurium upon desiccation on stainless steel and subsequent rehydration

(Submitter supplied) Transcriptional profiles of Salmonella Typhimurium str. ST4/74 air-dried onto stainless steel for 4 h was compared to an early stationary phase (ESP) culture control. Cells that had been air-dried for 4 h were then subsequently rehydrated with water for a 30 min period, after which the transcriptional profile was compared to an ESP control.
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74
Type:
Expression profiling by array
Platform:
GPL17132
6 Samples
Download data: TXT
Series
Accession:
GSE46763
ID:
200046763
4.

Influence of Microbial and Host Cell Sublethal Heat Stress on S. Typhimurium Gene Expression

(Submitter supplied) Environmental stress contributes to the outcome of infection by impacting both microbial virulence and host susceptibility to infection. Thermal processing, commonly used for decontamination of poultry in the food industry, may elicit sublethal stress on resistant serovars of Salmonella. We employed traditional heat shock temperatures (42 and 48ºC), similar to avian body temperature and poultry processing conditions, to study gene expression of Salmonella enterica serovar Typhimurium. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium; Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Type:
Expression profiling by array
Platform:
GPL9181
12 Samples
Download data: GPR
Series
Accession:
GSE18089
ID:
200018089
5.

Detection of Transposon Mutants That Cannot Survive in Macrophages and Mice.

(Submitter supplied) An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. We have adapted a microarray-based transposon tracking strategy for use with a Salmonella enterica serovar Typhimurium cDNA microarray in order to identify genes important for survival and replication in RAW 264.7 mouse macrophage-like cells or in the spleens of BALB/cJ mice. A 50,000-CFU transposon library of S. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by array
Platform:
GPL2772
12 Samples
Download data
Series
Accession:
GSE3179
ID:
200003179
6.

Comparative Transcriptomic Analysis of Salmonella in Desiccation

(Submitter supplied) To explore the mechanisms of Salmonella desiccation resistance, we studied the transcriptomic responses in Salmonella Tennessee (Tennessee), using S. Typhimurium LT2 (LT2), a strain weakly resistant to desiccation, as a reference strain. In response to 2 h air-drying at 11% equilibrated relative humidity, approximately one-fourth of the ORFs in the Tennessee genome and one-fifth in LT2 were differentially expressed (> 2-fold). more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2; Salmonella enterica subsp. enterica serovar Tennessee
Type:
Expression profiling by array
Platform:
GPL15942
12 Samples
Download data: TXT
Series
Accession:
GSE40146
ID:
200040146
7.

The nucleoid-associated protein HU controls three regulons that coordinate virulence and general physiology in Salmonella enterica serovar Typhimurium

(Submitter supplied) The regulon of genes controlled by the HU nucleoid-associated proteins was examined in Salmonella enterica serovar Typhimurium (S. Typhimurium). DNA microarrays were used to detect the effect on the bacterial transcriptome of knockout mutations in the hupA, the hupB and in both the hupA and hupB genes. Distinct but overlapping patterns of gene expression were detected in the transcriptome at each time point for each of the three mutants, pointing to the existence of not one but three regulons of genes controlled by the HU proteins. more...
Organism:
Salmonella enterica; Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by array
Platform:
GPL9091
37 Samples
Download data: GPR
Series
Accession:
GSE22860
ID:
200022860
8.

Genome-wide screen for salmonella genes required for long-term systemic infection of the mouse.

(Submitter supplied) This datasets includes all arrays from the first passage through 129SvJ mice (28 days) and the second independent passage (29 days). The first passage arrays are the same as included in the experiment set "129SvJ Pass 1 28 dpi arrays" and the second passage arrays are the same as included in the experiment set "129SvJ Pass 2 28 dpi arrays". Input arrays are also included and collectively they represent two biological replicates for negative selection at ~4 weeks post infection. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by array
Platform:
GPL3545
29 Samples
Download data
Series
Accession:
GSE4461
ID:
200004461
9.

Transcriptome of dehydrated vs hydrated Salmonella cells

(Submitter supplied) Transcriptional profiles of dehydrated Salmonella Typhimurium SL1344 cells post 22h air drying were compared to those of SL1344 cells incubated for 22 h in DDW
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Salmonella enterica
Type:
Expression profiling by array
Platform:
GPL11279
4 Samples
Download data
Series
Accession:
GSE38475
ID:
200038475
10.

Gene expression analysis of S. Typhimurium cells residing in the food vacuole (phagosome) of the bacteria grazing ciliate Tetrahymena

(Submitter supplied) The gene expression of Salmonella enterica Typhimurium MB282 residing in the food vacuole (phagosome) of Tetrahymena was analyzed by microarray.
Organism:
Salmonella enterica
Type:
Expression profiling by array
Platform:
GPL10271
27 Samples
Download data: GPR
Series
Accession:
GSE21308
ID:
200021308
11.

First insights into the pleiotropic role of vrf (yedF), a newly characterized gene of Salmonella Typhimurium

(Submitter supplied) Salmonella possesses virulence determinants that allow replication under extreme conditions and invasion of host cells, causing disease. Here, we examined four putative genes, predicted to encode membrane proteins (ydiY, ybdJ, STM1441 and ynaJ) and a putative transcriptional factor (yedF). These genes were identified in a previous, study of a S. Typhimurium clinical isolate and its multidrug-resistant counterpart. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23683
6 Samples
Download data: TXT
Series
Accession:
GSE101075
ID:
200101075
12.

Stress response of Salmonella Typhimurium to acidified nitrite

(Submitter supplied) The antimicrobial action of the curing agent NaNO2, which is added as a preservative to raw meat products, depends on its conversion to nitric oxide and other reactive nitrogen species under acidic conditions. In this study, we applied RNA-sequencing to analyze the acidified NaNO2 shock and adaptive response of Salmonella Typhimurium, a frequent contaminant in raw meat. Upon a 10 minute exposure to 150 mg/l NaNO2 in LB pH 5.5 acidified with lactic acid, genes involved in nitrosative stress protection together with several other stress related genes were induced. more...
Organism:
Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18633
4 Samples
Download data: TXT
Series
Accession:
GSE57238
ID:
200057238
13.

A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos

(Submitter supplied) The changes in the transcriptome of Fundulus heteroclitus embryos incubated in water or in air from the blastula stage was investigated.
Organism:
Fundulus heteroclitus
Type:
Expression profiling by array
Platform:
GPL9786
42 Samples
Download data: TXT
Series
Accession:
GSE19424
ID:
200019424
14.

Desiccation induces varied responses within a soil bacterial genus

(Submitter supplied) Nine Curtobacterium strains (three from three clades) were subjected to a lab desiccation experiment with no access to moisture or nutrients to compare between clades. RNA was extracted at days 0, 1, and 32 and sequenced
Organism:
Curtobacterium
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33356
81 Samples
Download data: CSV, SF
Series
Accession:
GSE230266
ID:
200230266

Supplemental Content

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