Similar studies for GEO DataSets (Select 200089878) - GEO DataSets

Select item 2000898781.

Gene expression data from induced Pluripotent Stem cells from Parkinson's Disease patients harbouring amplification of, or mutations in the SNCA gene, and from healthy control donors [genotype]

(Submitter supplied) We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation and downstream assays. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platforms:: GPL13829 GPL21168 GPL22678
19 Samples

Download data: TXT

Series

Accession:: GSE89878

ID:: 200089878

PubMed Full text in PMC Similar studies

Select item 2000898862.

Gene expression data from induced Pluripotent Stem cells from Parkinson's Disease patients harbouring amplification of, or mutations in the SNCA gene, and from healthy control donors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

4 related Platforms
32 Samples

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Series

Accession:: GSE89886

ID:: 200089886

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000898833.

Gene expression data from induced Pluripotent Stem cells from Parkinson's Disease patients harbouring amplification of, or mutations in the SNCA gene, and from healthy control donors [gene expression]

(Submitter supplied) We have generated human induced Pluripotent Stem cells (hiPSc) using Sendai virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation and downstream assays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
13 Samples

Download data: TXT

Series

Accession:: GSE89883

ID:: 200089883

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000307924.

Expression data from Parkinson's iPSCs with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative

(Submitter supplied) A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplication of SNCA encoding α-synuclein. α-Synuclein dysfunction is common to all forms of PD, and SNCA triplication leads to fully penetrant familial PD with accelerated pathogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4156
Platform:: GPL570
5 Samples

Download data: CEL

Series

Accession:: GSE30792

ID:: 200030792

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000283675.

Expression and SNP data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL5175 GPL8882
26 Samples

Download data: CEL

Series

Accession:: GSE28367

ID:: 200028367

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000283666.

SNP data from genomic DNA from a subject, fibroblasts, iPSCs and neurons with four copies of SNCA, and genomic DNA from an unaffected first degree relative and equivalent cell lines

(Submitter supplied) A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplication of SNCA encoding α-synuclein. α-Synuclein dysfunction is common to all forms of PD, and SNCA triplication leads to fully penetrant familial PD with accelerated pathogenesis. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL8882
11 Samples

Download data: TXT

Series

Accession:: GSE28366

ID:: 200028366

PubMed Full text in PMC Similar studies

Select item 2000283657.

Expression data from fibroblasts, iPSCs and neurons with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative

(Submitter supplied) A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplication of SNCA encoding α-synuclein. α-Synuclein dysfunction is common to all forms of PD, and SNCA triplication leads to fully penetrant familial PD with accelerated pathogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
15 Samples

Download data: CEL

Series

Accession:: GSE28365

ID:: 200028365

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 41568.

Parkinson's disease induced pluripotent stem cell model with triplication of the α-synuclein locus

Analysis of iPSC lines derived from a PD patient with SNCA triplication and an unaffected first-degree relative. Triplication of SNCA, encoding α-synuclein, causes an aggressive form of PD. Results provide insight into the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 cell line, 2 cell type, 3 genotype/variation sets

Platform:: GPL570
Series:: GSE30792
5 Samples

Download data: CEL

DataSet

Accession:: GDS4156

ID:: 4156

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001576359.

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

(Submitter supplied) TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. In AD mouse models, knockout (KO) of TREM2 impairs microglial clustering around amyloid, and prevents microglial activation. The R47H mutation is proposed to reduce TREM2 ligand binding. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
9 Samples

Download data: TXT

Series

Accession:: GSE157635

ID:: 200157635

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20007815210.

Derivation, characterization, and neuronal differentiation of integration-free induced pluripotent stem cell lines from Parkinsons disease patients carrying SNCA, LRRK2, PARK2, and GBA mutations

(Submitter supplied) Analysis of whole genome expression in control and patients with Parkinsons disease iPSC lines. The hypothesis tested in present study was that deficient GBA, SNCA, LRRK2 and PARKIN expression can be used for disease modeling by their affects on multiple pathways. These results provide information on relationship between PD genes and mitochondria related gene expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE78152

ID:: 200078152

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019934911.

Time series mRNA abundance measurement triggered by ActinomycinD treatment in patient iPSC derived neurons

(Submitter supplied) We measured bulk mRNA abundance in Ngn2 induced patient derived cortical neurons in synucleinophaty models. ActD shuts off the transcription allowing us to measure mRNA decay.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
60 Samples

Download data: TXT

Series

Accession:: GSE199349

ID:: 200199349

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008468412.

Dysregulated synaptic gene expression and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease

(Submitter supplied) We generated de novo induced pluripotent stem cells (iPSCs) from two Parkinson’s Disease patients (PD) harboring the p.A53T mutation. iPSC-derived mutant neurons displayed disease-relevant phenotypes at basal conditions, including protein aggregation, compromised neuritic outgrowth and contorted axons with swollen varicosities containing αSyn and tau. We have performed RNA Sequencing (RNA-Seq) of neurons from PD patient and control samples. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
5 Samples

Download data: TXT

Series

Accession:: GSE84684

ID:: 200084684

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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