GEO DataSets

(Submitter supplied) WhiB6 is a transcription factor that regulates expression of genes encoding ESX-1 substrates. We found that in the absence of the genes encoding conserved membrane components of the ESX-1 system, the expression of the whiB6 gene and genes encoding ESX-1 substrates were reduced.

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

10 Samples

Download data: XLSX

(Submitter supplied) Regulation of M. marinum gene expression in an espM deletion strain

Organism:

Mycobacterium marinum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21992

12 Samples

Download data: XLSX

(Submitter supplied) These data show that WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates and ESX-1 substrates are regulated independently from the structural components, both during infection and as a result of active secretion.

Organism:

Mycobacterium tuberculosis H37Rv; Mycobacterium marinum E11; Mycobacterium marinum M

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17280 GPL25983 GPL25982

26 Samples

Download data: TXT

(Submitter supplied) Mice were infected with wild type or ESX-1-deficient (deltaRD1) Mycobacterium marinum. 14 days post infection, infected and uninfected neutrophils from the infected tissue were sorted for single cell RNA sequencing analysis.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19057 GPL24247

8 Samples

Download data: MTX, TSV

(Submitter supplied) The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis. The ESX-1 cluster comprises approximately twenty genes and encodes a specialized secretion apparatus, which releases effectors into the extracellular milieu. The goal of this study is to understand the role of EspL. We show that EspL, a protein of 115 amino acids, is essential for mediating ESX-1-dependent virulence and for stabilization of EspE, EspF and EspH protein levels. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17879

4 Samples

Download data: CSV, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL6719

24 Samples

Download data: TXT

(Submitter supplied) Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL6719

6 Samples

Download data: TXT

(Submitter supplied) Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL6719

7 Samples

Download data: TXT

(Submitter supplied) Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL6719

8 Samples

Download data: TXT

(Submitter supplied) Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL6719

9 Samples

Download data: TXT