Similar studies for GEO DataSets (Select 200104344) - GEO DataSets

(Submitter supplied) Regulatory T cells (Tregs) are responsible for limiting autoimmunity and chronic inflammation. Foxp3 is a transcription factor that acts as a master regulator of Treg development and function. A serendipitous observation led to the realization that a well-characterized Foxp3gfp reporter mouse, which expresses an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accelerated autoimmune diabetes on a NOD background. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
16 Samples

Download data: CEL

Series

Accession:: GSE35164

ID:: 200035164

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002371996.

Mutations from IPEX patients elicit a range of phenotypes in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
182 Samples

Download data: MTX, TBI, TSV, TXT

Series

Accession:: GSE237199

ID:: 200237199

PubMed Full text in PMC Similar studies

Select item 2002371987.

Mutations from IPEX patients elicit a range of phenotypes in mice [scATAC-Seq]

(Submitter supplied) scATAC analysis of mouse Treg from Foxp3 missense mutant mice heterozygous females : R51Q, K199del, R51Q, WT

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: MTX, TBI, TSV, TXT

Series

Accession:: GSE237198

ID:: 200237198

PubMed Full text in PMC Similar studies

Select item 2002258918.

Mutations from IPEX patients elicit a range of phenotypes in mice [RNAseq]

(Submitter supplied) RNAseq analysis of mouse Treg from Foxp3 missense mutant mice hemizygous male and heterozygous female : R51Q, C168Y, K199del, R309Q, F324L, R337Q

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
181 Samples

Download data: TSV

Series

Accession:: GSE225891

ID:: 200225891

PubMed Full text in PMC Similar studies

Select item 2000897449.

Analyses of a mutant FoxP3 allele reveal BATF as a critical transcription factor in the differentiation and accumulation of tissue regulatory T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL1261 GPL18480
47 Samples

Download data: CEL, TXT

Series

Accession:: GSE89744

ID:: 200089744

Select item 20008974310.

Genome-wide maps of FoxP3 binding in FoxP3WT and FoxP3A384T Treg cells

(Submitter supplied) FoxP3 binding sites in Treg cells expressing WT or A384T mutant FoxP3 were examined.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18480
12 Samples

Download data: TXT

Series

Accession:: GSE89743

ID:: 200089743

PubMed Similar studies SRA Run Selector

Select item 20008965611.

Expression data from BATF-deficient Treg cells

(Submitter supplied) FoxP3 is a central regulator of immunological tolerance, controlling the development and function of regulatory T (Treg) cells. To dissect the complex processes orchestrated by FoxP3, we investigated impacts of three autoimmune disease-associated missense FoxP3 mutations in mice. The I363V and R397W mutations were loss-of-function mutations, causing multi-organ inflammation by globally compromising Treg cell physiology. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE89656

ID:: 200089656

Select item 20008965412.

Expression data from Treg cells expressing mutant FoxP3

(Submitter supplied) FoxP3 is a central regulator of immunological tolerance, controlling the development and function of regulatory T (Treg) cells. To dissect the complex processes orchestrated by FoxP3, we investigated impacts of three autoimmune disease-associated missense FoxP3 mutations (i.e., I363V, A384T, R397W) through knock-in mutagenesis in mice. We investigated the impacts of these mutations on Treg cell transcriptome by microarray analysis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE89654

ID:: 200089654

Select item 20008964513.

Expression data from mutant FoxP3-transduced CD4 T cells

(Submitter supplied) FoxP3 is a central regulator of immunological tolerance, controlling the development and function of regulatory T (Treg) cells. To dissect the complex processes orchestrated by FoxP3, we investigated impacts of three autoimmune disease-associated missense FoxP3 mutations in mice. As a initial approach, we retrovirally transduced naïve conventional T (Tconv) cells with WT or mutant (A384T and R397W) FoxP3 and analyzed the gene expression profiles of the transduced T cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
11 Samples

Download data: CEL

Series

Accession:: GSE89645

ID:: 200089645

Select item 20016601714.

Transcriptional profiling of LNGFR.FOXP3-expressing scurfy CD4+ T cells

(Submitter supplied) We reported transcriptional characterization of LNGFR.FOXP3-expressing scurfy CD4+ T cells from lymph nodes, at day 35 after transfer in scurfy males, where they were able to rescue mice from scurfy autoimmune disease.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
22 Samples

Download data: TSV

Series

Accession:: GSE166017

ID:: 200166017

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004774715.

Contribution of histone methylation to the plasticity of human FOXP3+ Treg cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT, WIG

Series

Accession:: GSE47747

ID:: 200047747

PubMed Full text in PMC Similar studies

Select item 20004763616.

Transcriptional profiling of FOXP3+ Treg cells and corresponding FOXP3-losing cells

(Submitter supplied) Natural CD4+FOXP3+ regulatory T (Treg) cells constitute a unique T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. Recent studies provide evidence for the heterogeneity and plasticity of the Treg cell lineage. However, the fate of human Treg cells after loss of FOXP3 expression and the underlying epigenetic mechanisms remain to be fully elucidated. Here, we compared gene expression profiles and histone methylation status on two histone H3 lysine residues (H3K4me3 and H3K27me3) of expanded FOXP3+ and corresponding FOXP3-losing Treg cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: TXT

Series

Accession:: GSE47636

ID:: 200047636

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004751017.

Genome-wide maps of H3K4me3 and H3K27me3 in human FOXP3+ Treg cells and the corresponding FOXP3-losing cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: WIG

Series

Accession:: GSE47510

ID:: 200047510

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019005718.

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL24247
15 Samples

Download data: BED, HIC, MTX, TBI, TSV, TXT

Series

Accession:: GSE190057

ID:: 200190057

PubMed Full text in PMC Similar studies

Select item 20018944219.

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression [HiChIP]

(Submitter supplied) We applied proximity-ligation with chromatin immunoprecipitation (HiChIP) in Treg and closely related conventional CD4+ T cells (Tconv) to map the H3K27Ac, FoxP3 and Yy1 chromatin structures.

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
14 Samples

Download data: HIC

Series

Accession:: GSE189442

ID:: 200189442

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005577320.

Inflammation induced repression of Foxp3-bound chromatin in regulatory T cells [sequencing]

(Submitter supplied) The transcription factor Foxp3 is indispensable for the ability of regulatory T (Treg) cells to suppress fatal inflammation. Here, we characterized the role of Foxp3 in chromatin remodeling and regulation of gene expression in actively suppressing Treg cells in an inflammatory setting. Although genome-wide Foxp3 occupancy of DNA regulatory elements was similar in resting and in vivo activated Treg cells, Foxp3-bound enhancers were poised for repression only in activated Treg cells. more...