GEO DataSets

(Submitter supplied) Autism spectrum disorder(ASD) is a complex neurodevelopmental disorder. Aberrant DNA methylation has been observed in ASD but the mechanisms remain largely unknown. Here, we employed discordant monozygotic twins to investigate the contribution of DNA methylation to ASD etiology. Genome-wide DNA methylation analysis was performed using samples obtained from five pairs of ASD-discordant monozygotic twins, which revealed a total of 2397 differentially methylated genes. more...

Organism:

Homo sapiens

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL16791

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing

Platforms:

GPL13534 GPL16791

10 Samples

Download data: IDAT, TXT

(Submitter supplied) Autism spectrum disorder(ASD) is a complex neurodevelopmental disorder. Aberrant DNA methylation has been observed in ASD but the mechanisms remain largely unknown. Here, we employed discordant monozygotic twins to investigate the contribution of DNA methylation to ASD etiology. Genome-wide DNA methylation analysis was performed using samples obtained from five pairs of ASD-discordant monozygotic twins, which revealed a total of 2397 differentially methylated genes. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

6 Samples

Download data: IDAT, TXT

(Submitter supplied) Two families with monozygotic twins discordant for schizophrenia

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL17148

8 Samples

Download data: GFF, PAIR

(Submitter supplied) this study analyzes the WGBS of twins discordant for non syndromic cleft lip and palate

Organism:

Homo sapiens

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL24676

8 Samples

Download data: COV

(Submitter supplied) Background: Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intrauterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of metabolic genes. In a unique cohort of 17 monozygotic (MZ) monochorionic female twins very discordant for birth weight (relative differences ranging from 21.3-35.7%), we examined if adverse prenatal growth conditions experienced by the smaller co-twins lead to systemic long-lasting DNA methylation changes. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

34 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL23976 GPL17585

8 Samples

Download data: CEL, CHP, IDAT, TXT

(Submitter supplied) Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis involves both genetic and environmental factors. DNA methylation, the most studied epigenetic modification, was shown to play a role in IgAN. In two pairs of IgAN-discordant monozygotic (MZ) twins, here we assessed genome-wide DNA methylation profiling and gene expression profiling in order to characterize DNA methylation changes in IgAN and their potential influences on gene expression.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL23976

4 Samples

Download data: IDAT, TXT

(Submitter supplied) Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis involves both genetic and environmental factors. DNA methylation, the most studied epigenetic modification, was shown to play a role in IgAN. In two pairs of IgAN-discordant monozygotic (MZ) twins, here we assessed genome-wide DNA methylation profiling and gene expression profiling in order to characterize DNA methylation changes in IgAN and their potential influences on gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17585

4 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Genome wide DNA methylation profiling of MZ twins discordant and concordant for BMI. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 485,000 CpGs. Samples included 30 MZ twin pairs discordant for BMI and 10 pairs concordant for BMI.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

96 Samples

Download data: TXT

(Submitter supplied) Genome wide DNA methylation profiling with the HumanMethylation450 BeadChip (450k) of peripheral blood samples of 46 adult female monozygotic twin-pairs obtained at the same time point. Samples included 41 healthy females (not diagnosed with cancer to date) paired with their co-twin diagnosed with cancer within a 5 year window around the time of sampling as well as 5 extra pairs with a co-twin diagnosed with cancer within 11 to 5 years prior to blood sampling.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

92 Samples

Download data: TXT

(Submitter supplied) Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum disorders, we have recently completed large-scale methylation profiling by CpG island microarray analysis of lymphoblastoid cell lines (LCL) derived from monozygotic twins discordant for diagnosis of autism and their nonautistic siblings. Methylation profiling revealed many candidate genes differentially methylated between discordant MZ twins as well as between both twins and nonautistic siblings. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL10342

31 Samples

Download data: MEV

(Submitter supplied) Background: The autism spectrum includes a set of complex multigenic developmental disorders that severely impact the development of language, non-verbal communication, and social skills, and are associated with odd, stereotyped, repetitive behavior and restricted interests. To date, diagnosis of these neurologically based disorders relies predominantly upon behavioral observations often prompted by delayed speech or aberrant behavior, and there are no known genes that can serve as definitive biomarkers for the disorders. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3427

19 Samples

Download data

(Submitter supplied) Study of cell type specific DNA Methylation profiles for 4 cell types.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL20873

18 Samples

Download data: XYS

(Submitter supplied) Study of changes in DNA Methylation in monozygotic Rheumatoid Arthritis discordant twins and ACPA+/- discordant twins

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL20873

24 Samples

Download data: XYS

(Submitter supplied) Peripheral blood from thirty-four monozygotic twin subjects from the general population (n = 17 twin pairs) was collected for epigenomic analysis via Illumina Infinium HumanMethylation450 Beadchip. All subjects were screened for DSM-IV based criteria for both current and lifetime psychiatric disorders. Out of 17 twin pairs, there were: 7 healthy twin pairs where none of the twins of a pair met criteria for any DSM-IV disorder; 6 discordant twin pairs where only one of the twins of each pair met diagnostic criteria; and 4 concordant twin pairs where both twins of a pair met clinical DSM-IV based criteria.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

34 Samples

Download data: IDAT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL5082 GPL6244

68 Samples

Download data: BED, CEL

(Submitter supplied) Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci reponsible for the phenotypical differences. We performed comprehensive DNA methylation analysis in monozygotic twins manifesting differences in IQ scores. Genes with significantly different methylation status are considered as candidates related to human intelligence.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL5082

34 Samples

Download data: BED, CEL

(Submitter supplied) Human intelligence demonstrates one of the highest heritabilities among human quantitative traits. Phenotypically discordant monozygotic twins provide a way to identify loci responsible for normal-range intelligence. We conducted array-based genome-wide gene expression analysis aiming to identify genes displaying significant difference among monozygotic twin pairs manifesting between-co-twins IQ differences.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

34 Samples

Download data: CEL

(Submitter supplied) Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from twelve 53–80 year-old monozygotic discordant twin pairs.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

32 Samples

Download data: TXT