GEO DataSets

(Submitter supplied) Transcriptional profiling of Mycobacterium tuberculosis H37Ra::pTetR-yidC (Test) compared with Mycobacterium tuberculosis H37Ra::pTetR (Control) bacteria after 4 days of treatment with 50ng/ml ATc with shaking at 200rpm at 37°C.

Organism:

Mycobacterium tuberculosis; Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platform:

GPL19545

3 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of M. smegmatis and Dcrp1 grown in flasks on Hartmans de Bont medium supplemented with 10 mM glycerol. Transcriptional profiling of M.smegmatis HLA102 harboring tetracycline inducible vector pMind containing the Crp2 and M. smegmatis harboring pMind grown in flasks on Hartmans de Bont medium supplemented with 10 mM glycerol

Organism:

Mycolicibacterium smegmatis; Mycolicibacterium smegmatis MC2 155

Type:

Expression profiling by array

Platform:

GPL18444

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mycolicibacterium smegmatis MC2 155; Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platforms:

GPL14591 GPL14580

2 Samples

Download data: GPR

(Submitter supplied) Transcriptional profile of Mycobacterium tuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress.

Organism:

Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platform:

GPL14591

1 Sample

Download data: GPR

(Submitter supplied) Transcriptional profile of Mycobacterium smegmatis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress.

Organism:

Mycolicibacterium smegmatis MC2 155; Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platforms:

GPL14591 GPL14580

2 Samples

Download data: GPR

(Submitter supplied) RNA polymerase (RNAP) binding protein RbpA contributes to the formation of stable RNAP-promoter open complexes (RPo) and is essential for viability in mycobacteria. Based on structural and biochemical data, four domains have been identified in the RbpA protein: a N-terminal tail (NTT) domain of unknown function, a core domain (CD) that contacts the RNAP β’ subunit in a recently solved crystal structure, a basic linker (BL) that binds DNA, and a s-interaction domain (SID) that binds group I and group II s-factors. more...

Organism:

Mycolicibacterium smegmatis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23277

12 Samples

Download data: XLSX

(Submitter supplied) Mycobacterium tuberculosis (Mtb) assimilates cholesterol during chronic infection, and its in vitro growth in presence of cholesterol requires Mycofactocin (MFT) biosynthesis genes, although the basis of this requirement is unclear. MFT belongs to the class of ribosomally synthesized and post-translationally modified peptides conserved in many Actinobacteria, and its biological function and structure requires further confirmation. more...

Organism:

Mycobacterium tuberculosis variant bovis; Mycobacterium tuberculosis H37Rv; Mycolicibacterium smegmatis

Type:

Expression profiling by array

Platforms:

GPL25686 GPL25708

30 Samples

Download data: TXT

(Submitter supplied) Purpose: CsoR, a copper responsive negative regulator of Mycobacterium tuberculosis has been shown to respond to copper and bind to its own regulon in in vitro experiments. Here we examine the role of CsoR in vivo by examining the impact of deletion of csoR on the host transcriptome. Methods: csoR was knocked out of M. tuberculosis H37Rv using the specialized transduction method developed by Bardarov et al (2002), followed by removal of the hygromycin marker with plasmid pYUB870. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18768

4 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Mycobacterium smegmatis comparing the effects of wild type levels of CarD expression with CarD depletion. Transcriptional profile of the mgm1701 control strain was compared with that of mgm1703, a strain where CarD transcription is regulated by a Tet-On system. Both strains were grown in the absence of anhydrotetracline for 13 hours in nutrient rich broth to allow for depletion of CarD transcription in mgm1703.

Organism:

Mycolicibacterium smegmatis

Type:

Expression profiling by array

Platform:

GPL8356

1 Sample

Download data: GPR

(Submitter supplied) Transcription analysis of ΔpknK mutant (LIX11) versus wild type H37Rv during logarithmic and stationary phase growth. This will elucidate the genes regulated by PknK during transition from logarithmic growth to stationary phase growth.

Organism:

Mycobacterium tuberculosis H37Rv

Type:

Expression profiling by array

Platforms:

GPL13237 GPL15500

5 Samples

Download data: TXT

(Submitter supplied) Since VirS was shown to be upregulated in acidic conditions and MtbΔvirS displayed defect in growth at pH4.5, we performed microarray at pH 6.6 and pH 4.5 to study the role of VirS in regulating gene expression at acidic pH.

Organism:

Mycobacterium tuberculosis H37Rv; Mycobacterium tuberculosis str. Erdman = ATCC 35801

Type:

Expression profiling by array

Platform:

GPL21002

16 Samples

Download data: TXT, XLSX

(Submitter supplied) pepD is regulated by a 2CS, MprAB, and impacts upon the regulation of sigE, an important M.tb sigma factor. Here we examine the global impact of gene regulation in a delta pepD mutant strain.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL5774

5 Samples

Download data: TXT

(Submitter supplied) We characterized the variation of M. tuberculosis transcriptional profile in response to inhibitory and subhinibitory concentrations of vancomycin.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL4057

12 Samples

Download data

(Submitter supplied) Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic conditions within the host, but the response of M. tuberculosis to a hypoxic signal remains poorly characterized. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL2787

6 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Mycobacterium tuberculosis CDC1551 comparing control butyric acid-treated cells with 20mM db-cAMP treated cells after 2hrs of treatment with shaking at 200rpm at 37C.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platform:

GPL18195

3 Samples

Download data: TXT

(Submitter supplied) Gene expression is evaluated over roughly 1.5 cell cycles in a temperature-sensitive dnaA mutant of M. tuberculosis H37Rv to identify genes with periodic expression, or clusters of genes whose expression peaks at different timepoints correlating with distinct cell-cycle events like chromosome replication, septum formation, divisome assembly, and cytokinesis.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25317

64 Samples

Download data: XLSX

(Submitter supplied) The virulence of Mycobacterium tuberculosis (M.tb) is related to many factors, including intra-cellular survival, cell wall permeability, and cell envelope proteins. However, the biological function of M.tb membrane protein Rv1476 remains unclear. To investigate the potential role played by Rv1476, we constructed an Rv1476 overexpression strain and found overexpression of Rv1476 enhanced the intracellular survival of M.tb, while having no impact on the growth rate in vitro. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28038

4 Samples

Download data: TXT