GEO DataSets

(Submitter supplied) Candida albicans is a commensal yeast of the human gut, which is tolerated by the immune system, but has the potential to become an opportunistic pathogen. One way in which C. albicans achieves this duality is through the concealing, or exposure of cell wall associated pathogen-associated molecular patterns (PAMPs) in response to host derived environment cues (pH, hypoxia, lactate). This cell wall remodelling allows C. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24129

33 Samples

Download data: XLSX

(Submitter supplied) Wild type (CAI10) and phr1 null mutant (CAS10) were analyzed at 0, 1, 3 and 5 hours after the shift of blastospores to Hyphae inducing conditions

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL9545

24 Samples

Download data: TXT

(Submitter supplied) Cryptococcus neoformans is a ubiquitous free-living soil yeast and opportunistic pathogen that causes ~223,100 cases of cryptococcal meningitis per year, killing over 180,000 people. The pathogenicity of C. neoformans relies on its adaptation to the host conditions. An important difference between its natural environment and the mammalian host is the concentration of CO2. CO2 levels in the host fluctuate around 5%, which is ~125-fold higher than in ambient air. more...

Organism:

Cryptococcus neoformans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21073

18 Samples

Download data: XLSX

(Submitter supplied) Purpose: Candida albicans avidly uses multiple carbon sources that are less preferred by related species. This project compared transcriptional profiles of cells growing in media containing these nutrients relative to glucose Methods: C. albicans strain SC5314 was incubated in minimal YNB media containing 2% glucose, casamino acids, glutamate or a-ketoglutarate for five hours. RNA was prepared and subjected to deep sequencing. more...

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15645

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans

Type:

Other; Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL19932 GPL17892 GPL17420

32 Samples

Download data: GPR

(Submitter supplied) Candida albicans is part of the human gastrointestinal (GI) microbiota. To better understand how C. albicans efficiently establishes GI colonisation, we competitively challenged growth of 572 signature-tagged strains (~10% genome coverage), each conditionally overexpressing a single gene, in the murine gut. We identified CRZ2, a transcription factor whose overexpression and deletion respectively increased and decreased early GI colonisation. more...

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL17892

2 Samples

Download data: GPR

(Submitter supplied) Candida albicans is part of the human gastrointestinal (GI) microbiota. To better understand how C. albicans efficiently establishes GI colonisation, we competitively challenged growth of 572 signature-tagged strains (~10% genome coverage), each conditionally overexpressing a single gene, in the murine gut. We identified CRZ2, a transcription factor whose overexpression and deletion respectively increased and decreased early GI colonisation. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL19932

22 Samples

Download data: GPR

(Submitter supplied) Candida albicans is part of the human gastrointestinal (GI) microbiota. To better understand how C. albicans efficiently establishes GI colonisation, we competitively challenged growth of 572 signature-tagged strains (~10% genome coverage), each conditionally overexpressing a single gene, in the murine gut. We identified CRZ2, a transcription factor whose overexpression and deletion respectively increased and decreased early GI colonisation. more...

Organism:

Candida albicans

Type:

Other

Platform:

GPL17420

12 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of Candida albicans SC5314 comparing C. albicans grown in RPMI1640 or in RPMI1640 with 100ug/ml AAT. Goal was to determine the effects of AAT on global C. albicans gene expression.

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL19289

8 Samples

Download data: TXT

(Submitter supplied) The fungal pathogen Candida albicans produces dark-pigmented melanin when grown in a basal medium containing 1 mM l-DOPA as melanin substrate. In the widely used C. albicans strain SC5314, melanin appeared after 3-4 days of incubation in l-DOPA medium. The experiment was designed to reveal cadidate genes associated with melanin biosynthesis by expression profiling at different times of growth with and without L-DOPA added to the medium. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL7476

16 Samples

Download data: TXT

(Submitter supplied) We report the expression levels of transcripts for two alleles of 6,211 genes in log-phase growing cells of the wild type SN148 and the crz1/crz1 with or without 0.2M CaCl2 treatment.We find that as compared to the wild type cells without 0.2M CaCl2 treatment, there are 828 genes upregulated in the wild type cells with 0.2M CaCl2 treatment.

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23041

4 Samples

Download data: XLSX

(Submitter supplied) We examined the early gene expression profiles (30 min) of log-phase wild-type C. albicans growing in YPD at 30 °C in response to respiration inhbitors 1mM SNP, 0.5 mM SHAM, or 1 mM SNP+ 0.5 mM SHAM combination

Organism:

Candida albicans

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22403

12 Samples

Download data: TXT

(Submitter supplied) To investigate the roles of Sfp1, we used a whole-genome DNA microarray to compare gene expression patterns between the sfp1-deleted and wild-type strains. Among the upregulated genes, a subset of genes is involved in oxidative stress response, including CAP1, SSK1, and SHO1. The CAP1 gene product is a bZip transcription factor involving in regulation of antioxidant gene expression. The SSK1 and SHO1 gene encodes a response regulator of two-component system and an adaptor protein in the Hog1 MAPK signaling pathway, respectively. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL26225

4 Samples

Download data: TXT