Similar studies for GEO DataSets (Select 200146683) - GEO DataSets

Select item 2001466831.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
12 Samples

Download data

Series

Accession:: GSE146683

ID:: 200146683

PubMed Full text in PMC Similar studies

Select item 2001466822.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties [scRNA-seq]

(Submitter supplied) Tissue-resident macrophages are a diverse population of cells that perform specialized functions including sustaining tissue homeostasis and tissue surveillance. Here we report an interstitial subset of CD169+ lung-resident macrophages that are transcriptionally and developmentally distinct from alveolar macrophages (AMs). They are primarily localized around the airways and are found in close proximity to the sympathetic nerves located in the bronchovascular bundle. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: MTX, TSV

Series

Accession:: GSE146682

ID:: 200146682

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001466813.

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties [bulk-seq]

(Submitter supplied) Tissue-resident macrophages are a diverse population of cells that perform specialized functions including sustaining tissue homeostasis and tissue surveillance. Here we report an interstitial subset of CD169+ lung-resident macrophages that are transcriptionally and developmentally distinct from alveolar macrophages (AMs). They are primarily localized around the airways and are found in close proximity to the sympathetic nerves located in the bronchovascular bundle. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE146681

ID:: 200146681

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000769994.

Capacity of yolk sac macrophages, fetal liver and adult monocytes to colonize an empty niche and develop into functional tissue resident macrophages

(Submitter supplied) Tissue-resident macrophages can derive from yolk sac macrophages, fetal liver monocytes or adult bone marrow monocytes. Whether these precursors can give rise to transcriptionally identical alveolar macrophages is unknown. Here, we transferred traceable yolk sac macrophages, fetal liver monocytes, adult bone marrow monocytes or adult alveolar macrophages as a control, into the empty alveolar macrophage niche of neonatal Csf2rb-/- mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
36 Samples

Download data: CEL

Series

Accession:: GSE76999

ID:: 200076999

Select item 2000537875.

Gene expression in cardiac macrophages

(Submitter supplied) Three cardiac macrophage subsets and blood ly6chi monocytes were sorted to compare gene expression at steady state.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
16 Samples

Download data: TXT

Series

Accession:: GSE53787

ID:: 200053787

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001886476.

Three tissue resident macrophage subsets co-exist across organs with conserved origins and lifecycles

(Submitter supplied) Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual tissues contain heterogeneous subpopulations, and how these subpopulations are related is unclear. We asked whether common transcriptional and functional elements could reveal an underlying framework across tissues. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
14 Samples

Download data: MTX, TSV

Series

Accession:: GSE188647

ID:: 200188647

PubMed Similar studies SRA Run Selector

Select item 2000474737.

Global gene expression profiling using total RNA [BMM, MPI and SPG]

(Submitter supplied) Differentiation of myeloid progenitor cells leads to distinct populations of mononuclear phagocytes.Various macrophages exhibit distinct biological properties. Here wanted to delineate and characterize gene expression patterns in bone marrow derived macrophages Here wanted to delineate and characterize gene expression patterns in two newly established, self-renewing, in vitro grown non-transformed lines (MPI cells) and in the SP37A3 immature myeloid dendritic cell line. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE47473

ID:: 200047473

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001987788.

The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11202 GPL21493
42 Samples

Download data: TXT

Series

Accession:: GSE198778

ID:: 200198778

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001987719.

Analysis of resident peritoneal macrophage's transcriptome in WT and CGD mice

(Submitter supplied) The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomatous disease (CGD), associated with microbial infections and inflammatory disorders, often involving the lung. Alveolar macrophages (AM) are the predominant immune cell in the airways at steady state, and limiting their activation is important given constant exposure to inhaled materials, yet the importance of NOX2 in this process is not well-understood. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
12 Samples

Download data: TXT

Series

Accession:: GSE198771

ID:: 200198771

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019876910.

Bronchoalveolar lavage alveolar macrophage subset transcriptomes in WT and NOX2-knockout mice

(Submitter supplied) The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomatous disease (CGD), associated with microbial infections and inflammatory disorders, often involving the lung. Alveolar macrophages (AM) are the predominant immune cell in the airways at steady state, and limiting their activation is important given constant exposure to inhaled materials, yet the importance of NOX2 in this process is not well-understood. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
15 Samples

Download data: TXT

Series

Accession:: GSE198769

ID:: 200198769

PubMed Full text in PMC Similar studies

Select item 20019876811.

Genome-wide epigenome mapping in alveolar macrophages (CD45+ Siclec F+ CD11c+) from WT (4wks and 12 wks) and CGD (4wks and 12 wks) mice

(Submitter supplied) The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomatous disease (CGD), associated with microbial infections and inflammatory disorders, often involving the lung. Alveolar macrophages (AM) are the predominant immune cell in the airways at steady state, and limiting their activation is important given constant exposure to inhaled materials, yet the importance of NOX2 in this process is not well-understood. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
15 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE198768

ID:: 200198768

PubMed Full text in PMC Similar studies

Select item 20008876812.

Identification of PPARG regulated genes in human GM-CSF-primed monocyte-derived macrophages

(Submitter supplied) Identification of PPARG regulated genes in human GM-CSF polarized monocyte-derived macrophages by siRNA knock-down approaches.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
6 Samples

Download data: TXT

Series

Accession:: GSE88768

ID:: 200088768

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022566813.

Coordinated chemokine expression defines macrophage subsets across tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL18573
29 Samples

Download data

Series

Accession:: GSE225668

ID:: 200225668

PubMed Similar studies

Select item 20022566714.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: mTumor]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225667

ID:: 200225667

PubMed Similar studies

Select item 20022566615.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: mSk]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225666

ID:: 200225666

PubMed Similar studies

Select item 20022566516.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: mPL]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225665

ID:: 200225665

PubMed Similar studies

Select item 20022566417.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: mLu]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225664

ID:: 200225664

PubMed Similar studies

Select item 20022566318.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: mBAL]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225663

ID:: 200225663

PubMed Similar studies

Select item 20022566219.

Coordinated chemokine expression defines macrophage subsets across tissues [scRNA-seq: hSk]

(Submitter supplied) Lung-resident macrophages, which include alveolar macrophages and interstitial macrophages (IMs), exhibit a high degree of diversity, generally attributed to different activation states, and often complicated by the influx of monocytes into the pool of tissue-resident macrophages. To gain a deeper insight into the functional diversity of IMs, here we perform comprehensive transcriptional profiling of resident IMs and reveal ten distinct chemokine-expressing IM subsets at steady state and during inflammation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL18573
6 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE225662

ID:: 200225662

PubMed Similar studies

Select item 20010909920.

Next Generation Sequencing Facilitates Quantitative Analysis of the Effect of GM-CSF on the Transcriptomes of Alveolar and Exudative Lung Macrophages from Influenza-infected C57BL/6 Mice

(Submitter supplied) The transcriptomes of FACS-sorted siglec-F+ alveolar macrophages and siglec-f- CD11b+ exudative macrophages from inducible airway GM-CSF over-expressing transgenic mice (DTGM) were compared to non-inducible littermate controls during influenza A virus infection.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
26 Samples

Download data: TXT

Series

Accession:: GSE109099

ID:: 200109099

PubMed Full text in PMC Similar studies SRA Run Selector

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