Similar studies for GEO DataSets (Select 200181050) - GEO DataSets

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Items: 20

Select item 2001810501.

Analysis of microRNA transcriptomic changes in ethanol-exposed human embryonic stem cell (hESC)-derived cortical interneurons using small RNA sequencing

(Submitter supplied) Purpose: The goal of this study to use ethanol-exposed human embryonic stem cell (hESC)-derived neural cells as models to investigate microRNA expression changes in the brains of subjects with alcohol use disorder (AUD). Methods: hESCs were differentiated into neural cells (mainly cortical interneurons), which were then cultured in media with or without ethanol (50-100 mM) for 7 days (by duplicate experiments). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE181050

ID:: 200181050

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Select item 2001826492.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem ventral tegmental area (VTA) of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem ventral tegmental area of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE182649

ID:: 200182649

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Select item 2001824403.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem putamen of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem putamen of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. Front Genet 2019; 10, 614). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE182440

ID:: 200182440

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Select item 2001822234.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem nucleus accumbens of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem nucleus accumbens of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE182223

ID:: 200182223

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Select item 2001821735.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem prefrontal cortex of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem prefrontal cortex of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE182173

ID:: 200182173

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Select item 2001819826.

Profiling of transcriptomic changes using seq in postmortem brains of subjects with alcohol use disorder

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
384 Samples

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Series

Accession:: GSE181982

ID:: 200181982

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Select item 2001819817.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem amygdala of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem amygdala of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. Front Genet 2019; 10, 614). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE181981

ID:: 200181981

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Select item 2001818138.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem cerebellum of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem cerebellum of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. Front Genet 2019; 10, 614). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE181813

ID:: 200181813

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Select item 2001818049.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem hippocampus of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem hippocampus of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. Front Genet 2019; 10, 614). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE181804

ID:: 200181804

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Select item 20018174110.

Profiling of mRNA transcriptomic changes using RNA-seq in postmortem caudate nucleus of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine mRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from postmortem caudate nucleus of 12 AUD and 12 control subjects. rRNA depletion RNA sequencing was performed and the sequence reads were processed using the bulk RNA-seq processing pipeline Pipeliner workflow (Federico et al. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
24 Samples

Download data: TXT

Series

Accession:: GSE181741

ID:: 200181741

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Select item 20018152011.

Profiling of miRNA transcriptomic changes using small RNA-seq in 8 regions of postmortem brains of subjects with alcohol use disorder

(Submitter supplied) Purpose: The goal of this study to examine miRNA transcriptomic changes in reward-related brain regions of subjects with alcohol use disorder. Methods: Total RNAs were extracted from 8 reward-related regions of postmortem brains of 12 AUD and 12 control subjects (8x24=192 tissue samples). Small RNA sequencing was performed and the sequence reads were processed using the Comprehensive Analysis Pipeline for miRNA Sequencing Data (CAP-miRseq) workflow. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
192 Samples

Download data: TXT

Series

Accession:: GSE181520

ID:: 200181520

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Select item 20018104912.

Analysis of mRNA transcriptomic changes in ethanol-exposed human embryonic stem cell (hESC)-derived cortical interneurons using ribosome depletion RNA sequencing

(Submitter supplied) Purpose: The goal of this study to use ethanol-exposed human embryonic stem cell (hESC)-derived neural cells as models to investigate mRNA expression changes in the brains of subjects with alcohol use disorder (AUD). Methods: hESCs were differentiated into neural cells (mainly cortical interneurons), which were then cultured in media with or without ethanol (50-100 mM) for 7 days (by duplicate experiments). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE181049

ID:: 200181049

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Select item 20018072213.

Profiling mRNA transcriptomic changes using Affymetrix Clarion D assay in 6 regions of postmortem brains of subjects with alcohol use disorder

(Submitter supplied) Chronic alcohol consumption may alter mRNA transcriptomic changes in reward-related brain regions, leading to neuroadaptations and thus increased risk of AUD. We used the Affymetrix Clariom™ D Assay Array to map mRNA transcriptome profiles in six reward-related regions of postmortem brains of AUD and control subjects and identified differentially expressed mRNAs.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
96 Samples

Download data: CEL

Series

Accession:: GSE180722

ID:: 200180722

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Select item 20018070014.

Profiling miRNA transcriptomic changes using Affymetrix miRNA4.0 in 6 regions of postmortem brains of subjects with alcohol use disorder

(Submitter supplied) Chronic alcohol consumption may alter miRNA transcriptome profiles in reward-related brain regions. Given that miRNAs can regulate the expression of their target coding genes (or mRNAs) at the post-transcriptional level, alcohol-induced miRNA expression change may influence the expression of their targets mRNAs that are involved in alcohol use disorder (AUD)-related pathways, leading to increased risk of AUD. more...

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
96 Samples

Download data: CEL

Series

Accession:: GSE180700

ID:: 200180700

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Select item 20005042715.

Gene (mRNA) expression profiling in frontal cortex of ethanol-treated mice

(Submitter supplied) Analysis of early stages of alcohol dependence at the gene expression level. The hypothesis tested in the present study was that ethanol-treatment impact gene expression in a mouse model of high ethanol consumption. Results provide important information of genes and pathways being affected by ethanol actions in the mouse frontal cortex.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
32 Samples

Download data: TXT

Series

Accession:: GSE50427

ID:: 200050427

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Select item 20004937616.

Profiling Transcriptomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

(Submitter supplied) Analysis of transcriptiomic alternations related with alcohol use disorders (AUDs). The hypothesis is that chronic alcohol consumption might alter genome-wide gene expression patterns. The results suggest that differential gene expression in the prefrontal cortex is implicated in neuroadaptations to alcohol.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
48 Samples

Download data: TXT

Series

Accession:: GSE49376

ID:: 200049376

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Select item 20009060817.

MicroRNA expression data from CIE-vapor treated mice

(Submitter supplied) We examined microRNA expression profiles in amygdala (AMY), nucleus accumbens (NAC) and prefrontal cortex (PFC) of male C57BL/6J mice exposed to 4 cycles of chronic intermittent ethanol (CIE) vapor. Animals were sacrificed at 0, 8, and 120 hr following the last ethanol exposure.

Organism:: Mus musculus; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL16384
139 Samples

Download data: CEL, XLSX

Series

Accession:: GSE90608

ID:: 200090608

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Select item 20019874018.

Comprehensive identification of RNA transcripts and construction of RNA networks in chronic obstructive pulmonary disease

(Submitter supplied) Here, we report a comprehensive analysis of dysregulated mRNAs, lncRNAs, miRNAs and circRNAs in peripheral blood of COPD patients with high-throughput RNA sequencing. We mapped about 50~80 million sequence reads per sample to the human genome. GSEA analysis showed that these dysregulated RNAs correlate with several critical biological processes such as RNA modification, and RNA metabolism. RT-qPCR (SYBR Green assays) with more clinical COPD samples were used for the validation of some dysregulated RNAs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: BED, TXT

Series

Accession:: GSE198740

ID:: 200198740

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Select item 20003598219.

Identifying microRNA-mRNA regulatory networks in colorectal cancer by a combination of expression profile and bioinformatics analysis

(Submitter supplied) A multi-step approach combining microarray profile and bioinformatics analysis was adopted to identify the CRC specific miRNA-mRNA regulatory network. First, differentially expressed miRNAs and mRNAs were found out in CRC samples compared with normal epithelial tissues by miRNA and mRNA microarray respectively. Secondly the target mRNAs of dysregualted miRNA were identified by a combination of Pearson correlation coefficient between the expression level of miRNAs and mRNAs and online miRNA target predicting databases. more...