Similar studies for GEO DataSets (Select 200188325) - GEO DataSets

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Items: 20

Select item 2001883251.

CD19-CAR T cells undergo exhaustion epigenetic programming in patients with acute lymphoblastic leukemia

(Submitter supplied) Zebley et al. show that CD8+ CD19-CAR T cells undergo genome-wide DNA methylation changes during an anti-tumor response in patients with B-cell acute lymphoblastic leukemia (ALL). Post-infusion CAR T cell differentiation involves acquisition of DNA methylation programs associated with effector function, repression of memory potential, and transition toward exhaustion.

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24676
30 Samples

Download data: TXT

Series

Accession:: GSE188325

ID:: 200188325

PubMed Full text in PMC Similar studies

Select item 2001714422.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [WGBS]

(Submitter supplied) Defciency of Regnase-1 enhances CAR-T cell persistence and anti-tumor ability

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: BED

Series

Accession:: GSE171442

ID:: 200171442

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001550213.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL24247 GPL23038
40 Samples

Download data: BED, CEL

Series

Accession:: GSE155021

ID:: 200155021

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001550204.

Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

(Submitter supplied) transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice. TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
10 Samples

Download data: CEL

Series

Accession:: GSE155020

ID:: 200155020

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Select item 2001549425.

Regnase-1 KO CAR T cell reprogramed to memory-like cells

(Submitter supplied) transcriptional profiling was performed on WT and KO CAR T cells isolated 21 days after co-transfer into tumor bearing mice. Regnase-1 KO CAR T cell reprogramed to memory-like cells long-term after tumor priming in vivo compared to WT CAR T cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE154942

ID:: 200154942

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Select item 2001548596.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [Microarray Expression]

(Submitter supplied) transcriptional profiling was performed on WT and KO CAR T cells isolated 7 days after co-transfer into mice with or without tumors. Regnase-1 KO CAR T cells undergoing a tumor-dependent shift from an effector to memory-like phenotype

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
19 Samples

Download data: CEL

Series

Accession:: GSE154859

ID:: 200154859

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Select item 2001764187.

Regulatory programs of B-cell activation and germinal center reaction allow for B-ALL escape from CD19 CAR T-cell therapy

(Submitter supplied) CAR T-cell therapy has led to tremendous successes in the treatment of B-cell malignancies. However, 30%-50% of treated patients relapse – often with reduced target antigen expression. We report that anti-CD19 CAR T-cells cause a rapid reduction of CD19 expression within hours in CAR-T exposed CD19+ B-ALL cells. Initially, anti-CD19 CAR T-cells cause CD19 clusters at the T-cell – leukemia cell interface followed by CD19 internalization and decreased CD19 surface expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
973 Samples

Download data: CSV

Series

Accession:: GSE176418

ID:: 200176418

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001794148.

Epigenetic profiling and response to CD19 chimeric antigen receptor (CAR) T-cell therapy in B-cell malignancies

(Submitter supplied) Chimeric antigen receptor (CAR) T-cells directed against CD19 (CART19) are effective in relapsed/refractory (R/R) B-cell malignancies. Not all patients show treatment efficacy, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. Our objective was to determine the effect of epigenetic changes in CART19 cells on the clinical course of B-cell malignancy patients treated with adoptive therapy. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
157 Samples

Download data: CSV

Series

Accession:: GSE179414

ID:: 200179414

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Select item 2001972159.

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

(Submitter supplied) We report 101,326 single cell transcriptomes and surface protein landscape from the Chimeric antigen receptor-modified (CAR) T infusion products of 12 pediatric ALL patients upon CAR antigen-specific stimulation in comparison with TCR-mediated activation and controls.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL20301
120 Samples

Download data: RDS

Series

Accession:: GSE197215

ID:: 200197215

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Select item 20024889210.

RNA-seq analysis of gene expression regulated by LSD1 in CD8+ T cells

(Submitter supplied) In the RNA-seq analyses of in vitro activated and expanded CD8+ T cells, we found that GSK treatment significantly altered the transcriptome, with 241 genes upregulated and 426 genes downregulated respectively . Gene Ontology (GO) enrichment analysis revealed that the upregulated genes were highly enriched in biological processes related to cell killing and cytokine production.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE248892

ID:: 200248892

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Select item 20024889111.

ChIP-seq analysis of gene expression regulated by LSD1 in CD8+ T cells

(Submitter supplied) ChIP-seq assay was performed with GSK- or Vehicle-treated CD8+ T cells to interrogate the genome-wide distribution of LSD1, H3K4me1, H3K4me2, H3K4me3, H3K27ac, and Pol II, and their alterations in response to LSD1 inhibition.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL28330
16 Samples

Download data: BROADPEAK, BW, NARROWPEAK

Series

Accession:: GSE248891

ID:: 200248891

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Select item 20024696012.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [scRNA/CITE-seq]

(Submitter supplied) Single cell gene expression profile of WT and SUV39H1-edited CAR T cells at pre-infusion (Day 0), day 9 and day 16 post infusion in tumor (NALM6) bearing NSG mice

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL24676
48 Samples

Download data: RDS

Series

Accession:: GSE246960

ID:: 200246960

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Select item 20024518713.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
64 Samples

Download data

Series

Accession:: GSE245187

ID:: 200245187

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Select item 20024518614.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [ATAC-Seq]

(Submitter supplied) Comparing genome accessibility profiles (ATACseq) of WT and SUV39H1-edited CAR T cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: TXT

Series

Accession:: GSE245186

ID:: 200245186

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Select item 20024518415.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [RNA-Seq]

(Submitter supplied) Comparing transcriptional profiles (RNAseq) of WT and SUV39H1-edited CAR T cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: TXT

Series

Accession:: GSE245184

ID:: 200245184

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021026516.

BLIMP1 and NR4A3 Transcription Factors Reciprocally Regulate Antitumor CAR T-cell Stemness and Exhaustion

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
24 Samples

Download data: BW, TSV

Series

Accession:: GSE210265

ID:: 200210265

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Select item 20021026417.

BLIMP1 and NR4A3 Transcription Factors Reciprocally Regulate Antitumor CAR T-cell Stemness and Exhaustion [RNA-Seq]

(Submitter supplied) Chimeric antigen receptor (CAR) T-cells have not induced meaningful clinical responses in solid tumor indications. Loss of T-cell stemness, poor expansion capacity and exhaustion during prolonged tumor antigen exposure are major causes of CAR T-cell therapeutic resistance. scRNA-sequencing analysis of CAR T-cells from a first-in-human trial in metastatic prostate cancer identified two distinct and independently validated cell states associated with antitumor potency or lack of efficacy. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
24 Samples

Download data: CSV, TSV

Series

Accession:: GSE210264

ID:: 200210264

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Select item 20021026218.

BLIMP1 and NR4A3 Transcription Factors Reciprocally Regulate Antitumor CAR T-cell Stemness and Exhaustion [ATAC-Seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: BW

Series

Accession:: GSE210262

ID:: 200210262

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Select item 20018456819.

Deleting DNMT3A in CAR T cells prevents exhaustion and 1 enhances antitumor activity

(Submitter supplied) Whole-genome bisulfite sequencing data generated from WT and DNMT3A KO or IL-10 KO CAR T cells. These data were generate at early (week 1) and later (week 4) time points during in vitro serial stimulation of the CAR T cells, or after infusion into tumor bearing mice. These data document the DNA methylation changes that are coupled to the functional decline in CAR T cells during their sustained stimulation, and the causal nature of DNMT3A-specific methylation in mediating the functional impairment of the CAR T cells.