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| Status |
Public on Nov 08, 2021 |
| Title |
CD19-CAR T cells undergo exhaustion epigenetic programming in patients with acute lymphoblastic leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Zebley et al. show that CD8+ CD19-CAR T cells undergo genome-wide DNA methylation changes during an anti-tumor response in patients with B-cell acute lymphoblastic leukemia (ALL). Post-infusion CAR T cell differentiation involves acquisition of DNA methylation programs associated with effector function, repression of memory potential, and transition toward exhaustion.
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| Overall design |
4 Pre-infusion samples, 13 GMP samples, 4 week1 after GMP samples, 5 week2 after GMP samples, 3 week3 after GMP samples, 1 week4 after GMP sample.
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| |
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| Contributor(s) |
Zebley CC, Gottschalk S, Youngblood B |
| Citation(s) |
34852226 |
| |
| Submission date |
Nov 05, 2021 |
| Last update date |
Feb 07, 2022 |
| Contact name |
Tian Mi |
| E-mail(s) |
[email protected]
|
| Organization name |
St. Jude Children's Research Hospital
|
| Department |
Immunology
|
| Street address |
262 Danny Thomas Pl MS351
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA778264 |
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