Similar studies for GEO DataSets (Select 200198423) - GEO DataSets

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Items: 20

Select item 2001984231.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021
21 Samples

Download data: BED, TAR

Series

Accession:: GSE198423

ID:: 200198423

PubMed Full text in PMC Similar studies

Select item 2001984222.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas [scRNA-seq]

(Submitter supplied) Purpose: We show that genetic ablation or pharmacological inhibition of H3K9-methyl transferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: RDS, TAR

Series

Accession:: GSE198422

ID:: 200198422

PubMed Full text in PMC Similar studies

Select item 2001984213.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas [ATAC-seq]

(Submitter supplied) Purpose: We show that genetic ablation or pharmacological inhibition of H3K9-methyl transferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: BED

Series

Accession:: GSE198421

ID:: 200198421

PubMed Full text in PMC Similar studies

Select item 2001146314.

Tumor-resident memory-like CD8 T cells represent an essential cellular target for cancer immunotherapy

(Submitter supplied) Persistent exposure to high levels of antigen results in the progressive exhaustion of T cells and has been thought to preclude the formation of memory. In contrast to the latter assumption, we show here that tumor-specific CD8 T cells residing in the tumor microenvironment include a Tcf1 expressing sub population that has key characteristics of central memory cells, lack an effector cell signature but display hallmarks of exhausted T cells, including the expression co-inhibitory receptors such as PD1. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
11 Samples

Download data: TXT

Series

Accession:: GSE114631

ID:: 200114631

PubMed Similar studies SRA Run Selector

Select item 2001229695.

Checkpoint blockade immunotherapy induces dynamic changes in PD-1-CD8+ tumor-infiltrating T cells

(Submitter supplied) An improved understanding of the anti-tumor CD8+ T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies. Here we examined the dynamics of the effector response of CD8+ tumor-infiltrating lymphocytes (TILs) after checkpoint blockade therapy. Bulk and single-cell RNA profiles of CD8+ TILs after combined Tim-3+PD-1 blockade in preclinical models revealed significant changes in the transcriptional profile of PD-1? TILs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL17021
28 Samples

Download data: TXT

Series

Accession:: GSE122969

ID:: 200122969

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001062686.

single-cell-RNA-sequencing and H3K9me3 occupancy of CD8+ T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
16 Samples

Download data: BED, H5

Series

Accession:: GSE106268

ID:: 200106268

PubMed Similar studies

Select item 2001062677.

H3K9me3 native ChIP-seq analysis of in vitro cultured wild-type CD8+ T cells

(Submitter supplied) H3K9me3 mark dynamic changes during CD8+-T cell differentiation in vitro

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BED

Series

Accession:: GSE106267

ID:: 200106267

PubMed Similar studies SRA Run Selector

Select item 2001062658.

H3K9me3 ChIP-seq analysis of in vitro cultured littermate and Suv39h1-KO CD8+ T cells

(Submitter supplied) H3K9me3 mark deposition by the histone methyltransferase Suv39h1 during CD8+-T cell differentiation in vitro

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BED

Series

Accession:: GSE106265

ID:: 200106265

PubMed Similar studies SRA Run Selector

Select item 2001062649.

single-cell-RNA-sequencing analysis of naive and Listeria monocytogenes-specific CD8+ T cells

(Submitter supplied) The histone methyltransferase Suv39h1 silences transcriptional programs during CD8+-T cell differentiation The study explores the role of gene silencing by Suv39h1, a histone methyltransferase, that plays a critical role in heterochromatin dynamics.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: H5

Series

Accession:: GSE106264

ID:: 200106264

PubMed Similar studies SRA Run Selector

Select item 20010516310.

Transcriptome analysis of naive and Listeria monocytogenes-specific CD8+ T cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17400
14 Samples

Download data: CEL

Series

Accession:: GSE105163

ID:: 200105163

Select item 20011138911.

Gene expression profiles of PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of FACS-sorted PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: TSV

Series

Accession:: GSE111389

ID:: 200111389

Select item 20014816212.

Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

(Submitter supplied) Although understanding of T-cell exhaustion is widely based on mouse models, its analysis in cancer patients could provide clues indicating tumor sensitivity to immune checkpoint blockade (ICB). Data suggests a role for costimulatory pathways, particularly CD28, in exhausted T-cell responsiveness to PD-1/PD-L1 blockade. Here, we used single-cell transcriptomic, phenotypic, and functional approaches to dissect the relation between CD8+ T-cell exhaustion, CD28 costimulation, and tumor specificity in head and neck, cervical, and ovarian cancers. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
4 Samples

Download data: TSV

Series

Accession:: GSE148162

ID:: 200148162

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010080913.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing

Platforms:: GPL13112 GPL21103
11 Samples

Download data: TXT

Series

Accession:: GSE100809

ID:: 200100809

PubMed Full text in PMC Similar studies

Select item 20010080814.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade [WES]

(Submitter supplied) Immune checkpoint blockade is able to achieve durable responses in a subset of patients, however we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4 and anti-PD-1 induced tumor rejection. To address these issues we utilized mass cytometry to comprehensively profile the effects of checkpoint blockade on tumor immune infiltrates in human melanoma and murine tumor models. These analyses reveal a spectrum of tumor infiltrating T cell populations that are highly similar between tumor models and indicate that checkpoint blockade targets only specific subsets of tumor infiltrating T cell populations. more...

Organism:: Mus musculus

Type:: Genome variation profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE100808

ID:: 200100808

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010080715.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: CSV

Series

Accession:: GSE100807

ID:: 200100807

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017127416.

Conditional deletion of Pdcd1 identifies the cell-intrinsic action of PD-1 on functional CD8 T cell subsets for anti-tumor efficacy

(Submitter supplied) PD-1 blockade has a profound effect on the ability of the immune system to eliminate tumors but many questions remain about the cell types involved and the underlying mechanisms of immune activation. To shed some light on this, the cellular and molecular events following inhibition of PD-1 signaling was investigated in the MC-38 colon carcinoma model using constitutive (PD-1 KO) and conditional (PD1cKO) PD-1 KO mice as well as in wild type mice treated with an anti-PD-1 antibody. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
46 Samples

Download data: TXT

Series

Accession:: GSE171274

ID:: 200171274

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010169017.

Sequencing of tumor associated (B16f10-OVA) mir-155 Wt or deficient CD4+ and CD8+ T cells

(Submitter supplied) Tumor associated CD4+ and CD8+ T cells were sorted from B16f10 OVA expressing tumors in miR-155 flox, miR-155 flox CD4Cre+, and miR-155 flox CD4Cre+ mice treated with immune checkpoint blocking (ICB) antibodies by flow sorting on CD45+CD3+CD4+ cells and CD45+ CD3+CD8+ cells. RNA was collected from these cells to perform RNA sequencing of total RNA.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: TXT

Series

Accession:: GSE101690

ID:: 200101690

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008426418.

Response to programmed cell death-1 blockade in a murine melanoma syngeneic model requires costimulation, CD4 and CD8 T-cells

(Submitter supplied) The programmed cell death protein 1 (PD-1) limits effector T-cell functions in peripheral tissues and its inhibition leads to clinical benefit in different cancers. To better understand how PD-1 blockade therapy modulates the tumor-host interactions, we evaluated three syngeneic murine tumor models, the BRAFV600E-driven YUMM1.1 and YUMM2.1 melanomas, and the carcinogen-induced murine colon adenocarcinoma MC38. more...