Similar studies for GEO DataSets (Select 200199818) - GEO DataSets

Select item 2001998181.

The ubiquitous human skin commensal Staphylococcus hominis protects against opportunistic pathogens

(Submitter supplied) Staphylococcus hominis is frequently isolated from human skin and we hypothesize that it may protect the cutaneous barrier from opportunistic pathogens. We determined that S. hominis makes six unique auto inducing peptide (AIP) signals that inhibit the major virulence factor accessory gene regulator (agr) quorum sensing system of Staphylococcus aureus. We solved and confirmed the structures of three novel AIP signals in conditioned media by mass spectrometry, then validated synthetic AIP activity against all S. more...

Organism:: Staphylococcus hominis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32101
6 Samples

Download data: TXT

Series

Accession:: GSE199818

ID:: 200199818

PubMed Full text in PMC Similar studies

Select item 2001248182.

RNA-Seq analysis of human keratinocytes stimulated with synthetic PSMα3

(Submitter supplied) To determine the genes that change mRNA transcript abundance in primary human keratinocytes treated by S. aureus phenol-soluble modulins (PSM), we stimulated keratinocytes for 24h with either DMSO(-) Ctl or synthetic PSMα3 (5μg/mL).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
2 Samples

Download data: XLSX

Series

Accession:: GSE124818

ID:: 200124818

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000529783.

Pharmacologic disruption of agr quorum sensing in Staphylococcus aureus promotes host defense against skin and soft tissue infections

(Submitter supplied) Drug discovery for novel anti-infectives is essential to meet the global health threat of antibiotic resistant bacterial infections, including those caused by Staphylococcus aureus1,2. Because ~90% of S. aureus infections involve skin and soft tissues (SSTIs)3,4, we hypothesized that developing anti-virulence therapeutics5,6 for SSTIs could minimize pressure on resistance development while sparing conventional antibiotics for control of systemic infections. more...

Organism:: Staphylococcus aureus subsp. aureus USA300; Staphylococcus aureus

Type:: Expression profiling by array

Platform:: GPL8069
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE52978

ID:: 200052978

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001818574.

Inactivation of the response regulator AgrA has a pleiotropic effect on biofilm formation, pathogenesis and stress response in Staphylococcus lugdunensis

(Submitter supplied) Exploration of the the transcriptomic consequences of the complete deletion of agrA gene in Staphylococcus lugdunensis. Overall, the ΔagrA deletion significantly affected the expression of 400 genes. Among them, 149 were upregulated and 251 were downregulated.

Organism:: Staphylococcus lugdunensis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29710
8 Samples

Download data: TAB

Series

Accession:: GSE181857

ID:: 200181857

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002070455.

The quorum-sensing agr system protects Staphylococcus aureus from oxidative stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Staphylococcus aureus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27158
18 Samples

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Series

Accession:: GSE207045

ID:: 200207045

PubMed Full text in PMC Similar studies

Select item 2002069166.

The quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (overnight growth)

(Submitter supplied) The agr quorum-sensing system clearly links Staphylococcus aureus metabolism to virulence, but little is known about how agr alters metabolism to affect cell survival during severe stress. Recently, we reported that agr activity increases survival of bacteria during treatment with lethal concentrations of H2O2, a crucial host defense against S. aureus. Here we report that protection by agr extends to growth resumption during the exit from stationary phase. more...