GEO DataSets

(Submitter supplied) RNAseq data profiling the artemisinin-sensitive P. falciparum piggyBac mutant of the KIC5 gene (PF3D7_1138700, Kelch13 Interacting Candidate 5).

Organism:

Plasmodium falciparum; Plasmodium falciparum NF54

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23997 GPL21298

20 Samples

Download data: XLSX

(Submitter supplied) RNAseq data profiling the artemisinin-sensitive P. falciparum piggyBac mutant of the PF3D7_1136600 gene (conserved Plasmodium gene, unknown function)

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26920

20 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Plasmodium falciparum

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL11248 GPL11250

101 Samples

Download data: GPR

(Submitter supplied) Artemisinin resistance in Plasmodium falciparum malaria has emerged in western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. Using DNA microarrays we identify key features of a transcriptional profile that are associated with the delayed parasite clearance phenotype. These include reduced expression of several basic metabolic and cellular pathways in the early stages, and increased expression of essentially all functionalities associated with protein metabolism in the later stages of P. more...

Organism:

Plasmodium falciparum

Type:

Genome variation profiling by array

Platform:

GPL11250

10 Samples

Download data: GPR

(Submitter supplied) Artemisinin resistance in Plasmodium falciparum malaria has emerged in western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. Using DNA microarrays we identify key features of a transcriptional profile that are associated with the delayed parasite clearance phenotype. These include reduced expression of several basic metabolic and cellular pathways in the early stages, and increased expression of essentially all functionalities associated with protein metabolism in the later stages of P. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL11248

91 Samples

Download data: GPR

(Submitter supplied) A testing association of parasite genotypes with clinical resistance phenotype. Submission of genotypes from all microarray genotyped samples

Organism:

Plasmodium falciparum

Type:

Genome variation profiling by genome tiling array

Platform:

GPL18484

516 Samples

Download data: FTR

(Submitter supplied) K13 mutations are causal for artemisinin resistance in Plasmodium falciparum human malaria. The objective of our study is to characterize gene expression signatures associated with K13 mutations by comparing transcriptional profiles and response to DHA of K13 mutant (C580Y, R539T) and isogenic wild-type lines that were generated by zinc finger nuclease (ZFN) based editing in a long-term adapted (Dd2) and a contemporary laboratory-adapted clinical isolate (Cam3.II).

Organism:

Plasmodium falciparum

Type:

Expression profiling by array

Platform:

GPL18893

156 Samples

Download data: GPR

(Submitter supplied) Purpose: this study is to analyze the change of overal transcriptome after three stress conditions in ring-stage Plasmodium falciparum before and after knockdown of PfGCN5 by TetR-DOZI system. Methods: In this study, the transcriptomes of a parasite line (TetR-PfGCN5::GFP) for knockdown (KD) of PfGCN5 by withdral of anhydrotetracycline (aTc) comparing to its control (TetR-PfGCN5::GFP with aTc) under three stress conditions [HS: heat shock, low-glucose starvation: L-Glu, and low dose of dihydroartemisinin (DHA) treatment] were analyzed at ring stage by RNAseq. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26920

22 Samples

Download data: XLSX

(Submitter supplied) Single-nucleotide variations (SNVs) in RNA, arising from co- and post-transcriptional phenomena including transcription errors and RNA-editing, are well studied in a range of organisms. In the malaria parasite Plasmodium falciparum, stage-specific and non-specific gene-expression variations accompany the parasite’s array of developmental and morphological phenotypes over the course of its complex life cycle. more...

Organism:

Plasmodium falciparum

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL26920

14 Samples

Download data: SF, TXT