Similar studies for GEO DataSets (Select 200244028) - GEO DataSets

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Items: 20

Select item 2002440281.

single cell RNA-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma

(Submitter supplied) We have observed that the inactivation of SUV39H1 enhances 41BBz-CAR T cell long-term persistence, providing protection against tumor relapses and rechallenges in a xenograft mouse model of lung adenocarcinoma. The purpuse of this study is to investigate the transcriptomic differences of lung-infiltrating SUV39H1 knock-out versus mock 41BBz-CAR T cells by single cell RNA sequencing at days 8 and 28 after CAR T cell infusion.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: MTX, TSV

Series

Accession:: GSE244028

ID:: 200244028

PubMed Similar studies

Select item 2002440322.

SUV39H1 Ablation Enhances Long-Term CAR-T Function in Solid Tumors.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL33788
42 Samples

Download data: BED, CSV, MTX, RCC, TBI, TSV

Series

Accession:: GSE244032

ID:: 200244032

PubMed Similar studies

Select item 2002440303.

Nanostring analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) at different timepoint

(Submitter supplied) Failure of adoptive T cell therapies in cancer patients is linked to limited T cell expansion and persistence, even in memory-prone 41BB-(BBz)-based chimeric antigen receptor (CAR) T cells. In murine CD8+ T cells, SUV39H1 promotes differentiation and expansion of effector CD8+ T cells during acute infection by Listeria monocytogenes by silencing stemness and memory genes (Pace et al. Science, 2018). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL33788
24 Samples

Download data: RCC

Series

Accession:: GSE244030

ID:: 200244030

Select item 2002440294.

Single cell ATAC-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma

(Submitter supplied) We have observed that the inactivation of SUV39H1 enhances 41BBz-CAR T cell long-term persistence, providing protection against tumor relapses and rechallenges in a xenograft mouse model of lung adenocarcinoma. The purpuse of this study was to profile chromatin accessibility of SUV39H1-deficient compared to mock 41BBz-CAR T cells by single-cell assay for transposase accessible chromatin (scATAC-seq) on FACS-sorted T cells eight days after CAR T cell infusion into the mice.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: BED, CSV, MTX, TBI, TSV

Series

Accession:: GSE244029

ID:: 200244029

PubMed Similar studies

Select item 2002469605.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [scRNA/CITE-seq]

(Submitter supplied) Single cell gene expression profile of WT and SUV39H1-edited CAR T cells at pre-infusion (Day 0), day 9 and day 16 post infusion in tumor (NALM6) bearing NSG mice

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL24676
48 Samples

Download data: RDS

Series

Accession:: GSE246960

ID:: 200246960

PubMed Full text in PMC Similar studies

Select item 2002451876.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
64 Samples

Download data

Series

Accession:: GSE245187

ID:: 200245187

PubMed Full text in PMC Similar studies

Select item 2002451867.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [ATAC-Seq]

(Submitter supplied) Comparing genome accessibility profiles (ATACseq) of WT and SUV39H1-edited CAR T cells

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: TXT

Series

Accession:: GSE245186

ID:: 200245186

PubMed Full text in PMC Similar studies

Select item 2002451848.

Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function [RNA-Seq]

(Submitter supplied) Comparing transcriptional profiles (RNAseq) of WT and SUV39H1-edited CAR T cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: TXT

Series

Accession:: GSE245184

ID:: 200245184

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001062689.

single-cell-RNA-sequencing and H3K9me3 occupancy of CD8+ T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
16 Samples

Download data: BED, H5

Series

Accession:: GSE106268

ID:: 200106268

PubMed Similar studies

Select item 20010626710.

H3K9me3 native ChIP-seq analysis of in vitro cultured wild-type CD8+ T cells

(Submitter supplied) H3K9me3 mark dynamic changes during CD8+-T cell differentiation in vitro

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BED

Series

Accession:: GSE106267

ID:: 200106267

PubMed Similar studies SRA Run Selector

Select item 20010626511.

H3K9me3 ChIP-seq analysis of in vitro cultured littermate and Suv39h1-KO CD8+ T cells

(Submitter supplied) H3K9me3 mark deposition by the histone methyltransferase Suv39h1 during CD8+-T cell differentiation in vitro

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BED

Series

Accession:: GSE106265

ID:: 200106265

PubMed Similar studies SRA Run Selector

Select item 20010626412.

single-cell-RNA-sequencing analysis of naive and Listeria monocytogenes-specific CD8+ T cells

(Submitter supplied) The histone methyltransferase Suv39h1 silences transcriptional programs during CD8+-T cell differentiation The study explores the role of gene silencing by Suv39h1, a histone methyltransferase, that plays a critical role in heterochromatin dynamics.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: H5

Series

Accession:: GSE106264

ID:: 200106264

PubMed Similar studies SRA Run Selector

Select item 20010516313.

Transcriptome analysis of naive and Listeria monocytogenes-specific CD8+ T cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17400
14 Samples

Download data: CEL

Series

Accession:: GSE105163

ID:: 200105163

Select item 20019842314.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021
21 Samples

Download data: BED, TAR

Series

Accession:: GSE198423

ID:: 200198423

PubMed Full text in PMC Similar studies

Select item 20019842215.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas [scRNA-seq]

(Submitter supplied) Purpose: We show that genetic ablation or pharmacological inhibition of H3K9-methyl transferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: RDS, TAR

Series

Accession:: GSE198422

ID:: 200198422

PubMed Full text in PMC Similar studies

Select item 20019842116.

CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas [ATAC-seq]

(Submitter supplied) Purpose: We show that genetic ablation or pharmacological inhibition of H3K9-methyl transferase Suv39h1 delays tumor growth and potentiates tumor rejection by anti-PD-1.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: BED

Series

Accession:: GSE198421

ID:: 200198421

PubMed Full text in PMC Similar studies

Select item 20018414017.

Oct4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 lysine methylation to pluripotency

(Submitter supplied) We report RNA-seq expression data of different cell lines of mouse embryonic stem cells in self-renewal conditions and upon the inactivation of Oct4 or Esrrb. ChIP-seq of H3K9me3 and ATAC-seq data of wild-type and Suv39h1as deleted cells are also provided.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
28 Samples

Download data: BW, TXT

Series

Accession:: GSE184140

ID:: 200184140

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013537918.

Development of gene expression signatures of B7-H3 CAR-T cells for treatment of SAHA

(Submitter supplied) We have employed mRNA microarray expression profiling as a discovery platform to identify genes with the potential to explain how small dose SAHA promoted the cell toxicity of B7-H3 CAR-T cells. B7-H3 CAR-T cells were treated by 0.5μM SAHA for 5 days, and with control samples.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
6 Samples

Download data: TXT

Series

Accession:: GSE135379

ID:: 200135379

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012373919.

Nr4a transcription factors limit CAR-T cell function in solid tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
138 Samples

Download data

Series

Accession:: GSE123739

ID:: 200123739

PubMed Full text in PMC Similar studies

Select item 20012373820.

Nr4a transcription factors limit CAR-T cell function in solid tumors [RNA-Seq]

(Submitter supplied) Chromatin accessibility with ATAC-seq and gene expression with RNA-seq for CD8 T cells expressing chimeric antigen receptors in solid tumors or after in vitro culture.