Similar studies for GEO DataSets (Select 200261345) - GEO DataSets

Select item 2002613451.

Spatially preserved multi-region transcriptomic subtyping and biomarkers of outcome with chemoimmunotherapy in extensive-stage small cell lung cancer [CANTABRICO_DSP cohort]

(Submitter supplied) Transcriptomic subtyping holds promise for personalized therapy in extensive stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers associated with long-term chemoimmunotherapy benefit in human ES-SCLC. Our work highlights that high intratumoral heterogeneity, lack of consistent association with outcome, and unclear subtype-specific target expression are major challenges for SCLC subtype-based precision oncology. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30173
121 Samples

Download data: DCC, PKC, PNG, XLSX

Series

Accession:: GSE261345

ID:: 200261345

PubMed Similar studies

Select item 2002613482.

Spatially preserved multi-region transcriptomic subtyping and biomarkers of outcome with chemoimmunotherapy in extensive-stage small cell lung cancer [IMfirst_DSP cohort]

(Submitter supplied) Transcriptomic subtyping holds promise for personalized therapy in extensive stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers associated with long-term chemoimmunotherapy benefit in human ES-SCLC. Our work highlights that high intratumoral heterogeneity, lack of consistent association with outcome, and unclear subtype-specific target expression are major challenges for SCLC subtype-based precision oncology. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30173
175 Samples

Download data: DCC, PKC, PNG, XLSX

Series

Accession:: GSE261348

ID:: 200261348

PubMed Similar studies

Select item 2002101143.

BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21290 GPL20301
71 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE210114

ID:: 200210114

PubMed Full text in PMC Similar studies

Select item 2002101134.

BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

(Submitter supplied) Small cell lung cancer can be divided into several molecular subtypes based on the expression of four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1). These master factors have not been directly druggable, and we hypothesized that targeting their transcriptional coactivator(s) could provide an alternative approach. Here, we identify that BET bromodomain proteins physically interact with NEUROD1 and function as transcriptional coactivators. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21290
14 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE210113

ID:: 200210113

PubMed Full text in PMC Similar studies

Select item 2002101105.

BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

(Submitter supplied) Small cell lung cancer can be divided into several molecular subtypes based on the expression of four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1). These master factors have not been directly druggable, and we hypothesized that targeting their transcriptional coactivator(s) could provide an alternative approach. Here, we identify that BET bromodomain proteins physically interact with NEUROD1 and function as its transcriptional coactivators. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: TXT

Series

Accession:: GSE210110

ID:: 200210110

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002101046.

BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

(Submitter supplied) Small cell lung cancer can be divided into several molecular subtypes based on the expression of four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1). These master factors have not been directly druggable, and we hypothesized that targeting their transcriptional coactivator(s) could provide an alternative approach. Here, we identify that BET bromodomain proteins physically interact with NEUROD1 and function as transcriptional coactivators. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
9 Samples

Download data: TXT

Series

Accession:: GSE210104

ID:: 200210104

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002101017.

BET inhibitors target the SCLC-N subtype of small-cell lung cancer by blocking NEUROD1 transactivation

(Submitter supplied) Small cell lung cancer can be divided into several molecular subtypes based on the expression of four master transcription factors (ASCL1, NEUROD1, POU2F3, and YAP1). These master factors have not been directly druggable, and we hypothesized that targeting their transcriptional coactivator(s) could provide an alternative approach. Here, we identify that BET bromodomain proteins physically interact with NEUROD1 and function as transcriptional coactivators. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
36 Samples

Download data: TXT

Series

Accession:: GSE210101

ID:: 200210101

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001644048.

Single-cell RNA Sequencing reveals functional difference of ASCL1-expressing and NEUROD1-expressing SCLC cells

(Submitter supplied) Small cell lung cancer (SCLC) is a particularly aggressive, lethal and widely metastatic lung cancer. Surgical specimens of SCLC are rare and difficult to obtain due to their early metastasis. In this study, we generated single cell lung suspensions of SCLC tissues. ScRNA-seq was performed on CD45 and CD31 negative live cells sorted by FACS. Purified cells were clustered to evaluate the cancer cell sub-clusters.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: H5

Series

Accession:: GSE164404

ID:: 200164404

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001641459.

PAX5 controls lineage transitions between neuroendocrine and non-neuroendocrine states during carcinoma progression

(Submitter supplied) Single cell lung suspensions of SCLC tissues were generated. scRNA-seq was performed on CD45 and CD31 negative live cells sorted by FACS. Purified cells were clustered to evaluate the cancer cell sub-clusters.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: H5

Series

Accession:: GSE164145

ID:: 200164145

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018518710.

Inhibition of Karyopherin β1-mediated nuclear import of lineage-defining TFs in small cell lung cancer

(Submitter supplied) Extensive genomic studies support the classification of small cell lung cancer (SCLC) into subtypes based on expression of lineage-defining transcription factors including ASCL1 and NEUROD1, which together account for ~80% of this disease. ASCL1 and NEUROD1 activate SCLC oncogene expression and drive distinct transcriptional programs. ASCL1 is also required for tumorigenesis in SCLC mouse models, and both ASCL1 and NEUROD1 maintain the in vitro growth and oncogenic properties of ASCL1+ or NEUROD1+ SCLC cell lines. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21626 GPL21697
32 Samples

Download data: TXT

Series

Accession:: GSE185187

ID:: 200185187

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014502811.

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer

(Submitter supplied) The bromodomain and extra-terminal (BET) protein BRD4 functions as a transcriptional activator and is a therapeutic target for different human cancers. Here, we report a critical link between Polycomb repressive deubiquitinase-BAP1 (PR-DUB) complex and BRD4, which is bridged by the physical interaction between additional sex combs-like protein 3 (ASXL3) in small cell lung cancer (SCLC). We further showed that ASXL3 functions as an adaptor protein, which directly interacts with BRD4-extra-terminal (ET) domain via a novel BRD4 binding motif (BBM), and maintains chromatin occupancy of BRD4 at active enhancers. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
37 Samples

Download data: BW

Series

Accession:: GSE145028

ID:: 200145028

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014918012.

MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate [SuperSeries]

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL24247 GPL17021
38 Samples

Download data: MTX, TSV

Series

Accession:: GSE149180

ID:: 200149180

PubMed Full text in PMC Similar studies

Select item 20010616413.

miRNAs regulated by TTF-1 in small cell lung cancer cell lines

(Submitter supplied) To determine miRNAs regulated by TTF-1 in SCLC cell lines, miRNA array analyses were carried out in NCI-H209 cells following TTF-1 knockdown

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
2 Samples

Download data: CEL

Series

Accession:: GSE106164

ID:: 200106164

Select item 20010609114.

Genes regulated by TTF-1 in small cell lung cancer cell lines

(Submitter supplied) To investigate genes possibly regulated by TTF-1 in small cell lung cancer cell lines, we compared gene expression profiles of NCI-H209 and Lu139 cell lines electroporated with control and TTF-1 siRNAs.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE106091

ID:: 200106091

Select item 20007665215.

Silencing of ASCL1 in U87MG glioma cells

(Submitter supplied) ASCL1 is known to act as transcriptional activator of notch signaling pathway. We have found that ASCL1 is over expressed in secondary glioblastoma. In order to delineate its functional role in gliomagensis we have used gene silencing approach to identify genes differentially regulated upon ASCL1 down regulation in U87MG glioma cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16356
6 Samples

Download data: CEL

Series

Accession:: GSE76652

ID:: 200076652

Select item 20015190416.

RNAseq analysis of small cell lung cancer (SCLC) cell lines

(Submitter supplied) Small cell lungcancer (SCLC) is an aggressive malignancy with dismal clinical outcomes, due inpart to the scarcity of post-relapse tissue samples. To understand more of transcriptional changes associated with treatment resistance, we performed RNAseq analysis of 61 SCLC cell lines.