GEO DataSets

Analysis of livers and quadriceps muscles of Kruppel-like factor 15 (KLF15) null mutants after an overnight fast. KLF15 nulls develop hypoglycemia after fasting. Gluconeogenesis (GLC) is essential for preventing hypoglycemia during fasting. Results provide insight into the role of KLF15 in GLC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL8321

Series:

GSE7137

16 Samples

Download data: CEL, EXP

(Submitter supplied) We used microarray analysis to identify differences in gene expression levels, in liver and in quadriceps skeletal muscle, between 18h (overnight) fasted WT control and Kruppel-like factor 15 (KLF15)-null mice. Keywords: comparative expression analysis, fasted state

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2687

Platform:

GPL8321

16 Samples

Download data: CEL, EXP

(Submitter supplied) Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood. Alanine transaminases (ALT1 and ALT2) catalyze the interconversion of alanine and pyruvate, which is required for gluconeogenesis from alanine. Hepatocyte-specific knockout of Gpt2 attenuated incorporation of 13C-alanine into newly synthesized glucose by hepatocytes. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

24 Samples

Download data: TXT

(Submitter supplied) We used microarrays to investigate gene expression patterns in liver of hepatocyte-specific Lkb1 deficiency

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) We characterize the phenotype of mice in which the deletion of Lkb1 has been targeted in the liver. Lack of Lkb1 in the liver results in bile duct paucity leading to cholestasis. This phenotype is similar to that obtained upon inactivation of Notch signaling in the liver. We test the hypothesis of a functional overlap between the Lkb1 and Notch pathways by gene expression profiling of livers deficent in Lkb1 or in the Notch mediator RbpJκ. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17791

12 Samples

Download data: CEL