GEO DataSets

Analysis of ileum from human enterocyte-associated E-cadherin receptor-expressing, germ-free transgenic mice (Fabpi-hEcad) colonized with wildtype L. monocytogenes or mutant strains with inlA, inlB, hly deletions. Results provide insight into host response to invasive foodborne enteropathogens.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 9 infection sets

Platform:

GPL81

Series:

GSE7013

20 Samples

Download data: CEL, EXP

(Submitter supplied) Ileal profiles from gnotobiotic mice mono-associated with Listeria species or B. thetaiotaomicron. Samples were derived from 72h colonizations of Fabpi-hEcad transgenic B6 mice fed a standard-chow polysaccharide rich (PR) diet. Keywords: Germ-free vs. Mono-associations

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3506

Platform:

GPL81

20 Samples

Download data: CEL, EXP

(Submitter supplied) We report the single celll RNA sequencing data of CD11chiMHChiSIRPa+ Peyer's patch cells

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

1 Sample

Download data: MTX, TSV

(Submitter supplied) CD11chi cells can be subdivided into six different cell subsets:plasmacytoid DCs (pDCs), CD8a+ DCs, CD11b+ DCs, double-negative (DN) DCs, LysoDCs, and LysoMacs. Among these, LysoDC (CD4–) and LysoMacs (CD4+) are classified as CD11chiMHC class II+BST2intSIRPαhi lysozyme+ cells, depending on whether they express CD4. Here, we determine that C5aR expressed in LysoDC and LysoMacs. We used microarrays to determine the lineage of C5aR+ LysoDC and C5aR- LysoDC.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

9 Samples

Download data: CEL

(Submitter supplied) C5a–C5aR signaling results in an intracellular calcium influx through activation of the coupled G-protein, which triggers ROS generation in APCs. To investigate the effect of C5a–C5aR signaling on cell function, we analyzed the gene expression profile of rC5a-treated C5aR+ LysoDCs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21163

6 Samples

Download data: TXT

(Submitter supplied) In a time course study, we characterized global gene expression profile of B. melitensis-infected bovine Peyer patches in the first 4 h p.i. Microarray analysis revealed that 2,916 bovine genes were detected as differentially expressed (z-score p < 0.025) in loops inoculated with virulent B. melitensis 16M compared with controls between 15 min and 4 h post-infection. From these genes, 2,286 (78%) were up- and 630 (22%) were down-regulated. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2853

20 Samples

Download data: GPR

(Submitter supplied) M cells are the main site of bacterial translocation in the intestine. We used the in vitro M cell model to study the effect of the commensal bacteria; Lactobacillus salivarius, Eschericha coli and Bacteroides fragilis, on M cell gene expression. Bacterial translocation across the gut mucosa has traditionally been based on the detection of commensals in the mesenteric lymph node. Differential rates of commensal translocation have been reported in vivo, however fewer studies have examined translocation of commensals at the level of the gut epithelial M cell. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

15 Samples

Download data: CEL, CHP

(Submitter supplied) Laser captured cecal epithelium from gnotobiotic mice colonized with B. thetaiotaomicron or B. longum (mono-association) or B. thetaiotaomicron bi-association with B. longum. Samples were derived from 10d colonizations of NMRI mice fed a standard-chow polysaccharide rich (PR) diet. Keywords: Germ-free vs. Mono-associations or Bi-association, in vivo

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1261 GPL1981

16 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Bifidobacterium longum; Bacteroides thetaiotaomicron

Type:

Expression profiling by array

Platform:

GPL1821

34 Samples

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(Submitter supplied) Genome wide transcriptional comparison of B. thetaiotaomicron mono-association vs. B. thetaiotaomicron bi-association with B.animalis or L. casei. Cecal populations from 20d colonizations with B6 gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Keywords: Mono-association vs. Bi-association, in vivo

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array

Platform:

GPL1821

9 Samples

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(Submitter supplied) Genome wide transcriptional comparison of B. thetaiotaomicron mono-association vs. B. thetaiotaomicron bi-association with B. longum. Cecal populations from 10d colonizations with b6 gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Keywords: Mono-association vs. Bi-association, in vivo

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array

Platform:

GPL1821

10 Samples

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(Submitter supplied) Genome wide transcriptional comparison of B. thetaiotaomicron or B. longum mono-association vs. B. thetaiotaomicron bi-association with B. longum. Cecal populations from 10d colonizations with NMRI gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Keywords: Mono-association vs. Bi-association, in vivo

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array

Platform:

GPL1821

15 Samples

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(Submitter supplied) The large-scale application of genomic and metagenomic sequencing technologies has yielded a number of insights about the metabolic potential of symbiotic human gut microbes. Bacteria that colonize the mucosal layer that overlies the gut epithelium have access to highly-sulfated polysaccharides (i.e., mucin oligosaccharides and glycosaminoglycans), which they could potentially forage as nutrient sources. more...

Organism:

Lactobacillus delbrueckii; Bacteroides thetaiotaomicron; Streptococcus thermophilus; Lacticaseibacillus casei; Bifidobacterium animalis; Agathobacter rectalis; Bifidobacterium longum

Type:

Expression profiling by array

Platform:

GPL11169

12 Samples

Download data: CEL

(Submitter supplied) Background: Inflammatory bowel diseases (IBD) may be caused in part by aberrant immune responses to commensal intestinal microbes including Bacteroides thetaiotaomicron (B.theta). Healthy, germ-free HLA-B27 transgenic (Tg) rats develop chronic colitis when colonized with complex gut commensal bacteria whereas non-transgenic (nTg) rats remain disease-free. However, the role of B.theta, a well-characterized anaerobic commensal bacterium, in causing disease in Tg rats is unknown nor is much known about how microbes respond to host inflammation. more...

Organism:

Bacteroides thetaiotaomicron; Lachnospira eligens; Phocaeicola vulgatus; Methanobrevibacter smithii; Parabacteroides distasonis; Agathobacter rectalis

Type:

Expression profiling by array

Platform:

GPL7006

6 Samples

Download data: CEL

(Submitter supplied) Listeriosis is an infectious disease caused by the intracellular bacterium Listeria monocytogenes. To control the infection effectively, the host immune response is directed by intercellular signalling molecules called cytokines that are produced by immune cells following sensing of the bacteria. In this study we used gene expression analysis to examine complex immune signalling networks in the blood and tissues of mice infected with L. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

192 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array

Platform:

GPL1821

28 Samples

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(Submitter supplied) Gnotobiotic NMRI mice were colonized at birth with B. thetaiotaomicron. Mice were sacrificed at P17 or P30, cecal contents were harvested and used for transcriptional profiling. Keywords: developmental timepoints, in vivo

Organism:

Bifidobacterium longum; Bacteroides thetaiotaomicron

Type:

Expression profiling by array

Platform:

GPL1821

12 Samples

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(Submitter supplied) Genome wide trascriptional comparison of B. thetaiotaomicron wild-type vs. an isogenic mutant (BT3172::pGERM). Cecal populations of wt or BT3172::pGERM monoassociated 10d with NMRI gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Keywords: Wild-type versus Knockout, in vivo

Organism:

Bifidobacterium longum; Bacteroides thetaiotaomicron

Type:

Expression profiling by array

Platform:

GPL1821

23 Samples

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(Submitter supplied) Transcriptional profiling of Bacteroides thetaiotaomicron was performed on samples taken from (i) chemostat cultures (in vitro) and (ii) from the ceca of gnotobiotic monoassociated NMRI mice (in vivo). In vitro profiles were obtained from biological duplicate cultures taken at five timepoints from log to stationary phase in three types of media: (i) minimal media glucose (MM-G), (ii) minimal media maltotriose (MM-M), and (iii) rich media (TYG). more...

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array

Dataset:

GDS1849

Platform:

GPL1821

42 Samples

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Analysis of Bacteroides thetaiotaomicron (BT) from the ceca of mice on polysaccharide or simple sugar diets. BT is involved in the breakdown of plant polysaccharides. BT-colonized mice is a human gut ecosystem model. Results identify genes that may endow flexibility in adapting to dietary changes.

Organism:

Bacteroides thetaiotaomicron; Bifidobacterium longum

Type:

Expression profiling by array, count, 5 growth protocol, 2 protocol, 16 time sets

Platform:

GPL1821

Series:

GSE2231

42 Samples

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