GEO DataSets

Analysis of various types of liposarcomas treated with doxorubicin in vitro. While doxorubicin is an established chemotherapeutic for treating liposarcomas, the response to this drug is low. Results provide insight into the molecular basis of the resistance of liposarcomas to doxorubicin.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 development stage, 6 disease state, 19 specimen sets

Platform:

GPL96

Series:

GSE12972

38 Samples

Download data: CEL, CHP

(Submitter supplied) Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment. Cells of 19 primary human liposarcoma were harvested intraoperatively and brought into cell culture. Cells were incubated with doxorubicin for 24 h, RNA was isolated and differential gene expression was analysed by the microarray technique. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3514

Platform:

GPL96

38 Samples

Download data: CEL, CHP

(Submitter supplied) An integrated profiling approach was performed to define molecular alterations associated to the aggressive behavior of retroperitoneal dedifferentiated liposarcoma. In particular, matched well and dedifferentiated components as well as normal adipose tissues, obtained from the same tumor sites, were comparatively investigated to higlight differences in gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

45 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16851

115 Samples

Download data: TXT

(Submitter supplied) Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into the biology of liposarcoma tumorigenesis is needed to devise novel therapeutic approaches. MicroRNAs (miRNAs) have been associated with carcinogenesis in many tumors and may function as tumor suppressor or oncogene. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16851

58 Samples

Download data: TXT

(Submitter supplied) Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into the biology of liposarcoma tumorigenesis is needed to devise novel therapeutic approaches. MicroRNAs (miRNAs) have been associated with carcinogenesis in many tumors and may function as tumor suppressor or oncogene. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL16851

57 Samples

Download data: TXT

(Submitter supplied) HT1080 fibrosarcoma cells were treated with cytostatic drugs and analysed on Affymetrix microarray to identify genes and pathways regulated by these compounds. The array images were processed using Affymetrix MAS 5.0 software. and normalized by global scaling or scaled to a polyA+ spike mask Keywords = Cytostatic drugs Keywords = Actinomycin D Keywords = Doxorubicin Keywords = Vincristine Keywords = apoptosis Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2007

Platform:

GPL96

7 Samples

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Analysis of fibrosarcoma HT1080 cells following exposure to the cytostatic chemotherapeutic agents actinomycin D or vincristine for 24 hours, or doxorubicin for 6 and 24 hours. Results provide insight into the molecular mechanisms underlying the cell death in response to cytotoxic therapies.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 3 time sets

Platform:

GPL96

Series:

GSE2238

5 Samples

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(Submitter supplied) Liposarcoma is the most common soft tissue sarcoma, accounting for about 20% of cases. Liposarcoma is classified into 5 histologic subtypes that fall into 3 biological groups characterized by specific genetic alterations. To identify genes that contribute to liposarcomagenesis and to better predict outcome for patients with the disease, we undertook expression profiling of liposarcoma. U133A expression profiling was performed on 140 primary liposarcoma samples, which were randomly split into training set (n=95) and test set (n=45). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

140 Samples

Download data: CEL

(Submitter supplied) Recent studies have identified clinical subtypes of breast tumors that arise from different cell types and have different outcomes in response to chemotherapy. Tumors derived from basal epithelium have a poorer prognosis than tumors derived from luminal epithelium. To gain insight into differences underlying this disparity, we treated cell lines derived from basal epithelium (immortalized human mammary epithelial cells) and those derived from luminal epithelium (MCF-7 and ZR-75-1) with two chemotherapeutics commonly used in the treatment of breast cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS845 GDS846 GDS847 GDS848

Platform:

GPL550

75 Samples

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Analysis of the response of luminal epithelium derived breast cancer line ZR-75-1 to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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Analysis of the response of luminal epithelium derived breast cancer line MCF-7 to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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Analysis of the response of basal epithelium derived breast cancer line HME-CC to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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Analysis of the response of the basal epithelium derived breast cancer line ME16C to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

18 Samples

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(Submitter supplied) SK-MEL-2 cells treated with Ad-E2F-1 (MOI 2), Ad-E2F-1 (MOI 2)plus doxorubicin 0.1uM, or Ad-LacZ (MOI 2) plus doxorubicin 0.1uM Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2244

Platform:

GPL96

6 Samples

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Analysis of E2F-1 overexpressing SK-MEL-2 melanoma cells treated with the anti-cancer drug doxorubicin (dox). Results provide insight into the molecular mechanisms underlying the synergistic effect on melanoma cell apoptosis observed when E2F-1 overexpression is combined with dox treatment

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL96

Series:

GSE2715

6 Samples

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(Submitter supplied) Soft tissue sarcomas are a diverse set of fatal human tumors where few agents have demonstrable clinical efficacy, with the standard therapeutic combination of doxorubicin and ifosfamide showing only a 25-30% response rate in large multi-institutional trials. Although liposarcomas are the most common histological form of adult soft tissue sarcomas, research in this area is severely hampered by the lack of experimentally tractable in vitro model systems. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL570 GPL2005

39 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Tumor cell lines and drug-resistant counterparts. These data support the publication Gyorffy et al, Oncogene 2005 (July), Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. We contrasted the expression profiles of 13 different human tumor cell lines of gastric (EPG85-257), pancreatic (EPP85-181), colon (HT29) and breast (MCF7 and MDA-MB-231) origin and their counterparts resistant to the topoisomerase inhibitors daunorubicin, doxorubicin or mitoxantrone. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2705 GPL2706

13 Samples

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(Submitter supplied) Spotted cDNA Orestes clones. This set includes 4608 orestes in build 175 of the human UniGene database. Keywords = spotted, cDNA

Organism:

Homo sapiens

13 Series

1103 Samples

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(Submitter supplied) Spotted cDNA Orestes clones and PCR amplified fragments on glass. This set includes 664 orestes and 197 PCR amplified fragments based upon representative sequences in build 175 of the human UniGene database. Keywords = spotted Keywords = cDNA

Organism:

Homo sapiens

1 Series

118 Samples

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