GEO DataSets

Analysis of PBMCs from breast cancer patients, patients with benign breast abnormalities, healthy individuals, and patients with other types of cancer (GI, brain). These results, together with results from a murine breast cancer model, provide insight into developing a human breast tumor predictor.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 6 disease state, 2 protocol sets

Platform:

GPL570

Series:

GSE27567

162 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3952 GDS3953

Platforms:

GPL570 GPL1261

255 Samples

Download data: CEL

(Submitter supplied) Female MMTV/c-MYC transgenic mice expressed the c-MYC proto-oncogene or a more stable point mutation variant (T58A) of the gene under the control of the hormone-responsive MMTV long terminal repeat (LTR) in an FVB/NJ background (Jackson Laboratories, Bar Harbor, ME). The hormones released during pregnancy and lactation have been shown to enhance expression of the oncogene. Thus, the mice were maintained in a continuous breeding program. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

93 Samples

Download data: CEL

(Submitter supplied) We analyzed gene expression in human peripheral blood mononuclear cells (PBMCs) from breast cancer patients, patients with benign breast abnormalities, healthy cancer-free individuals as well as patients with other types of cancer (gastrointestinal and brain cancers).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

162 Samples

Download data: CEL

Analysis of PBCs from FVB/NJ female, MMTV/c-MYC transgenics with advanced mammary tumors versus tumor-free controls matched for age and parity. These results, together with results from breast cancer patients, provide a foundation for developing a human breast tumor predictor.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 disease state, 2 protocol sets

Platform:

GPL1261

Series:

GSE27567

93 Samples

Download data: CEL

(Submitter supplied) Transcriptomic profiling of human breast tumors. Genomic and expression profiling using 38K BAC array-CGH and Illumina HT-12 beadchips were performed on 53 invasive breast tumors to assess the impact of gene dosage on gene expression patterns and the effect of other mechanisms on transcriptional levels. Array-CGH results was validated by FISH using tumors showing 8p11-p12 DNA amplification and expression profiling was confirmed using qPCR for 11 transcripts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

53 Samples

Download data: IDAT, TXT

(Submitter supplied) Genomic and expression profiling using 38K BAC array-CGH and Illumina HT-12 beadchips were performed on 97 diploid invasive breast tumors to assess the impact of gene dosage on gene expression patterns and the effect of other mechanisms on transcriptional levels. Patient stratification was performed according to axillary lymph node status (node-negative, pN0; node-positive, pN1) and overall survival (>8-year survivors; breast cancer-specific mortality within 8 years of diagnosis). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

97 Samples

Download data: CSV, IDAT, TXT

(Submitter supplied) Aberrant gene expression analysis between peripheral blood mononuclear cell (PBMC) samples from healthy individuals and patients with pancreatic carcinoma, gastric carcinoma and hepatocellular carcinoma (HCC) were identified using Affymetrix gene arrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4882

Platform:

GPL570

26 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells from hepatocellular carcinoma (HCC), pancreatic carcinoma, and gastric carcinoma patients. Results provide insight into a blood-based gene signature for detection of early-stage HCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state sets

Platform:

GPL570

Series:

GSE49515

26 Samples

Download data: CEL

(Submitter supplied) We used microarrays to compare gene expression profiles between mouse mammary tumors initiated by Myc to those that have escaped Myc oncogene dependence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

75 Samples

Download data: CEL

(Submitter supplied) Analysis of expression profile of peripheral blood from pancreatic ductal adenocarcinoma patients RNA expression profile of peripheral blood from pancreatic ductal adenocarcinoma patients

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

50 Samples

Download data: TXT

(Submitter supplied) The presence of some malignancies, such as cancer, impacts on peripheral blood mononuclear cells (PBMCs) gene expression profiling, suggesting the potential suitability of these genes as diagnostic and prognostic markers. The objective of this study was to identify new markers in peripheral blood that differentiate between PDAC patients and healthy controls as a means of facilitating fast detection of the disease.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

36 Samples

Download data: CEL

(Submitter supplied) MiRNA profiling from whole blood (EDTA) was used to identify a miRNA profile applicable for early stage breast cancer detection

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14132

105 Samples

Download data: TXT

(Submitter supplied) The combination of serum miRNAs and clinical factors could be a powerful classifier for evaluating axillary lymph node metastasis in breast cancer.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21263

958 Samples

Download data: TXT

(Submitter supplied) (Objectives) The goal of this study is to investigate paracrine effect of Peripheral Blood Mononuclear Cells (PBMCs) on Head and Neck cancer cell lines. (Method) Transcription profiles of PBMCs (control) and PBMCs co-cultured with Head and Neck cancer cell lines (treatment) were generated by deep sequencing, in triplicate for HN17 and duplicate for HN4, using Illumina HiSeq 4000. (Results and conclusion) Transcriptome analysis of PBMCs has shown the gene expression changed when co-cultured with HN cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

10 Samples

Download data: TXT

(Submitter supplied) Background. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogene induced tumorigenesis to overcome these biologic obstacles. We employed array CGH for 8 genetically-engineered mouse models of mammary cancer to identify loci that might harbor genes that enhance oncogene-induced tumorigenesis. more...

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL11288

45 Samples

Download data: TXT

(Submitter supplied) We performed affymetrix gene expression profiling on mammary tumors from eight well-characterized genetically engineered Mouse (GEM) models of human breast cancer. The gene expression data will be combined with the miRNA gene expression data from the corresponding mammary tumors and tissues for integrated miRNA and mRNA gene expression analysis, which are useful in improving the identification of miRNA targets from potential targets identified in silico.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4077

Platform:

GPL8321

46 Samples

Download data: CEL

Analysis eight well-characterized genetically engineered mouse (GEM) models of human breast cancer , including MMTV-H-Ras, -Her2/neu, -c-Myc, -PymT, -Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1(fl/fl);p53(+/-);MMTV-cre knock-out mice and the p53(fl/fl);MMTV-cre transplant model.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 9 genotype/variation, 3 strain, 2 tissue sets

Platform:

GPL8321

Series:

GSE23938

46 Samples

Download data: CEL

(Submitter supplied) Ndn is a candidate metastasis suppressor gene that has been reported to regulate transcription. We examined the changes in gene expression caused by the stable over-expression of allelic variants of Ndn, 50T or 50C, using lentiviral transduction in the mouse mammary tumor cell line Mvt-1.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

9 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL11383 GPL10481 GPL4092

71 Samples

Download data: TXT