GEO DataSets

Analysis of cultured cortical neurons treated with 1uM lactacystin for up to 48 hr. Lactacystin induces neuronal apoptosis. Results provide insight into molecular mechanisms underlying proteasomal inhibition-induced neuronal death.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL32

Series:

GSE22465

4 Samples

Download data: CEL

(Submitter supplied) Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse cortical neurons through the activation of caspase-3. Furthermore, proteasomal inhibitors are also reported to mediate deleterious alterations in cell cycle regulation, inflammatory processes and protein aggregation and trigger the cell death pathway. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4138 GDS4140

Platforms:

GPL81 GPL32

10 Samples

Download data: CEL

Analysis of cultured cortical neurons treated with 1uM lactacystin for up to 48 hr. Lactacystin induces neuronal apoptosis. Results provide insight into molecular mechanisms underlying proteasomal inhibition-induced neuronal death.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL81

Series:

GSE22465

6 Samples

Download data: CEL

(Submitter supplied) We used microarrays to examine gene expression levels from 131 unrelated CEPH-Utah grandparents with either DMSO or tunicamycin.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

262 Samples

Download data: CEL

(Submitter supplied) We used microarrays to examine gene expression levels from 95 unrelated CEPH-Utah individuals 0, 2 or 6 hours after treatment with 10Gy of ionizing radiation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

285 Samples

Download data: CEL