GEO DataSets

Analysis of lung from Insig1/2Δ/Δ animals. Insig1/2Δ/Δ animals exhibit lung inflammation and airspace remodeling associated with lipid accumulation in alveolar type 2 cells. Results provide insight into role of SREBP in regulation of lipid metabolism in lung.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE31797

6 Samples

Download data: CEL

(Submitter supplied) Background: Lung function is dependent upon the precise regulation of the synthesis, storage, and catabolism of tissue and alveolar lipids. Results: Activation of SREBP (Sterol Response Element Binding Protein) induced lipogenesis in alveolar epithelial cells, causing neutral lipid accumulation, lung inflammation, and tissue remodeling. Conclusions: The accumulation of neutral lipids in type II epithelial cells and alveolar macrophages caused lung inflammation, consistent with findings in lipid storage disorders. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4584

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) In this study, we studied the genomic responses of the Insig and Scap deletion from perinatal lung. Through comprehensive data analysis and integration, time dependent effects of epithelial SCAP/INSIG/SREBP deletion and defined SCAP/INSIG/SREBP-associated genes, bioprocesses and downstream pathways were identified.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

24 Samples

Download data: CEL

(Submitter supplied) Deletion of Stat3 induced genes influencing protein metabolism, transport, chemotaxis and apoptosis and decreased the expression of genes mediating lipid synthesis and metabolism. Srebf1 and 2, key regulators of fatty acid and steroid biosynthesis, were decreased in Stat3D/D mice. Stat3 influenced both pro- and anti-apoptotic pathways, regulating and maintaining the balance between a subset of pro- and anti-apoptotic genes that determine cell death or survival. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3106

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of type II alveolar cells lacking signal transducer and activator of transcription 3 (Stat3). STAT3 mediates gene expression in response to numerous growth factors and cytokines, playing an important role in many cellular processes. Results provide insight into the role of Stat3 in lung.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE6846

6 Samples

Download data: CEL

(Submitter supplied) We have previously demonstrated that deletion of the Cebpa gene in the developing fetal mouse lung caused death soon after birth from the failure of lung maturation. Many of the transcriptional pathways regulating morphogenesis of the fetal lung are induced postnatally and mediate repair of the injured lung. We hypothesized that C/EBPa plays a role in protection of the alveolar epithelium following hyperoxia injury of the mature lung. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

18 Samples

Download data: CEL