GEO DataSets

Analysis of livers from C57Bl/6J males fed an n-3 polyunsaturated fatty acid (n-3 PUFA) depleted diet for 3 months. Livers examined at the fed and fasting state. Result provide insight into the molecular mechanisms underlying the development of hepatic steatosis associated with n-3 PUFA depletion.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 2 stress sets

Platform:

GPL1261

Series:

GSE26986

4 Samples

Download data: CEL, CHP, XML

(Submitter supplied) In the present study, we investigated the consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice fed during three months with a diet presenting a high n-6/n-3 PUFA ratio to induce n-3 PUFA depletion. Microarray analyses were performed to identify the molecular targets involved in the development of hepatic steatosis associated with n-3 PUFA depletion.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4796

Platform:

GPL1261

4 Samples

Download data: CEL, CHP, XML

(Submitter supplied) in the present study, we evaluated whether microbiota modulation is able to restore hepatic steatosis induced by n-3 PUFA depletion in mice. For this purpose, mice were fed during three months with a n-3 PUFA-depleted diet (presenting a high n-6/n-3 PUFA ratio), and then supplemented with fructooligosaccharides (FOS, 0.25g/day/mice), a prebiotic, during the last ten days of the experiment (DEF/FOS). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL, CHP

(Submitter supplied) Nrg4 is a brown fat-enriched adipokine that binds to the liver and preserves metabolic homeostasis during chronic energy excess. Adipose tissue Nrg4 expression is reduced in mouse and human obesity. Nrg4 deficient mice develp more severe insulin resistance and hepatic fat accumulation upon high-fat diet feeding. We used microarrays to elucidate the metabolic pathways that are regulated by Nrg4 in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

6 Samples

Download data: CEL

(Submitter supplied) HDAC3 is a repressor of lipogenic gene expression whereas nuclear SREBP1c is a potent activiator that is controlled by SCAP. Since these factors share many lipogenic gene targets, we sought to determine their molecular crosstalk by ChIP-sequencing. We also tested whether ectopic expression of nSREBP1c interferes with HDAC3 binding near lipognic genes. To faciliate these pulldowns, we ectoipcally expressed HA-tagged nSREBP1c in mouse livers in vivo using AAV8 viruses and the thyroxine-binding globulin promoter for hepatocyte-specifc expression. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL13112

27 Samples

Download data: BED, BW, XLS