GEO DataSets

Analysis of lacrimal gland (LG) 7 days after greater superficial petrosal nerve sectioning. LG ipsilateral to the experimental side, sham operated and unoperated controls included. LG denervation results in severe dry eye like symptoms.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL85

Series:

GSE844

10 Samples

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(Submitter supplied) Control rat lacrimal gland samples representing a normal unoperated, a sham, and paired contralateral controls. Experimental LG samples representing paired and unpaired contralateral controls. Paired contralateral control LGs represent LG from the same animal, one side was operated and the other side unoperated. Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS508

Platform:

GPL85

10 Samples

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(Submitter supplied) Examine the effect of stimulation stress produced by chemical burn to the mice cornea in the lacrimal gland over a time course (0.5 - 360 hours) in comparison with the non-stimulated control animals. Using silver nitrate applicator (silver nitrate 37.5 mg and potassium nitrate 12.5 mg, Graham-Field,Inc.,) do two burns per eye, each with a separate applicator. For animals observed for more than 24 hours, eyes were then treated with gentamicin ointment to minimize infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS947 GDS948 GDS949

Platforms:

GPL1231 GPL1232 GPL1230

93 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 1 to 360 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 7 time sets

Platform:

GPL1232

Series:

GSE1393

29 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 24 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL1231

Series:

GSE1393

18 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 360 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 8 time sets

Platform:

GPL1230

Series:

GSE1393

46 Samples

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(Submitter supplied) Diagnosis of inflamed human orbit tissue with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of orbit biopsies to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), IgG4-associated disease, and subdivisions of NSOI. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

175 Samples

Download data: CEL

(Submitter supplied) The transcriptional expression analysis of 17.5, 19.5 days embryonic lacrimal gland (LG), adult lacrimal gland, lacrimal gland stem cells (LGSCs) P2 cultured for 5, 7, 10, 14 days and LGSCs P6, P10, P20 cultured for 7 days, respectively.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21273

24 Samples

Download data: TXT

(Submitter supplied) Background: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platforms:

GPL17586 GPL6244

8 Samples

Download data: CEL, TXT, XLS

(Submitter supplied) The lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights into the cell lineage relationships during tissue morphogenesis. However, little is known about the cell types composing the adult LG and their progenitors. Using scRNA-seq, we established the first comprehensive cell atlas of the adult mouse LG to investigate cell hierarchy, their secretory repertoire and sex differences.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21626 GPL24247

3 Samples

Download data: MTX, TSV

(Submitter supplied) As an element of the lacrimal apparatus, the lacrimal gland (LG) produces the aqueous part of the tear film, which protects the eye surface. Therefore, a defective LG can lead to serious eyesight impairment. Up to now, little is known about LG morphogenesis and subsequent maturation. In this study, we delineated elements of the cellular and molecular events involved in LG formation by using three epithelial markers, namely aSMA, Krt14 andKrt19. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

6 Samples

Download data: CEL, CHP