GEO DataSets

Comparison of mesangioblast clone lines D16 and D351 derived from E9.5 C57BL6 embryo dorsal aorta. Mesangioblast vessel-associated stem cells have possible use in therapy of primary myopathies.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line sets

Platform:

GPL81

Series:

GSE563

2 Samples

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(Submitter supplied) Mouse dorsal aorta from E9.5 mouse embryos (C57BL6) was grown as an explant culture as described elsewhere (De Angelis et al., 1999). After 5 days the explant was dissociated into a single cell suspension, and plated at limiting dilution on a feeder layer of Mitomycin C-treated primary embryonic mouse fibroblasts, in 96 multiwell plates in complete medium, RPMI 20% Fetal Calf Serum. After 1 week, mesangioblast clones appeared approximately 2-4% of the wells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS553

Platform:

GPL81

2 Samples

Download data

(Submitter supplied) Mouse dorsal aorta from E9.5 mouse embryos (C57BL6) was grown as an explant culture as described elsewhere (De Angelis et al., 1999). After 5 days the explant was dissociated into a single cell suspension, and plated at limiting dilution on a feeder layer of Mitomycin C-treated primary embryonic mouse fibroblasts, in 96 multiwell plates in complete medium, RPMI 20% Fetal Calf Serum. After 1 week, mesangioblast clones appeared approximately 2-4% of the wells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS555

Platform:

GPL83

2 Samples

Download data

(Submitter supplied) Mouse dorsal aorta from E9.5 mouse embryos (C57BL6) was grown as an explant culture as described elsewhere (De Angelis et al., 1999). After 5 days the explant was dissociated into a single cell suspension, and plated at limiting dilution on a feeder layer of Mitomycin C-treated primary embryonic mouse fibroblasts, in 96 multiwell plates in complete medium, RPMI 20% Fetal Calf Serum. After 1 week, mesangioblast clones appeared approximately 2-4% of the wells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS554

Platform:

GPL82

2 Samples

Download data

(Submitter supplied) Mouse dorsal aorta from E9.5 mouse embryos (C57BL6) was grown as an explant culture as described elsewhere (De Angelis et al., 1999). After 5 days the explant was dissociated into a single cell suspension, and plated at limiting dilution on a feeder layer of Mitomycin C-treated primary embryonic mouse fibroblasts, in 96 multiwell plates in complete medium, RPMI 20% Fetal Calf Serum. After 1 week, mesangioblast clones appeared approximately 2-4% of the wells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL82 GPL83 GPL81

6 Samples

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Comparison of mesangioblast clone lines D16 and D351 derived from E9.5 C57BL6 embryo dorsal aorta. Mesangioblast vessel-associated stem cells have possible use in therapy of primary myopathies.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line sets

Platform:

GPL83

Series:

GSE555

2 Samples

Download data

Comparison of mesangioblast clone lines D16 and D351 derived from E9.5 C57BL6 embryo dorsal aorta. Mesangioblast vessel-associated stem cells have possible use in therapy of primary myopathies.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line sets

Platform:

GPL82

Series:

GSE554

2 Samples

Download data

(Submitter supplied) In order to determine a mechanism through which TGF-b/Smad3 promote these effects, Affymetrix gene expression arrays were performed on primary rat SMCs infected with Smad3 and stimulated with TGF-b or infected with GFP alone. More than 200 genes were differentially expressed (>2.0 fold change, p<0.05) in TGF-b/Smad3 stimulated SMCs. We then performed GO term enrichment analysis using the DAVID bioinformatics database and found that TGF-b/Smad3 activated the expression of multiple genes related to either development or cell differentiation, several of which have been shown to be associated with multipotent stem or progenitor cells.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

6 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Resident vascular adventitial SCA1(+) progenitor (AdvSca1) cells are essential in vascular development and injury. However, the heterogeneity of AdvSca1 cells presents a unique challenge in understanding signaling pathways orchestrating their behavior in homeostasis and injury responses. Using smooth muscle cell (SMC) lineage tracing models, we identified a subpopulation of AdvSca1 cells (AdvSca1-SM) originating from mature SMCs that undergo reprogramming in situ and exhibit a multipotent phenotype. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL17021

28 Samples

Download data: TXT

(Submitter supplied) Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to define the set of genes that predict adipogenic potential in these cells. 374 genes/ESTs were identified whose expression in preadipocytes correlated with their ultimate ability to differentiate. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1219

Platform:

GPL81

28 Samples

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Expression profiling of brown preadipocytes derived from insulin receptor substrate (IRS) knockout animals.The IRS family of insulin signaling mediators is composed of IRS-1, IRS-2, IRS-3, and IRS-4. Results provide insight into the regulation of brown adipocyte differentiation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 genotype/variation sets

Platform:

GPL81

Series:

GSE2556

28 Samples

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(Submitter supplied) We took a broad approach to identify novel STAT3 regulated genes by examining changes in the genome-wide gene expression profile by microarray, using cells expressing constitutively-activated STAT3. Using computational analysis, we were able to define the gene expression profiles of cells containing activated STAT3 and identify candidate target genes with a wide range of biological functions. We demonstrated that STAT3 has an important role in regulating, both positively and negatively, a diverse array of cellular processes, including cell adhesion, cytoskeletal remodeling, nucleotide, lipid and protein metabolism, as well as signal transduction. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL