GEO DataSets

(Submitter supplied) Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively stable occurrence and progression of sharply demarcated lesions, usually on the trunk and extremities, which share a combination of trademark histological features, including tortuous and dilated dermal capillaries, loss of the epidermal granular layer, and accumulation of neutrophils beneath parakeratotic scale. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5392

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response between individual patients, and this may reflect heterogeneity of inflammatory networks driving the disease. In this study, whole-genome transcriptional profiling was used to characterize inflammatory and cytokine networks in 62 lesional skin samples obtained from patients with stable chronic plaque psoriasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4601

Platform:

GPL570

24 Samples

Download data: CEL

Analysis of 6 mm punch biopsies of lesional and non-lesional (uninvolved) skin from four chronic plaque psoriasis patients. Chronic plaque psoriasis is an inflammatory skin disease. Results provide insight into molecular mechanisms underlying this inflammatory skin disorder.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 individual, 2 tissue sets

Platform:

GPL570

Series:

GSE50790

8 Samples

Download data: CEL

Analysis of cultured keratinocytes treated with various cytokines: interleukin-4, -13, -17A, interferon-α, -γ, or TNF. Marked proliferation of keratinocytes characterizes the chronic inflammatory skin disease psoriasis. Results provide insight into cytokine activity signatures in keratinocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 7 agent, 4 individual sets

Platform:

GPL570

Series:

GSE36287

24 Samples

Download data: CEL