GEO DataSet Links for PMC (Select 3769504) - GEO DataSets

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Items: 2

Select item 2000484381.

Expression data from osteoblastic lineage cells isolated from normal and leukemic mice

(Submitter supplied) Multipotent stromal cells (MSC) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. During myeloproliferative neoplasm (MPN) development, MSCs are stimulated to overproduce functtionally altered OBCs, which accumulate in the BM cavity as myelofibrotic cells. These MPN-expanded OBCs, in turn, impair the maintenance of normal HSCs but not of leukemic stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5024
Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE48438

ID:: 200048438

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50242.

Induced myeloproliferative neoplasm effect on Scl-tTA::TRE-BCR/ABL double-transgenic model of chronic myeloid leukemia: osteoblastic lineage cells

Analysis of osteoblastic lineage cells (OBC) from Scl-tTA::TRE-BCR/ABL (BA) double-transgenics withdrawn from doxycycline at 5 weeks of age to induce myeloproliferative neoplasia (MPN). MPN development drives OBC expansion. Results provide insight into molecular features of MPN-expanded OBCs.