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Items: 4

1.

Transcriptional response to conditional over-expression of GDV1 in Plasmodium falciparum 3D7 wild type and F12 mutant parasites

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Plasmodium falciparum; Plasmodium falciparum 3D7
Type:
Expression profiling by array
Platform:
GPL15130
28 Samples
Download data: GPR
Series
Accession:
GSE95549
ID:
200095549
2.

Transgenic Plasmodium falciparum blood stage parasites F12/GDV1-GFP-DD: control (-Shield-1;F12/GDV1-GFP-DDOFF) vs GDV1-overexpressing (+Shield-1;F12/GDV1-GFP-DDON) parasites

(Submitter supplied) Transcriptional profiling of transgenic P. falciparum blood stage parasites expressing an ectopic copy of GDV1-GFP-DD (F12/GDV1-GFP-DD). The DD (FKBP destabilisation domain) allows for the conditional expression of fusion proteins: DD fusion proteins are rapidly degraded or stably expressed in absence or presence of the stabilising ligand Shield-1, respectively (Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. more...
Organism:
Plasmodium falciparum; Plasmodium falciparum 3D7
Type:
Expression profiling by array
Platform:
GPL15130
14 Samples
Download data: GPR
Series
Accession:
GSE95548
ID:
200095548
3.

Transgenic Plasmodium falciparum blood stage parasites 3D7/GDV1-GFP-DD: control (-Shield-1;3D7/GDV1-GFP-DDOFF) vs GDV1-overexpressing (+Shield-1;3D7/GDV1-GFP-DDON) parasites

(Submitter supplied) Transcriptional profiling of transgenic P. falciparum blood stage parasites expressing an ectopic copy of GDV1-GFP-DD (3D7/GDV1-GFP-DD). The DD (FKBP destabilisation domain) allows for the conditional expression of fusion proteins: DD fusion proteins are rapidly degraded or stably expressed in absence or presence of the stabilising ligand Shield-1, respectively (Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. more...
Organism:
Plasmodium falciparum 3D7; Plasmodium falciparum
Type:
Expression profiling by array
Platform:
GPL15130
14 Samples
Download data: GPR
Series
Accession:
GSE95547
ID:
200095547
4.

GDV1 triggers sexual conversion and differentiation in malaria parasites by antagonizing HP1-dependent gene silencing

(Submitter supplied) Malaria is caused by Plasmodium parasites that proliferate through iterative cycles of intra-erythrocytic replication. During each cycle a small number of parasites differentiate into gametocytes, the only forms able to infect the mosquito vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)-dependent silencing of ap2-g prevents sexual conversion and secures proliferation. more...
Organism:
Plasmodium falciparum
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL21298
14 Samples
Download data: BEDGRAPH
Series
Accession:
GSE94901
ID:
200094901
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