gds pubmed[Filter] - GEO DataSets - NCBI

Warning: The NCBI web site requires JavaScript to function. more...

Search results

Items: 1 to 20 of 193075

<< First< Prev

Page of 9654

Select item 2002828861.

Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status

(Submitter supplied) Temozolomide (TMZ) is an important first-line treatment for glioblastoma (GBM), but there are limitations to TMZ response in terms of durability and dependence on the promoter methylation status of the DNA repair gene O6-methylguanine DNA methyltransferase (MGMT). MGMT-promoter-hypermethylated (MGMT-M) GBMs are more sensitive to TMZ than MGMT-promoter-hypomethylated (MGMT-UM) GBMs. Moreover, TMZ resistance is inevitable even in TMZ-sensitive MGMT-M GBMs. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
16 Samples

Download data: IDAT, TXT

Series

Accession:: GSE282886

ID:: 200282886

Select item 2002759762.

Decreased estrogen level in ovariectomized mice causes an increase in oxidative stress in osteal macrophages leading to development of cellular senescence [scRNA-seq]

(Submitter supplied) Osteal macrophages were isolated from ovariectomized and control mice 4 weeks after surgery. Oeritoneal macrophages collected from ovariectomized mice exhibited gene signature of NADPH oxidase activation which is known as key modulator in aging and cell senescence.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE275976

ID:: 200275976

Select item 2002754593.

Decreased estrogen level in ovariectomized mice causes an increase in oxidative stress in osteal macrophages leading to development of cellular senescence

(Submitter supplied) Osteal macrophages were isolated from ovariectomized and control mice 4 weeks after surgery. Oeritoneal macrophages collected from ovariectomized mice exhibited gene signature of NADPH oxidase activation which is known as key modulator in aging and cell senescence.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: XLSX

Series

Accession:: GSE275459

ID:: 200275459

Select item 2002727434.

Cellular Communication Network Factor 3 contributes to the pathological process of rheumatoid arthritis via osteoclastgenesis in the joint.

(Submitter supplied) Cellular Communication Network Factor 3 (CCN3) is a secreted protein. It belongs to the CCN family of regulatory proteins, which play essential roles in various cellular processes. In this study, we investigated the functional characteristics of CCN3 in rheumatoid arthritis. We found CCN3 is involved in cellular senescence and osteoclastgenesis of macrophage in vitro. To understand this mechanism, CCN3 is were added to Macrophage and their responses were examined by bulk-RNA analysis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
3 Samples

Download data: XLSX

Series

Accession:: GSE272743

ID:: 200272743

Select item 2002716435.

Cellular Communication Network Factor 3 contributes to the pathological process of rheumatoid arthritis via promoting cell senescence in synovial cells

(Submitter supplied) Cellular Communication Network Factor 3 (CCN3) is a secreted protein. It belongs to the CCN family of regulatory proteins, which play essential roles in various cellular processes. In this study, we investigated the functional characteristics of CCN3 in rheumatoid arthritis. We found CCN3 is involved in cellular senescence and inflammation of fibroblast like synoviocyte (FLS) in vitro. To understand this mechanism, CCN3 is were added to FLS and their responses were examined by bulk-RNA analysis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE271643

ID:: 200271643

Select item 2002676456.

BCR, not TCR, repertoire diversity is associated with favorable COVID-19 [GEX]

(Submitter supplied) The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients. In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages. The study included three unvaccinated patients from each outcome category. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL28038 GPL24676
15 Samples

Download data: MTX, TSV

Series

Accession:: GSE267645

ID:: 200267645

Select item 2002676427.

BCR, not TCR, repertoire diversity is associated with favorable COVID-19 [BCR-Seq]

(Submitter supplied) The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients. In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages. The study included three unvaccinated patients from each outcome category. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL28038
15 Samples

Download data: CSV, TSV

Series

Accession:: GSE267642

ID:: 200267642

Select item 2002676398.

BCR, not TCR, repertoire diversity is associated with favorable COVID-19 [TCR-Seq]

(Submitter supplied) The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients. In this study, we used single-cell RNA sequencing to analyze the immune responses in recovered and deceased COVID-19 patients during moderate and critical stages. The study included three unvaccinated patients from each outcome category. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL28038 GPL24676
15 Samples

Download data: CSV

Series

Accession:: GSE267639

ID:: 200267639

Select item 2002825249.

Aberrant Neuronal Connectivity and Network Activity of Neurons Derived from Patients with Idiopathic Schizophrenia

(Submitter supplied) Schizophrenia (SCZ) is a psychiatric disorder with a strong genetic determinant. A major hypothesis to explain disease aetiology comprises synaptic dysfunction associated with excitatory-inhibitory imbalance of synaptic transmission, ultimately contributing to impaired network oscillation and cognitive deficits associated with the disease. Here, we studied the morphological and functional properties of a highly defined co-culture of GABAergic and glutamatergic neurons derived from induced pluripotent stem cells (iPSC) from patients with idiopathic SCZ. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
14 Samples

Download data: TXT

Series

Accession:: GSE282524

ID:: 200282524

Select item 20027241510.

New genomic resources inform transcriptomic responses to heavy metal toxins in the common Eastern bumble bee Bombus impatiens

(Submitter supplied) The common Eastern bumble bee Bombus impatiens is native to North America and is the main commercially reared pollinator in the Americas. There has been extensive research on this species related to its social biology, applied pollination, and genetics. The genome of this species was previously sequenced using short-read technology, but recent technological advances provide an opportunity for substantial improvements. more...

Organism:: Bombus impatiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34712
127 Samples

Download data: TSV

Series

Accession:: GSE272415

ID:: 200272415

Select item 20027178711.

The effect of ethanolamine phosphate phosphorylase knockout on hepatic gene expression

(Submitter supplied) Ethanolamine phosphate phospholyase (ETNPPL) is an enzyme that irreversibly degrades phospho-ethanolamine (p-ETN), an intermediate in the Kennedy pathway of phosphatidylethanolamine (PE) biosynthesis. PE is the second most abundant phospholipid in mammalian membranes. Disturbance of hepatic phospholipid homeostasis has been linked to the development of metabolic dysfunction-associated steatotic liver disease (MASLD). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: TXT

Series

Accession:: GSE271787

ID:: 200271787

Select item 20026275512.

Small intestine lamina propia iNKT cells in comparison to iNKT cells residing in lymphoid tissues

(Submitter supplied) Intestinal homeostasis is maintained through the combined functions of epithelial and immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the mechanisms by which immune cell populations regulate intestinal epithelial cell (IEC) homeostasis remain unclear. Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted Natural Killer T (NKT) cells as regulators of IEC biology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TXT

Series

Accession:: GSE262755

ID:: 200262755

Select item 20026275313.

Comparing the transcriptome of small intestinal epithelial cells in organoids after co-culture with NKT cells

(Submitter supplied) Intestinal homeostasis is maintained through the combined functions of epithelial and immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the mechanisms by which immune cell populations regulate intestinal epithelial cell (IEC) homeostasis remain unclear. Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted Natural Killer T (NKT) cells as regulators of IEC biology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE262753

ID:: 200262753

Select item 20026253214.

Comparing the transcriptome of small intestinal epithelial cells in CD1d-KO vs WT mice

(Submitter supplied) Intestinal homeostasis is maintained through the combined functions of epithelial and immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the mechanisms by which immune cell populations regulate intestinal epithelial cell (IEC) homeostasis remain unclear. Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted Natural Killer T (NKT) cells as regulators of IEC biology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE262532

ID:: 200262532

Select item 20026252615.

The effect of NKT cell activation on the transcriptome of intestinal epithelial cells

(Submitter supplied) Intestinal homeostasis is maintained through the combined functions of epithelial and immune cells that collaborate to preserve the integrity of the intestinal barrier. However, the mechanisms by which immune cell populations regulate intestinal epithelial cell (IEC) homeostasis remain unclear. Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted Natural Killer T (NKT) cells as regulators of IEC biology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: CSV

Series

Accession:: GSE262526

ID:: 200262526

Select item 20017307916.

Rising from the dead: A novel mechanism involving pyroptosis and pathologic neovascularization in retinopathy of prematurity

(Submitter supplied) To elucidate the changes in retinal angiogenesis, we performed single-cell RNA sequencing on OIR model isolated retinal cells.We found the specific expression of AIP1 gene in endothelial cells, which is related to the formation and development of retinal blood vessels, and the expression of AIP1 gene may play a protective role in the progression of disease.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30028
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE173079

ID:: 200173079

Select item 20028271617.

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development

(Submitter supplied) Involved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodies to enhance NK-cell function, but none use ion channel modulators, which are widely used in clinical practice to treat hypertension, diabetes, epilepsy, and other conditions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34290
16 Samples

Download data: XLSX

Series

Accession:: GSE282716

ID:: 200282716

Select item 20028219418.

Expression data from Methionine normal or deprived culture glioblastoma cell line U251

(Submitter supplied) Recent research highlights the significant impact of methionine metabolism on glioma progression. An increasing amount of compelling evidence bridges long non-coding RNAs to abnormal metabolism in gliomas. However, the specific role of long non-coding RNAs in methionine metabolism regulating glioma progression remains unclear. This study reveals that methionine deprivation inhibits the proliferation, migration, and invasion capabilities of gliomas. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL26963
6 Samples

Download data: TXT

Series

Accession:: GSE282194

ID:: 200282194

PubMed Analyze with GEO2R

Select item 20027815419.

Bulk and single cell RNA sequencing analyses of GBM Primary and Recurrent, early and late passages, DMSO / TMZ treatment.

(Submitter supplied) We used bulk RNA sequencing to analyze unsupervised clustering of early and late passages of four GBM PDXs. Single cell RNAseq data was used to study transcriptional profiles of DMSO and TMZ, Primary and Recurrent as well as early and late passages of GBM PDXs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL16791
37 Samples

Download data: CSV, RDS

Series

Accession:: GSE278154

ID:: 200278154

Select item 20027775720.

Cocaine-craving drives repressive epigenetic differential gene expression in ventral tegmental area dopamine neurons

(Submitter supplied) Dopamine (DA) signaling plays an essential role in reward valence attribution and in encoding the reinforcing properties of natural and artificial rewards. The adaptive responses from midbrain dopamine neurons to artificial rewards such as drugs of abuse are therefore important for understanding the development of substance use disorders. Drug-induced changes in gene expression are one such adaptation that can determine the activity of dopamine signaling in projection regions of the brain reward system. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
15 Samples

Download data: CSV, TXT

Series

Accession:: GSE277757

ID:: 200277757

<< First< Prev

Page of 9654

Supplemental Content

Filters: Manage Filters

Find related data

Search details

Important Links

Recent activity

Clear Turn Off Turn On

gds pubmed[Filter] (193075)
GEO DataSets

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets