txid105023[Organism] - GEO DataSets

(Submitter supplied) To explore the effects of the housing condition (group- or single-housing) on killifish, we performed RNA-seq analysis for the whole bodies of male and female juveniles, gonads of males and females from puberty to middle age, and livers of young and old males.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
86 Samples

Download data: TXT

Series

Accession:: GSE245481

ID:: 200245481

PubMed

Select item 2002454803.

Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish I.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
88 Samples

Download data: TXT

Series

Accession:: GSE245480

ID:: 200245480

PubMed

Select item 2002131544.

Single cell sequencing unravels the cellular diversity that shapes neuro- and gliogenesis in the fast aging killifish (N. furzeri) brain

(Submitter supplied) The African turquoise killifish combines a short lifespan with age-dependent loss of neuroregenerative capacity, making it a well-suited model for studying brain repair mechanisms in the context of aging. To investigate the extent of cellular diversity that shapes neuro- and gliogenesis, we performed single cell sequencing of the adult telencephalon. Our analysis identifies seventeen cell types including neuronal cells, and progenitors of glial and non-glial nature. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE213154

ID:: 200213154

Select item 2002553635.

Effect of ageing on gene expression in the African turquiose killifish retina

(Submitter supplied) The mammalian central nervous system (CNS) is susceptible to age-related pathologies, resulting in progressive, irreversible disease. Neurodegenerative eye conditions, like glaucoma and age-related macular degeneneration (AMD), are on the rise due to increased life expectancy. Despite this, there are currently no long-term therapies to prevent degeneration and vision loss. The short-lived African turquoise kililfsh (Nothobranchius furzeri GRZ-AD) is an ideal genetic model for ageing studies, exhibiting rapid ageing phenotypes within its four to six-mont lifespan. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30851
30 Samples

Download data: CSV, TXT

Series

Accession:: GSE255363

ID:: 200255363

PubMed

Select item 2002553646.

Identification of retinal cell types within the ageing African turquoise killifish retina and their respective age-related transcriptional changes using scRNA-seq

(Submitter supplied) The mammalian central nervous system (CNS) and its retina are susceptible to age-related patholgoies, resulting in progressive, irreversible diseases like glaucoma and age-related macular degeneration (AMD), which are increasingly prevalent with rising life expectancy. Currently, there are no targeted long-term therapies to prevent vision loss. The short lived African turquoise killifsh (Nothobranchius furzeri, GRZ-AD) is a valuable genetic model for ageing studies, displaying rapid ageing phenotypes within its four to six-month lifespan. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
6 Samples

Download data: CSV, MTX

Series

Accession:: GSE255364

ID:: 200255364

PubMed Full text in PMC Similar studies

Select item 2001830377.

RNA-Seq of Nothobranchius furzeri brain of male fishes of two strains (MZM_A41 and MZM-0410) of age 39/35 dph (days post hatch)

(Submitter supplied) A vast body of studies is available that describes age-dependent gene expression in relationship to aging in a number of different model species. These data were obtained from animals kept in conditions with reduced environmental challenges, abundant food and deprivation of natural sensory stimulation. Here we compared wild- and captive-aging in the short-lived turquoise killifish (Nothobranchius furzeri). more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19871
8 Samples

Download data: XLS

Series

Accession:: GSE183037

ID:: 200183037

PubMed SRA Run Selector

Select item 2001858178.

Comparative seq Between Killifish Species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Austrofundulus limnaeus; Aphyosemion australe; Iconisemion striatum; Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

8 related Platforms
175 Samples

Download data

Series

Accession:: GSE185817

ID:: 200185817

PubMed Similar studies

Select item 2001858169.

Comparative ATACseq Between Killifish Species

(Submitter supplied) We evaluate the global chromatin changes that occur during the developmental progression and development-to-diapause transition in a closely related set of killifish species.

Organism:: Aphyosemion australe; Nothobranchius furzeri; Austrofundulus limnaeus; Iconisemion striatum

Type:: Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
30 Samples

Download data: TXT

Series

Accession:: GSE185816

ID:: 200185816

PubMed Similar studies SRA Run Selector

Select item 20018581510.

Comparative RNAseq Between Killifish Species

(Submitter supplied) We evaluate the global gene expression changes that occur during a stage-matched developmental window in a closely related set of killifish species.

Organism:: Nothobranchius furzeri; Iconisemion striatum; Aphyosemion australe

Type:: Expression profiling by high throughput sequencing

4 related Platforms
145 Samples

Download data: CSV

Series

Accession:: GSE185815

ID:: 200185815

PubMed Similar studies SRA Run Selector

Select item 20025324111.

Gene expression profiles of the liver and skeletal muscle in germ-cell-removed animals

(Submitter supplied) The function of germ cells in somatic growth and aging is demonstrated in invertebrate models but remains unclear in vertebrates. Here, we demonstrate sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ-cell-removal shortened lifespan, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ-cell-removal in males improved their health state with increased vitamin D signaling. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
2 Samples

Download data: TSV, TXT

Series

Accession:: GSE253241

ID:: 200253241

PubMed Full text in PMC Similar studies

Select item 20026362612.

RNA sequencing of gonad tissue of Nothobranchius furzeri at different age in males and females

(Submitter supplied) Quantification of gene expression at different dvelopmental stages of the short-lived killifish Nothobranchius furzeri GRZ strain.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19871
19 Samples

Download data: CSV

Series

Accession:: GSE263626

ID:: 200263626

Select item 20026062913.

Positional information modulates transient regeneration-activated cell states during vertebrate appendage regeneration.

(Submitter supplied) Injury is a common occurrence in the life of most if not all organisms. Because injury and the extent of damage inflicted are not predictable events, pre-existing tissues must somehow determine how much tissue needs to be restored. It has been known for over a century that amputation position along a proximal-distal (P/D) axis determines the regeneration speed of amputated limbs in regeneration-competent animals1. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
32 Samples

Download data: H5, TXT

Series

Accession:: GSE260629

ID:: 200260629

PubMed

Select item 20024874114.

The germline regulates longevity and somatic repair in a sex-specific manner

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33195 GPL30852
51 Samples

Download data: CSV

Series

Accession:: GSE248741

ID:: 200248741

PubMed Similar studies

Select item 20024873915.

The germline regulates longevity and somatic repair in a sex-specific manner (RNA-Seq)

(Submitter supplied) Classical evolutionary theories propose tradeoffs between reproduction, damage repair, and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. Here, we use the turquoise killifish (N. furzeri) to genetically arrest germline differentiation at discrete stages, and examine how different ‘flavors’ of infertility impact life-history. We first constructed a comprehensive single-cell gonadal atlas, providing cell-type-specific markers for downstream phenotypic analysis. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33195
28 Samples

Download data: CSV

Series

Accession:: GSE248739

ID:: 200248739

PubMed Similar studies

Select item 20021897116.

Chromosome conformation capture (Hi-C) of the turquoise killifish

(Submitter supplied) This approach was used to increase the continuity of the killifish genome, and assess the relative distance of specific genes from the sex locus.

Organism:: Nothobranchius furzeri

Type:: Other

Platform:: GPL30852
2 Samples

Download data: FASTA, HIC

Series

Accession:: GSE218971

ID:: 200218971

PubMed Similar studies

Select item 20021862217.

Signals from the reproductive system regulate somatic regeneration and vertebrate lifespan

(Submitter supplied) In many vertebrate species, age at maturity is proportional to organismal lifespan. A number of theories have attempted to provide a conceptual framework for this fascinating apparent co-evolution. The ‘disposable soma’ theory predicts that costly resources that are invested in germline preservation come at the expense of repairing age-related somatic damage. On the other hand, classical experiments in C. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30852
23 Samples

Download data: CSV

Series

Accession:: GSE218622

ID:: 200218622

PubMed Similar studies

Select item 20020774818.

A cross-sectional study of gene expression in different strains of Nothobranchius furzeri

(Submitter supplied) We quantified gene expression in three different strains of the short-lived killifish Nothobranchius furzeri during aging.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19871
168 Samples

Download data: CSV

Series

Accession:: GSE207748

ID:: 200207748

Select item 20019075719.

Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate

(Submitter supplied) During aging, the loss of metabolic homeostasis drives a myriad of pathologies. A central regulator of cellular energy, the AMP-activated protein kinase (AMPK), orchestrates organismal metabolism. However, direct genetic manipulations of the AMPK complex in mice have, so far, produced detrimental phenotypes. Here, as an alternative approach, we alter energy homeostasis by manipulating the upstream nucleotide pool. more...