GEO DataSets

(Submitter supplied) This study investigates host transcriptome changes of infected human iPS-derived brain endothelial cells in response to prolonged Nm infection (24h)

Organism:

Homo sapiens; Neisseria meningitidis MC58

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26178 GPL18573

2 Samples

Download data: WIG

(Submitter supplied) Neisseria meningitidis is an obligate commensal colonising the human nasopharynx and occasionally invades the bloodstream causing life-threatening meningitis and septicaemia. The gene NMB0419 on the genome of N. meningitidis MC58 encodes a putative Sel1-like repeat (SLR) containing protein, which has been implicated in mediating meningococcal invasion of epithelial cells. We prepared RNA samples from N. more...

Organism:

Neisseria meningitidis MC58

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21879

6 Samples

Download data: TXT

(Submitter supplied) Neisseria meningitidis remains an important cause of septicemia and meningitis. One of its major virulence traits is its ability to avoid killing by human serum. In the present work, the effect of growth phase (exponential versus stationary) and growth medium (THB versus Catlin) on normal human serum (NHS) sensitivity was assessed on two N. meningitidis serogroup B strains (MC58 and M982). Both strains were found to be dramatically more resistant to 20% NHS killing at early exponential phase than at stationary phase (73-100% survival after 1 to 2 hours of growth compared to less than 10% survival after 7 hours of growth). more...

Organism:

Neisseria meningitidis; Neisseria meningitidis MC58

Type:

Expression profiling by array

Platform:

GPL11321

9 Samples

Download data: GPR

(Submitter supplied) In Neisseria meningitidis iron responsive gene regulation is mediated primarily by the Ferric Uptake Regulator (Fur) protein. When complexed with iron, Fur represses gene expression by preventing transcription initiation. Fur can also indirectly activate gene expression via the repression of regulatory small RNAs (sRNA). One such Fur-and iron-regulated sRNA, NrrF, was previously identified in N. meningitidis and shown to repress expression of the sdhA and sdhC genes encoding subunits of the succinate dehydrogenase complex. more...

Organism:

Neisseria meningitidis MC58

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL10038

18 Samples

Download data: PAIR

(Submitter supplied) See manufacturer's web site.

Organism:

Neisseria meningitidis MC58

1 Series

9 Samples

Download data

(Submitter supplied) DNA microarrays were designed by Nimblegen Inc. (Nimblegen, Madison, WI) using the N. meningitidis MC58 genome as a reference (Genbank, accession # NC_003112) (Tettelin et al., 2000). Arrays were designed using the Nimblegen 4-plexTM format consisting of four arrays on each individual chip. Each array contained 72,000 probes, for a total of 385,000 probes per chip. For interrogation of each target open reading frame, ten unique corresponding 60-mer synthetic DNA oligonucleotide probes were synthesized directly onto Nimblegen 4-plexTM arrays, and each probe was printed in duplicate. more...

Organism:

Neisseria meningitidis MC58

1 Series

18 Samples

Download data: NDF, NGD