GEO DataSets

(Submitter supplied) Moraxella catarrhalis contains an N6-adenine DNA-methyltransferase (ModM3), that is subject to phase variable expression (random ON/OFF switching). Phase-variable switching of DNA methyltransferase activity results in the presence or absence of methylation at a specific target sequence, leading to co-ordinated, epigenetically-regulated switching of expression of multiple genes across the genome. The suite of genes thus regulated are known as a phasevarion (phase-variable regulon). more...

Organism:

Moraxella catarrhalis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27756

6 Samples

Download data: TXT

(Submitter supplied) Transcription profile analysis of a wild type ETSU9 strain and its isogenic non-polar in frame mesR mutant.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

6 Samples

Download data: GPR

(Submitter supplied) The complement system is an important part of the innate defense against invading pathogens. The ability to resist complement-mediated killing is considered to be an important virulence trait for the human-restricted respiratory tract pathogen M. catarrhalis, as most disease-associated M. catarrhalis isolates are complement-resistant. Here we studied the molecular basis of M. catarrhalis complement-resistance by transcriptome profiling upon exposure to 10% normal human serum (NHS).

Organism:

Moraxella catarrhalis BBH18

Type:

Expression profiling by array

Platform:

GPL17283

11 Samples

Download data: PAIR

(Submitter supplied) In this study, DNA microarray technology was used to measure global gene expression in M. catarrhalis cells that had attached to human bronchial epithelial cells in culture.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

5 Samples

Download data: GPR

(Submitter supplied) This series of microarrays explores the genes regulated by the Zur gene of Moraxella catarrhalis.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

4 Samples

Download data: GPR

(Submitter supplied) Analysis of the gene expression pattern of a znuA mutant constructed in the O35E background. It's pattern of expression was compared to that of O35E.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

6 Samples

Download data: GPR

(Submitter supplied) Comparison of the gene expression profile of Moraxella catarrhalis grown in the presence of 20% pooled human sputum in chemically-defined medium relative to Moraxella catarrhalis grown in chemically-defined medium alone.

Organism:

Moraxella catarrhalis ATCC 43617; Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

6 Samples

Download data: GPR

(Submitter supplied) Background: Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid downshifts of environmental temperature when humans breathe cold air. The prevalence of pharyngeal colonization and respiratory tract infections caused by M. catarrhalis is greatest in winter. We investigated how M. catarrhalis uses the physiologic exposure to cold air to regulate pivotal survival systems that may contribute to M. more...

Organism:

Moraxella catarrhalis O35E

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17097

6 Samples

Download data: BED, TSV

(Submitter supplied) During the course of infection, respiratory pathogens like Moraxella catarrhalis needs to adhere to epithelial cells of different host niches such as the nasopharynx and lungs. Consequently, efficient adhesion to epithelial cells is considered an important virulence trait of M. catarrhalis. We examined the interaction between human pharyngeal epithelial Detroit 562 cells and M. catarrhalis BBH18 during adherence using a combination of Tn-seq, a genome-wide negative selection screenings technology, and expression profiling of both host and pathogen. more...

Organism:

Moraxella catarrhalis; Moraxella catarrhalis BBH18

Type:

Expression profiling by array

Platform:

GPL17283

11 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Moraxella catarrhalis BBH18

Type:

Expression profiling by array; Other; Genome variation profiling by genome tiling array

Platforms:

GPL16172 GPL16171

100 Samples

Download data: PAIR

(Submitter supplied) Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation using the high-throughput genome-wide screening technology genomic array footprinting (GAF). To further characterize the functional consequences of the gene deletions (GAF identified genes), we determined transcriptome profiles of the wild-type and directed mutant strains during exponential growth in BHI medium. more...

Organism:

Moraxella catarrhalis BBH18

Type:

Expression profiling by array

Platform:

GPL16172

76 Samples

Download data: PAIR

(Submitter supplied) Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation using the high-throughput genome-wide screening technology genomic array footprinting (GAF). To this end, a large marinerT7 transposon mutant library (~28,000 independent transposon mutants) was grown under iron-limiting conditions, achieved by sequestration of iron by 30 µM Desferal (DF30), and under control growth conditions (brain heart infusion broth, DF0). more...

Organism:

Moraxella catarrhalis BBH18

Type:

Genome variation profiling by genome tiling array; Other

Platform:

GPL16171

24 Samples

Download data: PAIR

(Submitter supplied) M. catarrhalis strain O35E.rpsl was inoculated into the nasopharynx of healthy, male adult chinchillas. 24 hours later the nasopharyngeal tissues were extracted and homogenized. Total RNA was extracted from these tissue samples. Subsequently, M. catarrhalis genome directed primers were utilized to synthesize cDNA from the total RNA sample. As a control, M.catarrhalis strain O35E.rpsl was grown in BHI broth to a Klett density of 200 units and underwent RNA extraction per standard protocols. more...

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

5 Samples

Download data: GPR

(Submitter supplied) Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E and M. catarrhalis oxyR mutant response to 50 mM hydrogen peroxide.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

4 Samples

Download data: GPR

(Submitter supplied) Series of DNA microarrays (4) comparing the M. catarrhalis strain 035E response to 50 mM hydrogen peroxide relative to a water-only control.

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platform:

GPL7398

4 Samples

Download data: GPR

(Submitter supplied) Transcriptome analysis of M. catarrhalis RH4 predicted coding sequences and clustered regularly interspaced short palindromic repeats (CRISPRs) regions. The results described in this study are further discussed in De Vries, S.P.W., van Hijum, S.A.F.T., Schueler, W., Riesbeck, K., Hays, J.P., Hermans, P.W.M., Bootsma, H.J.; Genome analysis of Moraxella catarrhalis strain RH4: a human respiratory tract pathogen; Journal of Bacteriology

Organism:

Moraxella catarrhalis RH4; Moraxella catarrhalis BBH18

Type:

Expression profiling by genome tiling array

Platform:

GPL10378

18 Samples

Download data: PAIR

(Submitter supplied) Total RNA samples were isolated from M. catarrhalis grown in the planktonic state (i.e., in broth) and in a biofilm. Biofilms were generated by growing this strain in the continuous-flow Sorbarod filter system for three days. Total RNA samples and M. catarrhalis genome-directed primers (GDPs) were used for synthesis of Cy3- or Cy5-labeled cDNA samples. Five independent M. catarrhalis growth experiments and total RNA isolations were used for the synthesis of cDNA samples, and a total of six DNA microarray hybridizations were performed in this study. more...

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platforms:

GPL3479 GPL3478

6 Samples

Download data: GPR

(Submitter supplied) Total RNA samples were isolated from M. catarrhalis grown in BHI (iron-replete condition, designated DF0) and in BHI containing 30 mM Desferal (iron-limiting condition, designated DF30). Total RNA and M. catarrhalis genome-directed primers (GDPs) were used for synthesis of Cy3- or Cy5-labeled cDNA samples. Three independent M. catarrhalis growth experiments and total RNA isolations were used for synthesis of cDNA samples, and a total of six DNA microarray hybridizations were performed in this study. more...

Organism:

Moraxella catarrhalis

Type:

Expression profiling by array

Platforms:

GPL3478 GPL3479

6 Samples

Download data: GPR