GEO DataSets

(Submitter supplied) C57BL/6 mice were immunized with Coxiella burnetii vaccine Q-VAX (Seqirus) and monitored for up to 83 days post immunization. Two different routes of immunization were observed - subcutaneous and intramuscular. Subcutaneously immunized animals were boosted on day 67.

Organism:

Coxiella burnetii; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL33327

40 Samples

Download data: CSV

(Submitter supplied) Coxiella burnetii, the etiological agent of Q fever, undergoes a unique biphasic developmental cycle where bacteria transition from replicating (exponential phase) large cell variant (LCV) forms to a non-replicating, (stationary phase) small cell variant (SCV) forms. The alternative sigma factor RpoS is an essential regulator of stress responses and stationary phase growth in several bacterial species, including Legionella pneumophila, which has a developmental cycle superficially similar to C. more...

Organism:

Coxiella burnetii

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24577

11 Samples

Download data: TXT

(Submitter supplied) The pathogenic spirochete Borrelia burgdorferi senses and responds to diverse environmental challenges, including changes in nutrient availability, throughout its natural infectious cycle in Ixodes spp. ticks and mammalian hosts. This study examined the role of the putative DnaK suppressor protein (DksA) in the transcriptional response of B. burgdorferi to starvation. Wild-type and dksA-deficient B. more...

Organism:

Coxiella burnetii; Streptococcus pyogenes; Yersinia pestis; Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL2129

12 Samples

Download data: CEL, CHP

(Submitter supplied) Several methicillin resistance (SCCmec) clusters characteristic of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) strains harbor the psm-mec locus. In addition to encoding the cytolysin, phenol-soluble modulin (PSM) mec, this locus has been attributed gene regulatory functions. Here we employed genome-wide transcriptional profiling to define the regulatory function of the psm-mec locus. more...

Organism:

Staphylococcus aureus; Coxiella burnetii; Yersinia pestis; Streptococcus pyogenes; Borreliella burgdorferi; Chlamydia trachomatis

Type:

Expression profiling by array

Platform:

GPL2129

12 Samples

Download data: CEL, CHP

(Submitter supplied) As vector-borne pathogens transit between the arthropod and vertebrate, adaptation is key for survival as each host varies and initiates unique defense mechanisms. An environmental signal that relapsing fever (RF) and Lyme causing spirochetes detect is the change of temperature between vector and mammal, yet incomplete genomes have hindered progress in understanding the genetic constituents expressed during tick colonization. more...

Organism:

Brucella suis; Coxiella burnetii; Rickettsia prowazekii; Borrelia hermsii; Burkholderia mallei; Borrelia turicatae 91E135; Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL7246

9 Samples

Download data: CEL, CHP

(Submitter supplied) The Yersinia pestis PhoPQ gene regulatory system is induced during infection of the flea digestive tract and is required to produce adherent biofilm in the foregut, which greatly enhances bacterial transmission during a flea bite. To understand the in vivo context of PhoPQ induction and to determine PhoP-regulated targets in the flea, we undertook whole genome comparative transcriptional profiling of Y. more...

Organism:

Yersinia pestis; Borreliella burgdorferi; Staphylococcus aureus; Coxiella burnetii; Chlamydia trachomatis; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL2129

40 Samples

Download data: CEL, CHP

(Submitter supplied) Bacterial sepsis is a major killer in hospitalized patients. Coagulase-negative staphylococci (CNS) with the leading species Staphylococcus epidermidis are the most frequent causes of nosocomial sepsis, with most infectious isolates being methicillin resistant. However, which bacterial factors underlie the pathogenesis of CNS sepsis is unknown. While it has been commonly believed that invariant structures on the surface of CNS trigger sepsis by causing an over-reaction of the immune system, we show here that sepsis caused my methicillin-resistant S. more...

Organism:

Staphylococcus epidermidis ATCC 12228; Chlamydia trachomatis D/UW-3/CX; Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435; Staphylococcus epidermidis; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis

Type:

Expression profiling by array

Platform:

GPL4692

15 Samples

Download data: CEL, CHP

(Submitter supplied) Virulence of many bacterial pathogens, including the important human pathogen Staphylococcus aureus, depends on the secretion of frequently high amounts of toxins. Toxin production involves the need for the bacteria to make physiological adjustments for energy conservation. While toxins are primarily known to be targets of gene regulation, such changes may be accomplished by regulatory functions of the toxins themselves. more...

Organism:

Coxiella burnetii; Rickettsia rickettsii; Staphylococcus aureus; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Borreliella burgdorferi B31; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Chlamydia pneumoniae AR39; Coxiella burnetii RSA 493; Granulibacter bethesdensis

Type:

Expression profiling by array

Platform:

GPL4692

12 Samples

Download data: CEL, CHP

(Submitter supplied) A hallmark of Coxiella burnetii, the bacterial cause of human Q fever, is a biphasic developmental cycle that generates biologically, ultrastructurally, and compositionally distinct large cell variant (LCV) and small cell variant (SCV) forms. LCVs are replicating, exponential phase forms while SCVs are non-replicating, stationary phase forms. The SCV has several properties, such as a condensed nucleoid and an unusual cell envelope, suspected of conferring enhanced environmental stability. more...

Organism:

Chlamydia pneumoniae AR39; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Coxiella burnetii; Chlamydia trachomatis D/UW-3/CX; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435

Type:

Expression profiling by array

Platform:

GPL4692

20 Samples

Download data: CEL, CHP

(Submitter supplied) Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter bethesdensis is an emerging Gram-negative pathogen in CGD that resists killing by CGD PMN and inhibits PMN apoptosis through unknown mechanisms. more...

Organism:

Coxiella burnetii; Rickettsia rickettsii; Staphylococcus epidermidis ATCC 12228; Chlamydia caviae GPIC; Homo sapiens; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Staphylococcus aureus subsp. aureus MW2; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Chlamydia pneumoniae AR39; Granulibacter bethesdensis

Type:

Expression profiling by array

Platforms:

GPL570 GPL4692

123 Samples

Download data: CEL, CHP

(Submitter supplied) Spirochetes are long, thin, motile, helical or flat wave bacteria that are unique among the prokaryotes by having flagella or axial filaments confined to an internal periplasmic space. These flagella are complex organelles that can play major roles in bacterial pathogenicity and are used as propellers allowing bacteria to move through liquids, viscous environments or along surfaces. While most bacteria species use transcriptional regulatory cascades to regulate the synthesis and assembly of their flagella, spirochetes employ an unusual post-transcriptional mechanism. more...

Organism:

Francisella tularensis; Coxiella burnetii; Rickettsia prowazekii; Burkholderia mallei; Borrelia hermsii; Brucella suis

Type:

Expression profiling by array

Platform:

GPL7246

24 Samples

Download data: CEL, CHP

(Submitter supplied) Coxiella burnetii undergoes a biphasic developmental cycle within its host cell that generates morphologically and physiologically distinct large cell variants (LCV) and small cell variants (SCV). During the lag phase of the C. burnetii growth cycle, non-replicating SCV differentiate into replicating LCV that in turn differentiate back into SCV during stationary phase. Nearly homogeneous SCV are observed in infected Vero cells after extended incubation (21 to 28 days). more...

Organism:

Coxiella burnetii; Rickettsia rickettsii; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Borreliella burgdorferi B31; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Chlamydia pneumoniae AR39; Coxiella burnetii RSA 493; Granulibacter bethesdensis

Type:

Expression profiling by array

Platform:

GPL4692

8 Samples

Download data: CEL, CHP

(Submitter supplied) Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract of global medical importance. The chlamydial plasmid plays an important role in the pathophysiology of these diseases as plasmid-deficient organisms are highly attenuated. The plasmid encodes both noncoding RNAs and eight conserved ORFs of undefined function. To understand plasmid gene function we generated plasmid shuttle vectors with deletions in each of the eight ORFs. more...

Organism:

Chlamydia trachomatis; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia trachomatis D/UW-3/CX; Coxiella burnetii; Rickettsia rickettsii; Chlamydia pneumoniae AR39; Staphylococcus epidermidis ATCC 12228; Chlamydia caviae GPIC; Granulibacter bethesdensis; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Staphylococcus aureus subsp. aureus MW2; Staphylococcus haemolyticus JCSC1435

Type:

Expression profiling by array

Platform:

GPL4692

36 Samples

Download data: CEL, CHP

(Submitter supplied) Chlamydia trachomatis is a significant human pathogen yet their obligate intracellular nature severe restrictions upon research. Chlamydiae undergo a complex developmental cycle characterized by an infectious cell type known as the elementary body (EB) and an intracellular active replicative form called the reticulate body (RB). EBs have historically been described as metabolically dormant. A cell-free (axenic) culture system was developed which showed high levels of metabolic and biosynthetic activity from both EBs and RBs. more...

Organism:

Chlamydia pneumoniae AR39; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia trachomatis; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia caviae GPIC; Chlamydia trachomatis D/UW-3/CX; Staphylococcus haemolyticus JCSC1435; Coxiella burnetii; Rickettsia rickettsii; Staphylococcus epidermidis ATCC 12228

Type:

Expression profiling by array

Platform:

GPL4692

20 Samples

Download data: CEL, CHP

(Submitter supplied) Genotyping based on genomic comparative hybridization of different isolates of coxiella burnetii compared to NMI reference strain

Organism:

Coxiella burnetii

Type:

Genome variation profiling by array

Platform:

GPL6675

52 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Coxiella burnetii phase I (RSA 493) submitting either to Cold and Heat shock comparing to control untreated Coxiella burnetii phase I (RSA 493) grown at 35°C.

Organism:

Coxiella burnetii

Type:

Expression profiling by array

Platform:

GPL6675

12 Samples

Download data: TXT

(Submitter supplied) Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37°C induces many known virulence factors of Y. pestis that confer resistance to innate immunity. These factors are not produced in the low-temperature environment of the flea, however, suggesting that Y. more...

Organism:

Coxiella burnetii; Chlamydia trachomatis; Streptococcus pyogenes; Borreliella burgdorferi; Staphylococcus aureus; Yersinia pestis

Type:

Expression profiling by array

Platform:

GPL2129

24 Samples

Download data: CEL, CHP

(Submitter supplied) Methicillin-resistant Staphylococcus aureus (MRSA) is problematic both in hospitals and the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S two-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. more...

Organism:

Chlamydia pneumoniae AR39; Staphylococcus epidermidis ATCC 12228; Staphylococcus aureus subsp. aureus MW2; Granulibacter bethesdensis; Staphylococcus aureus; Chlamydia muridarum; Staphylococcus epidermidis RP62A; Chlamydia caviae GPIC; Staphylococcus haemolyticus JCSC1435; Coxiella burnetii; Rickettsia rickettsii; Borreliella burgdorferi B31; Coxiella burnetii RSA 493; Chlamydia trachomatis D/UW-3/CX

Type:

Expression profiling by array

Platform:

GPL4692

12 Samples

Download data: CEL, CHP

(Submitter supplied) The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Query) fever, is an obligate intracellular bacterial pathogen that replicates exclusively in an acidified, lysosome-like vacuole. more...

Organism:

Yersinia pestis; Streptococcus pyogenes; Coxiella burnetii; Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL2129

9 Samples

Download data: CEL, CHP

(Submitter supplied) Two covR mutant derivatives of parental strain MGAS2221 were recovered from mice experimentally infected with MGAS2221 and shown to differ in terms of the number and concentration of secreted proteins. One of the covR mutant strains had a secretion phenotype identical to a covS mutant strain, while the other had a secretion phenotype identical to a constructed covR mutant strain. To further investigate the potential differences between the two covR mutant strains we performed expression microarray analysis.

Organism:

Coxiella burnetii; Borreliella burgdorferi; Yersinia pestis; Staphylococcus aureus; Chlamydia trachomatis; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL2129

4 Samples

Download data: CEL