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sap130a Sin3A-associated protein a [ Danio rerio (zebrafish) ]

Gene ID: 100073341, updated on 4-Jan-2025

Summary

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Official Symbol
sap130aprovided by ZNC
Official Full Name
Sin3A-associated protein aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070615-5
See related
Ensembl:ENSDARG00000056924 AllianceGenome:ZFIN:ZDB-GENE-070615-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:162722
Summary
Predicted to enable glucan 1,4-alpha-glucosidase activity. Acts upstream of or within several processes, including floor plate formation; larval locomotory behavior; and thigmotaxis. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Used to study hypoplastic left heart syndrome. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sap130a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (28018390..28049599)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (28027817..28059038)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene angiomotin like 2a Neighboring gene unconventional myosin-VIIa Neighboring gene si:ch73-194h10.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The complex genetics of hypoplastic left heart syndrome. Liu X, et al. Nat Genet, 2017 Jul. PMID 28530678, Free PMC Article
  2. Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. DeMoya RA, et al. Front Cell Dev Biol, 2023. PMID 37711853, Free PMC Article
  3. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glucan 1,4-alpha-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within floor plate formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within larval locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thigmotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone deacetylase complex subunit SAP130a
NP_001092247.2
XP_005165953.1
XP_009300663.1
XP_017211908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098777.2 → NP_001092247.2  histone deacetylase complex subunit SAP130a

    Status: VALIDATED

    Source sequence(s)
    CR626936, CR626940
    UniProtKB/TrEMBL
    A0A8M1NEX8, F1REK0
    Related
    ENSDARP00000112480.2, ENSDART00000123324.4
    Conserved Domains (1) summary
    pfam16014
    Location:651 → 1055
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    28018390..28049599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302388.4 → XP_009300663.1  histone deacetylase complex subunit SAP130a isoform X2

    UniProtKB/TrEMBL
    A0A8M3ATE0
    Conserved Domains (1) summary
    pfam16014
    Location:634 → 1038
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

  2. XM_017356419.2 → XP_017211908.1  histone deacetylase complex subunit SAP130a isoform X3

    UniProtKB/TrEMBL
    A0A8M6YZH6

  3. XM_005165896.2 → XP_005165953.1  histone deacetylase complex subunit SAP130a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BD75
    Conserved Domains (1) summary
    pfam16014
    Location:650 → 1054
    SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394645.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    633..13975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395255.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    633..12572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395378.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    633..13975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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