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cables2a Cdk5 and Abl enzyme substrate 2a [ Danio rerio (zebrafish) ]

Gene ID: 100148748, updated on 4-Jan-2025

Summary

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Official Symbol
cables2aprovided by ZNC
Official Full Name
Cdk5 and Abl enzyme substrate 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091118-58
See related
Ensembl:ENSDARG00000076964 AllianceGenome:ZFIN:ZDB-GENE-091118-58
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-202m22.8
Summary
Predicted to act upstream of or within regulation of cell cycle. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cables2a in Genome Data Viewer
Location:
chromosome: 23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (30898005..30920943)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (30971465..30994690)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene delta-type opioid receptor Neighboring gene XK related 7a Neighboring gene oxysterol binding protein-like 2a Neighboring gene si:ch211-197l9.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDK5 and ABL1 enzyme substrate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    30898005..30920943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919790.8 → XP_001919825.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q830, E9QCE8
    Related
    ENSDARP00000116145.1, ENSDART00000146859.2
    Conserved Domains (2) summary
    cd00043
    Location:389 → 480
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl28033
    Location:2 → 191
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. XM_005162339.5 → XP_005162396.1  CDK5 and ABL1 enzyme substrate 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B986
    Conserved Domains (2) summary
    cd00043
    Location:363 → 454
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl28033
    Location:2 → 191
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395158.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    629394..652332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473725.2 → XP_021329400.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q830, E9QCE8
    Conserved Domains (2) summary
    cd00043
    Location:389 → 480
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl28033
    Location:2 → 191
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. XM_021473726.2 → XP_021329401.1  CDK5 and ABL1 enzyme substrate 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B986
    Conserved Domains (2) summary
    cd00043
    Location:363 → 454
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl28033
    Location:2 → 191
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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