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Dhx29 DExH-box helicase 29 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362324, updated on 4-Jan-2025

Summary

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Official Symbol
Dhx29provided by RGD
Official Full Name
DExH-box helicase 29provided by RGD
Primary source
RGD:2318361
See related
EnsemblRapid:ENSRNOG00000010369 AllianceGenome:RGD:2318361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including nucleic acid binding activity; ribonucleoside triphosphate phosphatase activity; and ribosomal small subunit binding activity. Predicted to be involved in formation of translation preinitiation complex and ribosome assembly. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic 43S preinitiation complex. Orthologous to human DHX29 (DExH-box helicase 29). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 72.7), Thymus (RPKM 70.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhx29 in Genome Data Viewer
Location:
2q14
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46293901..46344652)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44560653..44611450)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44787066..44837834)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100707 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Hashem Y, et al. Cell, 2013 May 23. PMID 23706745, Free PMC Article
  2. Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. Dhote V, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23047696, Free PMC Article
  3. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Parsyan A, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20018725, Free PMC Article
  4. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 43S preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DHX29
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 29
DEAH-box helicase 29
NP_001414443.1
XP_006232012.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427514.1 → NP_001414443.1  ATP-dependent RNA helicase DHX29

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6G8D3, D3ZHW0
    Related
    ENSRNOP00000013854.6, ENSRNOT00000013854.10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    46293901..46344652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231950.5 → XP_006232012.1  ATP-dependent RNA helicase DHX29 isoform X1

    See identical proteins and their annotated locations for XP_006232012.1

    UniProtKB/TrEMBL
    A0A8I6G8D3
    Related
    ENSRNOP00000109199.1, ENSRNOT00000140602.1
    Conserved Domains (5) summary
    smart00487
    Location:578 → 764
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:1056 → 1137
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:589 → 736
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:864 → 985
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:1179 → 1299
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein Strain
Heading Accession and Version

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