Chaf1b chromatin assembly factor 1, subunit B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chaf1bprovided by MGI
Official Full Name: chromatin assembly factor 1, subunit Bprovided by MGI
Primary source: MGI:MGI:1314881
See related: Ensembl:ENSMUSG00000022945 AllianceGenome:MGI:1314881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAF1; CAF1A; CAF1P60; CAF-Ip60; MPHOSPH7; CAF-I p60; 2600017H24Rik
Summary: Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in CNS E11.5 (RPKM 15.1), liver E14 (RPKM 14.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 54.96 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (93680801..93703003)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (93883900..93906115)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.
Title: Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.
CHAF1b, chromatin assembly factor-1 subunit b, is essential for mouse preimplantation embryos.
Title: CHAF1b, chromatin assembly factor-1 subunit b, is essential for mouse preimplantation embryos.
Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice.
Title: Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice.
CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia.
Title: A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

14.MMHAP15FLE2.seq (e-PCR)
- UniSTS:123197

BG377971 (e-PCR)
- UniSTS:244544

C76145 (e-PCR)
- UniSTS:160596

Chaf1b (e-PCR), detects polymorphism
- UniSTS:259053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication-dependent chromatin assembly	ISO Inferred from Sequence Orthology more info
involved_in DNA replication-dependent chromatin assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CAF-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAF-1 complex	ISO Inferred from Sequence Orthology more info
part_of CAF-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromatin assembly factor 1 subunit B

Names: CAF-1 subunit B; CAF-I 60 kDa subunit; chromatin assembly factor 1, subunit B (p60); chromatin assembly factor I p60 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419178.1 → NP_001406107.1 chromatin assembly factor 1 subunit B isoform 1

Status: VALIDATED

Source sequence(s)

AC168220

UniProtKB/Swiss-Prot

Q9D0N7
NM_001419179.1 → NP_001406108.1 chromatin assembly factor 1 subunit B isoform 1

Status: VALIDATED

Source sequence(s)

AC168220

UniProtKB/Swiss-Prot

Q9D0N7

Related

ENSMUSP00000113684.2, ENSMUST00000117099.8
NM_001419180.1 → NP_001406109.1 chromatin assembly factor 1 subunit B isoform 2

Status: VALIDATED

Source sequence(s)

AC168220
NM_001419181.1 → NP_001406110.1 chromatin assembly factor 1 subunit B isoform 3

Status: VALIDATED

Source sequence(s)

AC168220
NM_001419182.1 → NP_001406111.1 chromatin assembly factor 1 subunit B isoform 4

Status: VALIDATED

Source sequence(s)

AC168220
NM_001419183.1 → NP_001406112.1 chromatin assembly factor 1 subunit B isoform 5

Status: VALIDATED

Source sequence(s)

AC168220
NM_028083.5 → NP_082359.1 chromatin assembly factor 1 subunit B isoform 1

See identical proteins and their annotated locations for NP_082359.1

Status: VALIDATED

Source sequence(s)

AC168220

Consensus CDS

CCDS28344.1

UniProtKB/Swiss-Prot

Q9D0N7

Related

ENSMUSP00000023666.5, ENSMUST00000023666.11

Conserved Domains (3) summary

sd00039
Location:21 → 64

7WD40; WD40 repeat [structural motif]

pfam15512
Location:388 → 561

CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

cl29593
Location:13 → 251

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...