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Strn3 striatin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114520, updated on 27-Nov-2024

Summary

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Official Symbol
Strn3provided by RGD
Official Full Name
striatin 3provided by RGD
Primary source
RGD:621827
See related
EnsemblRapid:ENSRNOG00000060335 AllianceGenome:RGD:621827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gs2na; Sg2na
Summary
Predicted to enable several functions, including armadillo repeat domain binding activity; calmodulin binding activity; and enzyme binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of intracellular estrogen receptor signaling pathway; and response to estradiol. Located in dendrite and neuronal cell body. Part of protein-containing complex. Orthologous to human STRN3 (striatin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 465.8), Heart (RPKM 328.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Strn3 in Genome Data Viewer
Location:
6q23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74783156..74869473, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69047776..69134102, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72376360..72462676, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor like GTPase 1, pseudogene 1 Neighboring gene cochlin Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene uncharacterized LOC120103536 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134479181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress. Bisoyi P, et al. Cell Mol Neurobiol, 2023 Oct. PMID 37165139
  2. Expression and distribution of phocein and members of the striatin family in neurones of rat peripheral ganglia. Blondeau C, et al. Histochem Cell Biol, 2003 Feb. PMID 12610732
  3. Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats. Zhu W, et al. Exp Cell Res, 2001 Oct 1. PMID 11570823
  4. Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase. Tan B, et al. J Mol Endocrinol, 2008 May. PMID 18434427
  5. Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Gaillard S, et al. Traffic, 2006 Jan. PMID 16445688

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
    Title: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
  2. A rat STRN3 gamma-protein phosphatase 2A complex is recruited to agonist-activated estrogen receptor alpha, thereby leading to its dephosphorylation and inhibiting transcription.
    Title: Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
part_of FAR/SIN/STRIPAK complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
striatin-3
Names
cell cycle autoantigen SG2NA
nuclear autoantigen
s/G2 antigen
striatin, calmodulin binding protein 3
striatin-3-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029897.3 → NP_001025068.1  striatin-3

    See identical proteins and their annotated locations for NP_001025068.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P58405
    Related
    ENSRNOP00000074395.1, ENSRNOT00000077578.3
    Conserved Domains (4) summary
    COG2319
    Location:463 → 792
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:472 → 793
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:482 → 528
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    74783156..74869473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240077.4 → XP_006240139.1  striatin-3 isoform X3

    UniProtKB/TrEMBL
    E9PT82
    Related
    ENSRNOP00000071600.1, ENSRNOT00000088720.3
    Conserved Domains (4) summary
    COG2319
    Location:379 → 708
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:388 → 709
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:398 → 444
    7WD40; WD40 repeat [structural motif]

  2. XM_006240075.4 → XP_006240137.1  striatin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGH7
    Related
    ENSRNOP00000087402.1, ENSRNOT00000106600.2
    Conserved Domains (4) summary
    COG2319
    Location:426 → 755
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:435 → 756
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:445 → 491
    7WD40; WD40 repeat [structural motif]

  3. XM_006240076.4 → XP_006240138.1  striatin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUH2
    Related
    ENSRNOP00000081686.1, ENSRNOT00000111997.2
    Conserved Domains (4) summary
    COG2319
    Location:320 → 745
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:425 → 746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:63 → 188
    Striatin; Striatin family
    sd00039
    Location:435 → 481
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58405.2 GenPept UniProtKB/Swiss-Prot:P58405

Gene LinkOut

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