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Y37E3.17 Dimethylglycine dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 171775, updated on 2-Nov-2024

Summary

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Official Symbol
Y37E3.17
Official Full Name
Dimethylglycine dehydrogenase, mitochondrial
Primary source
WormBase:WBGene00021355
Locus tag
CELE_Y37E3.17
See related
AllianceGenome:WB:WBGene00021355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dimethylglycine dehydrogenase activity. Predicted to be active in mitochondrial matrix. Used to study dimethylglycine dehydrogenase deficiency. Human ortholog(s) of this gene implicated in dimethylglycine dehydrogenase deficiency. Orthologous to human DMGDH (dimethylglycine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y37E3.17 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (2128588..2145971)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear pore protein Neighboring gene Uncharacterized protein Neighboring gene Solute carrier family 40 member Neighboring gene Rx N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
  2. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
  3. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dimethylglycine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Dimethylglycine dehydrogenase, mitochondrial
NP_001021745.1
  • Confirmed by transcript evidence
NP_001021746.1
  • Confirmed by transcript evidence
NP_001360455.1
  • Confirmed by transcript evidence
NP_001360456.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2128588..2145971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373685.2 → NP_001360455.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WV52
    Conserved Domains (2) summary
    COG0404
    Location:440 → 831
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:26 → 414
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  2. NM_001026574.4 → NP_001021745.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0N9
    Conserved Domains (6) summary
    COG0404
    Location:440 → 828
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01266
    Location:31 → 392
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:451 → 714
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:722 → 819
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam13450
    Location:32 → 88
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16350
    Location:395 → 446
    FAO_M; FAD dependent oxidoreductase central domain

  3. NM_001026575.7 → NP_001021746.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AW03
    Conserved Domains (6) summary
    COG0404
    Location:447 → 835
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:26 → 421
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:458 → 721
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:729 → 826
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam13450
    Location:32 → 95
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16350
    Location:402 → 453
    FAO_M; FAD dependent oxidoreductase central domain

  4. NM_001373684.2 → NP_001360456.1  Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WWC6
    Conserved Domains (2) summary
    COG0404
    Location:447 → 838
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:26 → 421
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
Nucleotide Protein
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