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lec-3 32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin [ Caenorhabditis elegans ]

Gene ID: 174557, updated on 23-Jan-2025

Summary

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Official Symbol
lec-3
Official Full Name
32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin
Primary source
WormBase:WBGene00002266
Locus tag
CELE_ZK892.1
See related
AllianceGenome:WB:WBGene00002266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity and galactoside binding activity. Located in plasma membrane. Orthologous to several human genes including LGALS9 (galectin 9) and LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lec-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (9991160..10000350)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Non-specific lipid-transfer protein-like 1 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
  2. A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Ideo H, et al. J Biol Chem, 2009 Sep 25. PMID 19635802, Free PMC Article
  3. General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia. Bae YK, et al. Development, 2006 Oct. PMID 16943275
  4. The matrisome landscape controlling in vivo germ cell fates. Amran A, et al. Nat Commun, 2024 May 17. PMID 38760342, Free PMC Article
  5. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
32 kDa beta-galactoside-binding lectin lec-3;Galectin;gaLECtin
NP_001022531.1
  • Confirmed by transcript evidence
NP_001022532.1
  • Partially confirmed by transcript evidence
NP_001022533.1
  • Partially confirmed by transcript evidence
NP_001022534.1
  • Product from WormBase gene class lec;
    Confirmed by transcript evidence
NP_001263668.1
  • Confirmed by transcript evidence
NP_496159.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9991160..10000350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276739.3 → NP_001263668.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAG1
    Conserved Domains (1) summary
    cd00070
    Location:198 → 328
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  2. NM_001027360.6 → NP_001022531.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022531.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZI4
    Conserved Domains (1) summary
    cd00070
    Location:158 → 276
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  3. NM_063758.9 → NP_496159.1  32 kDa beta-galactoside-binding lectin lec-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496159.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09581, Q9GNP6
    Conserved Domains (1) summary
    cd00070
    Location:158 → 288
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  4. NM_001027361.4 → NP_001022532.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022532.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4A5
    Conserved Domains (2) summary
    cd00070
    Location:14 → 144
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    cl00071
    Location:162 → 205
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  5. NM_001027362.7 → NP_001022533.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4A4
    Conserved Domains (1) summary
    cd00070
    Location:162 → 303
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

  6. NM_001027363.5 → NP_001022534.1  gaLECtin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022534.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4A3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09581.3

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