U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pat-12 Protein pat-12 [ Caenorhabditis elegans ]

Gene ID: 175227, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
pat-12
Official Full Name
Protein pat-12
Primary source
WormBase:WBGene00003936
Locus tag
CELE_T17H7.4
See related
AllianceGenome:WB:WBGene00003936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Is expressed in hypodermis; neurons; pharynx; rectum; and reproductive system. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See pat-12 in Genome Data Viewer
Location:
chromosome: III
Exon count:
29
Sequence:
Chromosome: III; NC_003281.10 (727207..752426, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein Neighboring gene ncRNA Neighboring gene VPSAGDMMVRF-amide Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Mucin-5AC Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. Hetherington S, et al. Dev Biol, 2011 Feb 15. PMID 21130760
  2. Silencing of essential genes by RNA interference in Haemonchus contortus. Zawadzki JL, et al. Parasitology, 2012 Apr. PMID 22348596
  3. Induction of protective response to polystyrene nanoparticles associated with methylation regulation in Caenorhabditis elegans. Wang S, et al. Chemosphere, 2021 May. PMID 33453486
  4. Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5. Fisk Green R, et al. Mol Genet Genomics, 2004 Jun. PMID 15138888
  5. Predicting aging/longevity-related genes in the nematode Caenorhabditis elegans. Witten TM, et al. Chem Biodivers, 2007 Nov. PMID 18027377

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAT-12 defines a novel component of C. elegans hemidesmosomes, which is required for maintaining their integrity
    Title: PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemidesmosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein pat-12
NP_001359886.1
  • Confirmed by transcript evidence
NP_001367549.1
  • Confirmed by transcript evidence
NP_001367550.1
  • Confirmed by transcript evidence
NP_001367551.1
  • Confirmed by transcript evidence
NP_001367552.1
  • Confirmed by transcript evidence
NP_001367554.1
  • Confirmed by transcript evidence
NP_001367555.1
  • Confirmed by transcript evidence
NP_001368692.1
  • Confirmed by transcript evidence
NP_001379711.1
  • Partially confirmed by transcript evidence
NP_741076.1
  • Confirmed by transcript evidence
NP_741077.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    727207..752426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381698.1 → NP_001367550.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_001381703.2 → NP_001367552.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  3. NM_171067.5 → NP_741076.1  Protein pat-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95QA6

  4. NM_171068.5 → NP_741077.1  Protein pat-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95QA6

  5. NM_001393260.1 → NP_001379711.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    PHA03307
    Location:891 → 1028
    PHA03307; transcriptional regulator ICP4; Provisional

  6. NM_001381699.1 → NP_001367549.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KYY3, H2KYY4, H2KYY5, H2KYY6, H2KYY7, H2KYY8, H2KYY9, H2KYZ0, H2KYZ1, H2KYZ2, Q8MPW4, Q95QA6

  7. NM_001373834.2 → NP_001359886.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  8. NM_001381702.2 → NP_001367555.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  9. NM_001381700.1 → NP_001367551.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  10. NM_001381701.2 → NP_001367554.1  Protein pat-12 [Caenorhabditis elegans]

    Status: REVIEWED

  11. NM_001381705.1 → NP_001368692.1  Protein pat-12, partial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5ATV2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95QA6.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools