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cic-1 Cyclin-C [ Caenorhabditis elegans ]

Gene ID: 175357, updated on 9-Dec-2024

Summary

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Official Symbol
cic-1
Official Full Name
Cyclin-C
Primary source
WormBase:WBGene00000506
Locus tag
CELE_H14E04.5
See related
AllianceGenome:WB:WBGene00000506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in neurons. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cic-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (2394325..2401221, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Winged helix-turn-helix domain-containing protein Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sterol 4-C-methyltransferase strm-1 Neighboring gene 39S ribosomal protein L30, mitochondrial Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metazoan operons accelerate recovery from growth-arrested states. Zaslaver A, et al. Cell, 2011 Jun 10. PMID 21663799, Free PMC Article
  2. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans. Grants JM, et al. Genetics, 2016 Feb. PMID 26715664, Free PMC Article
  3. Identification of genes interacting with rnt-1 through large-scale RNAi screening in Caenorhabditis elegans. Lee K, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979934, Free PMC Article
  4. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
  5. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyclin-C
NP_497548.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2394325..2401221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065147.7 → NP_497548.2  Cyclin-C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497548.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TYP2
    Conserved Domains (2) summary
    cd00043
    Location:64 → 108
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl00050
    Location:162 → 261
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TYP2.2

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