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thoc-5 THO complex subunit 5 [ Caenorhabditis elegans ]

Gene ID: 175735, updated on 2-Nov-2024

Summary

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Official Symbol
thoc-5
Official Full Name
THO complex subunit 5
Primary source
WormBase:WBGene00021311
Locus tag
CELE_Y32H12A.2
See related
AllianceGenome:WB:WBGene00021311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See thoc-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5345931..5349401, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Suppressor of organelle fusion 2 Neighboring gene R3H domain-containing protein Neighboring gene Glutaredoxin domain-containing protein Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Dehydrogenase/reductase SDR family member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans. Morgan KL, et al. Toxicol Sci, 2010 Dec. PMID 20833709, Free PMC Article
  2. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article
  3. Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans. Estevez AO, et al. Neurotoxicology, 2012 Oct. PMID 22560997, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of THO complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
THO complex subunit 5
NP_001254926.1
  • Confirmed by transcript evidence
NP_001254927.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5345931..5349401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267998.4 → NP_001254927.1  THO complex subunit 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C2BR94
    Conserved Domains (1) summary
    pfam09766
    Location:100 → 433
    FimP; Fms-interacting protein

  2. NM_001267997.3 → NP_001254926.1  THO complex subunit 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254926.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0N5
    Conserved Domains (1) summary
    pfam09766
    Location:100 → 431
    FimP; Fms-interacting protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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