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pst-1 Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [ Caenorhabditis elegans ]

Gene ID: 178980, updated on 4-Jan-2025

Summary

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Official Symbol
pst-1
Official Full Name
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Primary source
WormBase:WBGene00004206
Locus tag
CELE_M03F8.2
See related
AllianceGenome:WB:WBGene00004206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport. Located in Golgi cisterna membrane. Is expressed in AMshL; AMshR; pharyngeal gland cell; and seam cell. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pst-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (5943467..5951417)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Neur_chan_LBD domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans. Dejima K, et al. J Biol Chem, 2010 Aug 6. PMID 20529843, Free PMC Article
  2. The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Bhattacharya R, et al. J Cell Sci, 2009 Dec 15. PMID 19920077, Free PMC Article
  3. Most ultraviolet irradiation induced mutations in the nematode Caenorhabditis elegans are chromosomal rearrangements. Stewart HI, et al. Mutat Res, 1991 Jul. PMID 2067542
  4. Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans. Johnsen RC, et al. Genetics, 1991 Nov. PMID 1752418, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pst-1 and pst-2 play different physiological roles in heparan sulfate modification and development
    Title: Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.
  2. pst-1 is required for cell viability and nervous system development.
    Title: The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
NP_001024060.1
  • Confirmed by transcript evidence
NP_001360551.1
  • Confirmed by transcript evidence
NP_001380252.1
  • Confirmed by transcript evidence
NP_741545.2
  • Confirmed by transcript evidence
NP_741546.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5943467..5951417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373028.2 → NP_001360551.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WUZ8
    Conserved Domains (1) summary
    pfam08449
    Location:106 → 376
    UAA; UAA transporter family

  2. NM_171463.5 → NP_741545.2  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741545.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16377, Q59DN2, Q59DN3, Q59DN4, Q8MXJ9
    Conserved Domains (2) summary
    pfam08449
    Location:106 → 408
    UAA; UAA transporter family
    cl23754
    Location:297 → 408
    EamA; EamA-like transporter family

  3. NM_171464.6 → NP_741546.3  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741546.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXJ9
    Conserved Domains (2) summary
    pfam08449
    Location:121 → 423
    UAA; UAA transporter family
    cl23754
    Location:312 → 423
    EamA; EamA-like transporter family

  4. NM_001028889.4 → NP_001024060.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024060.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MXJ9
    Conserved Domains (1) summary
    pfam08449
    Location:121 → 391
    UAA; UAA transporter family

  5. NM_001392522.1 → NP_001380252.1  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WVL2
    Conserved Domains (1) summary
    pfam08449
    Location:1 → 106
    UAA; UAA transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MXJ9.4

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