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DOK1 docking protein 1 [ Homo sapiens (human) ]

Gene ID: 1796, updated on 27-Nov-2024

Summary

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Official Symbol
DOK1provided by HGNC
Official Full Name
docking protein 1provided by HGNC
Primary source
HGNC:HGNC:2990
See related
Ensembl:ENSG00000115325 MIM:602919; AllianceGenome:HGNC:2990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pp62; P62DOK
Summary
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

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See DOK1 in Genome Data Viewer
Location:
2p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74549105..74557551)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74557671..74566117)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74776232..74784678)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74756279-74757161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16075 Neighboring gene DEAQ-box RNA dependent ATPase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74763605-74764106 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11669 Neighboring gene Sharpr-MPRA regulatory regions 4995 and 13004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74781947-74782464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16079 Neighboring gene meiosis 1 associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16081 Neighboring gene TOR1B pseudogene 1 Neighboring gene TVP23B pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Lee S, et al. Proc Natl Acad Sci U S A, 2004 Dec 14. PMID 15574499, Free PMC Article
  2. Epstein-Barr virus down-regulates tumor suppressor DOK1 expression. Siouda M, et al. PLoS Pathog, 2014 May. PMID 24809689, Free PMC Article
  3. Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. Saulnier A, et al. Int J Cancer, 2012 Jun 1. PMID 21796618, Free PMC Article
  4. Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation. Janas JA, et al. Mol Cell Biol, 2011 Jul. PMID 21536658, Free PMC Article
  5. Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation. Kobayashi R, et al. FEBS Lett, 2009 Jul 21. PMID 19481542

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.
    Title: Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.
  2. Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.
    Title: Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.
  3. Analysis of the DOK1 gene in breast cancer.
    Title: Analysis of the DOK1 gene in breast cancer.
  4. Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.
    Title: Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.
  5. Decreased DOK1/2 expressions associated with their promoter hypermethylations predict adverse prognosis in AML.
    Title: Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.
  6. Taken together, these results indicate that ATRA-enhanced expression of DOK1 activates PPARgamma leading to inhibition of cell proliferation and enhancement of cell apoptosis in MCF-7 cell.
    Title: DOK1/PPARgamma pathway mediates anti-tumor ability of all-trans retinoic acid in breast cancer MCF-7 cells.
  7. DOK1 was identified as a prognostic factor for non-metastatic CRC, and, via its drugability by PPARgamma-agonist, may constitute a potential target for future cancer treatments.
    Title: Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.
  8. DOK3 expression was not altered much in HTLV-1-infected T cells.
    Title: Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
  9. Results indicate that hypermethylation of tumor suppressor protein RASSF1A and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.
    Title: RASSF1A and DOK1 Promoter Methylation Levels in Hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients.
  10. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (downstream of tyrosine kinase 1) (Dok1) interaction.
    Title: An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with docking protein 1 (DOK1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117395, MGC138860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
docking protein 1
Names
Downstream of tyrosine kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050617.1 RefSeqGene

    Range
    11516..14347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197260.2 → NP_001184189.1  docking protein 1 isoform b

    See identical proteins and their annotated locations for NP_001184189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as 2) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AF035299, BQ575925, DA382785
    Consensus CDS
    CCDS56125.1
    UniProtKB/Swiss-Prot
    Q99704
    Related
    ENSP00000387016.1, ENST00000409429.5
    Conserved Domains (1) summary
    cd01203
    Location:12 → 114
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

  2. NM_001318866.2 → NP_001305795.1  docking protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AK055944, AK314678, BQ575925
    Consensus CDS
    CCDS56125.1
    UniProtKB/TrEMBL
    B3KP83
    Conserved Domains (1) summary
    cd01203
    Location:12 → 114
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

  3. NM_001318867.2 → NP_001305796.1  docking protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AK055944, AK296154, BQ575925
    UniProtKB/TrEMBL
    B3KP83, B4DJN1, Q53GP8
    Conserved Domains (3) summary
    cd01203
    Location:140 → 242
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    pfam00169
    Location:8 → 105
    PH; PH domain
    cl17171
    Location:11 → 108
    PH-like; Pleckstrin homology-like domain

  4. NM_001318868.2 → NP_001305797.1  docking protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BC111055, BQ575925
    Consensus CDS
    CCDS82474.1
    UniProtKB/Swiss-Prot
    Q99704
    UniProtKB/TrEMBL
    B3KP83, Q2TA81
    Related
    ENSP00000344330.6, ENST00000340004.6
    Conserved Domains (1) summary
    cl17171
    Location:6 → 119
    PH-like; Pleckstrin homology-like domain

  5. NM_001318869.2 → NP_001305798.1  docking protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BC114497, BQ575925
    UniProtKB/TrEMBL
    Q14CB2, Q2TA81
    Conserved Domains (1) summary
    cl17171
    Location:1 → 39
    PH-like; Pleckstrin homology-like domain

  6. NM_001381.5 → NP_001372.1  docking protein 1 isoform a

    See identical proteins and their annotated locations for NP_001372.1

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BQ575925
    Consensus CDS
    CCDS1954.1
    UniProtKB/Swiss-Prot
    O43204, Q53TY2, Q99704, Q9UHG6
    UniProtKB/TrEMBL
    B3KP83, Q53GP8
    Related
    ENSP00000233668.5, ENST00000233668.10
    Conserved Domains (2) summary
    cd01203
    Location:151 → 253
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:6 → 119
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    74549105..74557551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    74557671..74566117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99704.1 GenPept UniProtKB/Swiss-Prot:Q99704

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